Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Ekkehard Leberer"'
Autor:
Lucy Phillips, Shiguang Liu, Fang Wang, Li Yang, Oxana Ibraghimov-Beskrovnaya, Deidre Mackenna, Jifan Guo, Suxia Wang, Wenping Song, Jie Ding, Ekkehard Leberer, Cynthia Pryce, Ethan Y Xu, Qun He, Yanqin Zhang, Joseph Boulanger
Publikováno v:
Human Gene Therapy. 30:865-881
Alport syndrome is a genetic disease caused by mutations in type IV collagen and is characterized by progressive kidney disease. The Col4α3−/− mouse model recapitulates the main features of human A...
Autor:
Ragna Guldsmed Diedrichsen, Ekkehard Leberer, Melissa Besenius, Mie Kristensen, Ulrich Werner, Stine Harloff-Helleberg, Hanne Mørck Nielsen
Publikováno v:
Diedrichsen, R G, Harloff-Helleberg, S, Werner, U, Besenius, M, Leberer, E, Kristensen, M & Nielsen, H M 2021, ' Revealing the importance of carrier-cargo association in delivery of insulin and lipidated insulin ', Journal of Controlled Release, vol. 338, pp. 8-21 . https://doi.org/10.1016/j.jconrel.2021.07.030
Delivery of therapeutic peptides upon oral administration is highly desired and investigations report that the cell-penetrating peptide (CPP) penetratin and its analogues shuffle and penetramax show potential as carriers to enhance insulin delivery.
Publikováno v:
Nachrichten aus der Chemie. 57:1130-1133
Autor:
Lyne Johnson, Sophia Ushinsky, Klaus Schröppel, Doreen Harcus, David Y. Thomas, Ekkehard Leberer, Daniel Dignard
Publikováno v:
Molecular Microbiology. 42:673-687
The pathogenic fungus Candida albicans is capable of responding to a wide variety of environmental cues with a morphological transition from a budding yeast to a polarized filamentous form. We demonstrate that the Ras homologue of C. albicans, CaRas1
Autor:
Sophia Ushinsky, Malcolm Whiteway, Sonja Michel, Bert Klebl, Ekkehard Leberer, David Y. Thomas, Joachim Morschhäuser
Publikováno v:
Molecular Microbiology. 46:269-280
The yeast Candida albicans is the most important fungal pathogen of humans and a model organism for studying fungal virulence. Sequencing of the C. albicans genome will soon be completed, allowing systematic approaches to analyse gene function. Howev
Publikováno v:
Eukaryotic Cell. 1:213-228
The pathogenic yeast Candida albicans can undergo a dramatic change in morphology from round yeast cells to long filamentous cells called hyphae. We have cloned the CaMYO5 gene encoding the only myosin I in C . albicans . A strain with a deletion of
Autor:
Anne Marcil, Sophia Ushinsky, Joachim Morchhauser, Ekkehard Leberer, Daniel Dignard, Doreen Harcus, David Y. Thomas, Josée Ash, Malcolm Whiteway
Publikováno v:
Eukaryotic Cell. 1:95-104
Cdc42p is a member of the RAS superfamily of GTPases and plays an essential role in polarized growth in many eukaryotic cells. We cloned the Candida albicans CaCDC42 by functional complementation in Saccharomyces cerevisiae and analyzed its function
Autor:
Andy Ng, Richard Gingras, David Y. Thomas, Feng Ni, Zhigang Chen, Ping Xu, Jianxing Song, Ekkehard Leberer
Publikováno v:
Journal of Biological Chemistry. 276:41205-41212
The transmission of the mating signal of the budding yeast Saccharomyces cerevisiae requires Ste20p, a member of the serine/threonine protein kinases of the Ste20p/PAK family, to link the Gβ subunit of the heterotrimeric G protein to the mitogen-act
Autor:
Martin Röllinghoff, Christian Bogdan, Ekkehard Leberer, Martin Herrmann, Klaus Schröppel, Michael Kryk
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
Macrophages (Mphi) are important for the defence against experimental disseminated candidiasis. Nitric oxide (NO) generated by the inducible isoform of NO-synthase (iNOS or NOS2) is thought to contribute to candidacidal effector functions by activate
Autor:
Karen L. Clark, Daniel Dignard, Ekkehard Leberer, Malcolm Whiteway, Martine Raymond, Sandra Weber, Anne-Marie Alarco, David Y. Thomas
Publikováno v:
Yeast. 16:531-538
In a screen for Candida albicans genes capable of supressing a ste20Δ mutation in Saccharomyces cerevisiae, a homologue of the exportin-encoding gene CRM1 was isolated. The CaCRM1 gene codes for a protein of 1079 amino acids with a predicted molecul