Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ekaterina Zezina"'
Autor:
Lingzi Li, Janina Freitag, Christian Asbrand, Bogdan Munteanu, Bei-Tzu Wang, Ekaterina Zezina, Michel Didier, Gilbert Thill, Corinne Rocher, Matthias Herrmann, Nadine Biesemann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-20 (2022)
Abstract Rheumatoid arthritis (RA) is characterized by joint infiltration of immune cells and synovial inflammation which leads to progressive disability. Current treatments improve the disease outcome, but the unmet medical need is still high. New d
Externí odkaz:
https://doaj.org/article/5ab8fa376cd44e9c93d89d8361b62c7d
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract TNF is a central cytokine in the pathogenesis of rheumatoid arthritis (RA). Elevated level of TNF causes local inflammation that affects immune cells and fibroblast-like synoviocytes (FLS). Nowadays, only 20–30% of patients experience remi
Externí odkaz:
https://doaj.org/article/695dcc322f0344b397d04593c01b217c
Autor:
Ryan G. Snodgrass, Ekaterina Zezina, Dmitry Namgaladze, Sahil Gupta, Carlo Angioni, Gerd Geisslinger, Dieter Lütjohann, Bernhard Brüne
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interle
Externí odkaz:
https://doaj.org/article/d7a10fff9ad64af8bd354fb6ea7e9273
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
TNF is a central cytokine in the pathogenesis of rheumatoid arthritis (RA). Elevated level of TNF causes local inflammation that affects immune cells and fibroblast-like synoviocytes (FLS). Nowadays, only 20–30% of patients experience remission aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f64ed06b88d8684ea6865420a08d1d4
https://doaj.org/article/695dcc322f0344b397d04593c01b217c
https://doaj.org/article/695dcc322f0344b397d04593c01b217c
Publikováno v:
WIREs Systems Biology and Medicine. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbcbc1695aa277bdd1147e3f08c05ebf
https://doi.org/10.1002/wsbm.1498
https://doi.org/10.1002/wsbm.1498
Publikováno v:
WIREs Systems Biology and Medicine. 12
Knowledge about metabolism of immune cells increased almost exponentially during the last two decades and thereby created the new area immunometabolism. Increased glucose uptake and glycolysis were identified as one of the major drivers in immune cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b437c12ea06383a3f1768d79637db0d5
https://doi.org/10.1002/wsbm.1483
https://doi.org/10.1002/wsbm.1483
Autor:
Dominique Thomas, Andreas Weigert, Ekaterina Zezina, Dagmar Meyer zu Heringdorf, Dominik C. Fuhrmann, Bernhard Brüne, Isabel Faria, Heinfried H. Radeke, Andreas von Knethen, Dmitry Namgaladze, Anton Petcherski
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1864(9)
Sphingosine kinases (SPHK) generate the sphingolipid sphingosine-1-phosphate, which, among other functions, is a potent regulator of inflammation. While SPHK1 produces S1P to promote inflammatory signaling, the role of SPHK2 is unclear due to diverge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471736eb341b563d20a5fec35586e107
https://pubmed.ncbi.nlm.nih.gov/31128248
https://pubmed.ncbi.nlm.nih.gov/31128248
Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses
Autor:
Dmitry Namgaladze, Ekaterina Zezina, Yannick Schreiber, Gerd Geisslinger, Dagmar Meyer zu Heringdorf, Ingrid Fleming, Christoph Schürmann, Sven Zukunft, Ryan G. Snodgrass, Bernhard Brüne, Ralf P. Brandes
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1863(4)
Macrophages in adipose tissue contribute to inflammation and the development of insulin resistance in obesity. Exposure of macrophages to saturated fatty acids alters cell metabolism and activates pro-inflammatory signaling. How fatty acids influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6e213a6ce2db709dced66e8292c453
https://pubmed.ncbi.nlm.nih.gov/29360568
https://pubmed.ncbi.nlm.nih.gov/29360568
Autor:
Bernhard Brüne, Dmitry Namgaladze, Ekaterina Zezina, Marcel Boß, Nathalie Dehne, Ingrid Fleming, Andreas Weigert, Ryan G. Snodgrass
Publikováno v:
The Journal of biological chemistry, vol 291, iss 1
Pro-inflammatory cytokines secreted by adipose tissue macrophages (ATMs) contribute to chronic low-grade inflammation and obesity-induced insulin resistance. Recent studies have shown that adipose tissue hypoxia promotes an inflammatory phenotype in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39477e131b72679cd6d89cf7024b9333
https://europepmc.org/articles/PMC4697177/
https://europepmc.org/articles/PMC4697177/
