Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Ekkehard Baader"'
1
Beneficial effects of inhibitors of prolyl 4-hydroxylase in CCl4-induced fibrosis of the liver in rats
Autor: M. Bickel, D.G. Brocks, G.H. Vogel, Ekkehard Baader, K. Engelbart, V. Günzler, H.L. Schmidts
Publikováno v: Journal of Hepatology. 13:S26-S34
S 0885 and HOE 077 inhibit CCl 4 -induced liver fibrosis in rats, as shown by significantly reduced hydroxyproline content of the liver and improved liver histology. Mortality of drug-treated animals is significantly diminished. Serum collagen parame
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff633f656d72497181d5cf1dbc06a66
https://doi.org/10.1016/0168-8278(91)90005-v
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2
Pharmacokinetics and metabolism of HOE 077
Autor: Gert Ulrich Kürzel, Manfred Volz, Ekkehard Baader, Hans-Martin Kellner, Hans Georg Eckert
Publikováno v: Journal of Hepatology. 13:S48-S62
The studies were performed in healthy male rats and in one male dog after oral and intravenous administration of [2-carbamoyl-14C]HOE 077. HOE 077 wa rapidly and completely absorbed after oral administration. In blood, tmax was at about 0.5 h and cma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85efd62af3df1279c1a984a02d2b7ebc
https://doi.org/10.1016/0168-8278(91)90008-y
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3
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids
Autor: W. Schubert, Bartmann W, Kurt Kesseler, H. Jendralla, Granzer Ernold, Ekkehard Baader, von Kerekjarto B, Beck G, R. Krause, A. Bergmann
Publikováno v: Journal of Medicinal Chemistry. 33:61-70
A series of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)- enoates (-heptanoates) 1 and 2 have been prepared and tested for inhibiti 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The most potent compounds exceeded mevinolin's activity in v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21e56d77f592e3247ac6e05d7d9b6b5
https://doi.org/10.1021/jm00163a011
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4
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids
Autor: A. Bergmann, R. Krause, B. Von Kerekjarto, Ekkehard Baader, Schacht U, G. Beck, Granzer Ernold, H. Jendralla, W. Bartmann, Kurt Kesseler
Publikováno v: Journal of medicinal chemistry. 34(10)
A group of 43 optically active sodium carboxylates (11a-qq and the corresponding lactones 4 were prepared from respective phenols 8 according to Schemes I-III. Phenols 8 were synthesized from commercially available compounds according to Schemes IV-I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86db0cabf9beb006a2268c993bd3633b
https://pubmed.ncbi.nlm.nih.gov/1656041
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9
Viriplanin A, a new anthracycline antibiotic of the nogalamycin group. I. Isolation, characterization, degradation reactions and biological properties
Autor: Axel Zeeck, Wolfgang Gau, Theo Schröder, Klaus Frobel, Wolfgang Karl, Christian Wünsche, Ekkehard Baader, Klaus Dr Bauer, Detlef Wendisch, Jürgen Kurz, Klaus Hütter
Publikováno v: The Journal of antibiotics. 39(9)
Viriplanin A, a new anthracycline antibiotic produced by Ampullariella regularis strain SE 47, was isolated from a raw product that demonstrated activity against Herpes simplex viruses. Based on spectroscopic data, the structure of the aglycone, viri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfe91f8236cfc2a7f3faabfd0088af9
https://pubmed.ncbi.nlm.nih.gov/3023268
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