Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ekin Guney"'
Autor:
Felipe Andreiuolo, Christina K. Ferrone, Sharika Rajan, Arie Perry, Ekin Guney, Elaine Cham, Caterina Giannini, Angus Toland, Nicholas Willard, Andrea Silveira de Souza, Karen Dazelle, Hye-Jung Chung, Omkar Singh, Kyle Conway, Nicholas Coley, Christopher Dampier, Zied Abdullaev, Drew Pratt, Patrick J. Cimino, Martha Quezado, Kenneth Aldape
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Central nervous system (CNS) embryonal tumors are a heterogeneous group of high-grade malignancies, and the increasing clinical use of methylation profiling and next-generation sequencing has led to the identification of molecularly distinct
Externí odkaz:
https://doaj.org/article/4fff28e808b7469b8bce2849fa21e918
Autor:
Ekin Guney, Kwun Wah Wen, Roberto Ruiz-Cordero, Linda Ferrell, Ryan M. Gill, Dennis O'Malley, Kirk D. Jones, Robert Ohgami
Publikováno v:
Human Pathology: Case Reports, Vol 24, Iss , Pp 200509- (2021)
Cystic lesions of the spleen are rare and challenging to diagnose, often generating a broad differential diagnosis. However, a comprehensive approach which includes molecular studies, may result in an accurate diagnosis and further provide insight in
Externí odkaz:
https://doaj.org/article/97ac155f4ec24abebf3f63a660537696
Autor:
Ekin Guney, Calixto-Hope G. Lucas, Kunwar Singh, Melike Pekmezci, Sebastian Fernandez-Pol, Kanish Mirchia, Angus Toland, Hannes Vogel, Serguei I Bannykh, Kristian T. Schafernak, Sanda Alexandrescu, Bret C. Mobley, Suzanne Z. Powell, Christian Davidson, Janna Neltner, Daniel R Boué, Eyas M Hattab, Sean P. Ferris, Robert S. Ohgami, James Louis Rubenstein, Andrew Wesley Bollen, Tarik Tihan, Arie Perry, David A. Solomon, Kwun Wah Wen
Publikováno v:
Blood Advances.
Autor:
Ethan A Winkler, Joseph Garcia, Cynthia Tsang, Jeffrey Nelson, Charles McCulloch, Shantel Weinsheimer, Christine K Fox, Heather Fullerton, Nerissa Ko, Hua Su, Tomasz Nowakowski, Daniel L Cooke, Steven Hetts, Ekin Guney, MELIKE PEKMEZCI, Tarik Tihan, Michael Lawton, Adib Abla, Nalin Gupta, Helen Kim
Publikováno v:
Stroke. 54
Introduction: Sporadic brain arteriovenous malformations (bAVMs) are a potentially treatable cause of stroke disproportionately affecting young people. Non-inherited somatic activating mutations in KRAS have been reported in ~50% of bAVM specimens pr
Autor:
Ekin Guney, Ana Paula Arruda, Günes Parlakgul, Erika Cagampan, Nina Min, Grace Yankun Lee, Lily Greene, Eva Tsaousidou, Karen Inouye, Myoung Sook Han, Roger J. Davis, Gökhan S. Hotamisligil
Publikováno v:
Science Signaling. 14
Inhibiting IP 3 Rs in adipocytes may prevent the development of obesity-induced metabolic complications.
Autor:
Ekin, Guney, Ana Paula, Arruda, Günes, Parlakgul, Erika, Cagampan, Nina, Min, Grace Yankun, Lee, Lily, Greene, Eva, Tsaousidou, Karen, Inouye, Myoung Sook, Han, Roger J, Davis, Gökhan S, Hotamisligil
Publikováno v:
Sci Signal
Chronic metabolic inflammation is a key feature of obesity, insulin resistance, and diabetes. Here, we showed that altered regulation of the Ca(2+) channel inositol trisphosphate receptor (IP3R) was an adipocyte-intrinsic event involved in the emerge
Autor:
Dennis P. O'Malley, Ryan M. Gill, Kirk D. Jones, Roberto Ruiz-Cordero, Linda D. Ferrell, Robert S. Ohgami, Ekin Guney, Kwun Wah Wen
Publikováno v:
Human Pathology: Case Reports, Vol 24, Iss, Pp 200509-(2021)
Cystic lesions of the spleen are rare and challenging to diagnose, often generating a broad differential diagnosis. However, a comprehensive approach which includes molecular studies, may result in an accurate diagnosis and further provide insight in
Autor:
Eva Tsaousidou, Jędrzej Chrzanowski, Pascal Drané, Grace Y. Lee, Nadine Bahour, Zeqiu Branden Wang, Shijun Deng, Zhe Cao, Kaimeng Huang, Yizhou He, Mateusz Kaminski, Dominika Michalek, Ekin Güney, Kalindi Parmar, Wojciech Fendler, Dipanjan Chowdhury, Gökhan S. Hotamışlıgil
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114337- (2024)
Summary: It is unclear whether metabolic health corresponds to reduced oncogenesis or vice versa. We study Tudor-interacting repair regulator (TIRR), an inhibitor of p53 binding protein 1 (53BP1)-mediated p53 activation, and the physiological consequ
Externí odkaz:
https://doaj.org/article/c830c19e952a4a9ebd6b580b85dca154
Autor:
Xu Cs, Ana Paula Arruda, Cagampan E, Ekin Guney, Gökhan S. Hotamisligil, Gunes Parlakgul, Pang S, Yvonne C. Lee, Hess Hf
Cells display complex intracellular organization through compartmentalization of metabolic processes into organelles, yet neither the resolution of these structures in the native tissue context nor its functional consequences are well understood. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::304eff730c4e34950b0c4f3f39a9d8d3
https://doi.org/10.1101/2020.11.18.387803
https://doi.org/10.1101/2020.11.18.387803
Autor:
Ana Paula Arruda, Benedicte Mengel Pers, Ekin Guney, Erika Cagampan, Gökhan S. Hotamisligil, Ted Goh, Gunes Parlakgul, Grace Y. Lee, Renata L.S. Goncalves
Publikováno v:
eLife, Vol 6 (2017)
Arruda, A P, Pers, B M, Parlakgul, G, Guney, E, Goh, T, Cagampan, E, Lee, G Y, Goncalves, R L & Hotamisligil, G S 2017, ' Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity ', eLife, vol. 6, e29968 . https://doi.org/10.7554/eLife.29968
Arruda, A P, Pers, B M, Parlakgul, G, Guney, E, Goh, T, Cagampan, E, Lee, G Y, Goncalves, R L & Hotamisligil, G S 2017, ' Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity ', eLife, vol. 6, e29968 . https://doi.org/10.7554/eLife.29968
Defective Ca2+ handling is a key mechanism underlying hepatic endoplasmic reticulum (ER) dysfunction in obesity. ER Ca2+ level is in part monitored by the store-operated Ca2+ entry (SOCE) system, an adaptive mechanism that senses ER luminal Ca2+ conc