Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ekaterina V, Bobkova"'
Autor:
Manfred Kraus, Jannik N. Andersen, Peter Blume-Jensen, Nancy Kohl, Victoria Richon, Giulio Draetta, Martin L. Scott, Roderick T. Bronson, Shailaja Kasibhatla, Ekaterina V. Bobkova, Alan Northrup, Thomas F. Vogt, Myung K. Shin, Melissa Hurd, Paula Andrade, Erica Leccese, Minilik Angagaw, Nirah H. Shomer, Diana Gargano, Alessandra Di Bacco, Yusuf Erkul, Erin O'Hare, Kumiko Nagashima, Kun Hu, Yamicia Connor, Brian Dolinski, Kaiko Kunii, Heike Keilhack, Katharine Ellwood-Yen
Supplementary Figures 1-4 from PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828919a62a5a02040e157eb5ac219fb4
https://doi.org/10.1158/0008-5472.22390089
https://doi.org/10.1158/0008-5472.22390089
Autor:
Cloud P Paweletz, Jannik N Andersen, Roy Pollock, Kumiko Nagashima, Mansuo L Hayashi, Shangshuan U Yu, Hongbo Guo, Ekaterina V Bobkova, Zangwei Xu, Alan Northrup, Peter Blume-Jensen, Ronald C Hendrickson, An Chi
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26459 (2011)
Pharmacodynamic (PD) biomarkers are an increasingly valuable tool for decision-making and prioritization of lead compounds during preclinical and clinical studies as they link drug-target inhibition in cells with biological activity. They are of part
Externí odkaz:
https://doaj.org/article/ecc88f9d2bf143f09228d27bcd3a4329
Autor:
Thomas D.Y. Chung, Sharon A. Colayco, Baozong Li, Li Du, Jianghai Wang, Yi-Jia Li, Ramir Vega, Daniela B. Divlianska, Grace Aldana-Masangkay, Ekaterina V. Bobkova, Terry D. Lee, Yunan Miao, Marwan Fakih, Eduard Sergienko, Yuan Chen, S. Xiaohu Ouyang, Eric R. Samuels
Publikováno v:
Cell chemical biology. 26(2)
Summary Ubiquitin-like (Ubl) post-translational modifications are potential targets for therapeutics. However, the only known mechanism for inhibiting a Ubl-activating enzyme is through targeting its ATP-binding site. Here we identify an allosteric i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6262e81209415b5aea89a530f02dd0d
https://pubmed.ncbi.nlm.nih.gov/30794786
https://pubmed.ncbi.nlm.nih.gov/30794786
Autor:
Xochella Chan, Eduard Sergienko, David A Critton, Ekaterina V. Bobkova, Nicholas D. P. Cosford, Li Yang, Rebecca Page, Paul J. Lombroso, Brock Brown, Shyama Sidique, Justin Rascon, Stefan Vasile, Ying Su, Thomas D.Y. Chung, Russell Dahl, Tomas Mustelin, Hongbin Yuan, Sharon Colayco, Wallace Liu, Lutz Tautz, Jian Xu
Publikováno v:
ACS Chemical Biology. 7:367-377
The hematopoietic protein tyrosine phosphatase (HePTP) is implicated in the development of blood cancers through its ability to negatively regulate the mitogen-activated protein kinases (MAPKs) ERK1/2 and p38. Small-molecule modulators of HePTP activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a0a8233e260ab3586098511742b7ce
https://doi.org/10.1021/cb2004274
https://doi.org/10.1021/cb2004274
Autor:
Youyuan Xu, Cloud P. Paweletz, Maciej Wiznerowicz, Victoria M. Richon, Sanjeev Munshi, Brian Dolinski, Kumiko Nagashima, Anke Klippel, Sujal V. Deshmukh, Peter Blume-Jensen, Bo-Sheng Pan, Jannik N. Andersen, Alan B. Northrup, Timothy Allison, Alexander A. Szewczak, Zangwei Xu, Manfred Kraus, Heike Keilhack, Sriram Sathyanarayanan, Youwei Yan, Albert H. Y. Chen, Uwe Mueller, Lixia Li, An Chi, Thi D.T. Nguyen, Ekaterina V. Bobkova, Roy M. Pollock, Bart Lutterbach, Stuart D. Shumway
Publikováno v:
Journal of Biological Chemistry. 286:6433-6448
Phosphoinositide-dependent kinase 1 (PDK1) is a critical activator of multiple prosurvival and oncogenic protein kinases and has garnered considerable interest as an oncology drug target. Despite progress characterizing PDK1 as a therapeutic target,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d48755b91bbb7ad516b9224524427fa0
https://doi.org/10.1074/jbc.m110.156463
https://doi.org/10.1074/jbc.m110.156463
Autor:
Ekaterina V. Bobkova, Wallace Liu, Lutz Tautz, Xochella Chan, David A Critton, Stefan Vasile, Rebecca Page, Tomas Mustelin, Sharon Colayco, Thomas D.Y. Chung, Carlton Gasior, Ying Su, Justin Rascon, Russell Dahl, Eduard Sergienko
Publikováno v:
ACS Medicinal Chemistry Letters. 2:113-118
Protein tyrosine phosphatases (PTPs) have only recently become the focus of attention in the search for novel drug targets despite the fact that they play vital roles in numerous cellular processes and are implicated in many human diseases. The hemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd638a68deb48d70a6fa99790e71f0d
https://doi.org/10.1021/ml100103p
https://doi.org/10.1021/ml100103p
Autor:
Alan B. Northrup, Yan-Ling Zhang, Zangwei Xu, Michael Weber, Ekaterina V. Bobkova, Priya Kunapuli, Peter Blume-Jensen, Ilona Kariv, Jannik N. Andersen, Joon Jung
Publikováno v:
Journal of Biological Chemistry. 285:18838-18846
The phosphoinositide 3-kinase/AKT signaling pathway plays a key role in cancer cell growth, survival, and angiogenesis. Phosphoinositide-dependent protein kinase-1 (PDK1) acts at a focal point in this pathway immediately downstream of phosphoinositid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8015bd269236cb653d97a02c499579d3
https://doi.org/10.1074/jbc.m109.089946
https://doi.org/10.1074/jbc.m109.089946
Autor:
Michael Weber, Joon Jung, Dongyu Sun, Alan B. Northrup, Ilona Kariv, Zangwei Xu, Thomas S. Rush, Ekaterina V. Bobkova
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 13:16-26
A dynamic, focused screening strategy that utilized a limited but diversified set of target-specific compounds was explored as an efficient means for the identification of inhibitors of the protein kinase PDK1. Approximately 21,500 compounds, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da68acd8fb4546d1f86086d9e29b205
https://doi.org/10.2174/138620710790218186
https://doi.org/10.2174/138620710790218186
Autor:
Ilona Kariv, Alan B. Northrup, Dongyu Sun, Thomas S. Rush, Kumiko Nagashima, Ekaterina V. Bobkova, Zangwei Xu, Jannik N. Andersen
Publikováno v:
SLAS Discovery. 14:1257-1262
The PI3K/Akt signaling pathway plays a key role in cancer cell growth, survival, and tumor angiogenesis. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a Ser/Thr protein kinase, which catalyzes the phosphorylation of a conserved residue in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c64b6ee859c214267787fe54e109207
https://doi.org/10.1177/1087057109349356
https://doi.org/10.1177/1087057109349356
Autor:
Tavner Delcamp, Hariharan Venkatesan, Jennifer M. Miller, Liu Tang, Keysha Onheiber, Brooke Rhead, Alejandro Santillan, Wolin Ronald L, Leslie A. Gomez, Ekaterina V. Bobkova, Emily M. Stocking, Maithri M. K. Jayasekera, Karen Joy Shaw, John M. Keith, Shaoming Huang
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:131-136
Bacterial elongation factor Tu (EF-Tu) and EF-Ts are interacting proteins involved in polypeptide chain elongation in protein biosynthesis. A novel scintillation proximity assay for the detection of inhibitors of EF-Tu and EF-Ts, as well as the inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb99116a2e019b5ee2602c6e47f40a0
https://doi.org/10.1128/aac.49.1.131-136.2005
https://doi.org/10.1128/aac.49.1.131-136.2005