Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Ekaterina Pavlova"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1354 (2024)
Studying the initial molecular mechanisms of the pathogenesis of Parkinson’s disease (PD), primarily in the nigrostriatal dopaminergic system, is one of the priorities in neurology. Of particular interest is elucidating these mechanisms in the prec
Externí odkaz:
https://doaj.org/article/7ce6325d5c9f40ecb758d77648c5c746
Publikováno v:
Genes, Vol 14, Iss 12, p 2202 (2023)
Studying the molecular mechanisms of the pathogenesis of Parkinson’s disease (PD) is critical to improve PD treatment. We used OpenArray technology to assess gene expression in the substantia nigra (SN) cells of mice in a 1-methyl-4-phenyl-1,2,3,6-
Externí odkaz:
https://doaj.org/article/84409c9c44ed430bbcb7f322afde47e3
Autor:
Dmitry Troshev, Alyona Bannikova, Victor Blokhin, Ekaterina Pavlova, Anna Kolacheva, Michael Ugrumov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16245 (2023)
The mammalian striatum is known to contain non-dopaminergic neurons that express dopamine (DA)-synthesizing enzymes and produce DA, responsible for the regulation of motor function. This study assessed the expression of DA-synthesizing enzymes in str
Externí odkaz:
https://doaj.org/article/2eb4a29641744bf2afbd615fbccc1e0a
Publikováno v:
Folia Medica, Vol 64, Iss 1, Pp 41-48 (2022)
Introduction: The testis is an immune privileged organ that provides a specific environment for germ cell development. Various factors responsible for inflammatory changes can lead to deterioration of the immune tolerant model found in the testis. As
Externí odkaz:
https://doaj.org/article/67fd6c7071a148c483b2129c00b7f7a2
Autor:
Alexander Kim, Ekaterina Pavlova, Anna Kolacheva, Vsevolod Bogdanov, Liliya Dilmukhametova, Viktor Blokhin, Lev Valuev, Ivan Valuev, Marina Gorshkova, Michael Ugrumov
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 150, Iss , Pp 112944- (2022)
The fight against neurodegenerative diseases, including Parkinson’s disease (PD), is a global challenge of this century. The effectiveness of current PD therapy is limited, since it is diagnosed many years after the onset, following the death of mo
Externí odkaz:
https://doaj.org/article/344fe14f25b64f3cb8d7c58e2f5578ee
Autor:
Emilia Petrova, Yordanka Gluhcheva, Ekaterina Pavlova, Ivelin Vladov, Peter Dorkov, Martin Schaier, Irena Pashkunova-Martic, Thomas H. Helbich, Bernhard Keppler, Juliana Ivanova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2871 (2023)
Lead (Pb) is a highly toxic heavy metal that has deleterious effects on the central nervous system. This study aimed to investigate the effects of salinomycin (Sal) and deferiprone (DFP) on brain morphology and on the content of some essential elemen
Externí odkaz:
https://doaj.org/article/3a6f03424b664cb19822d9949daeb595
Autor:
Anna Kolacheva, Ekaterina Pavlova, Alyona Bannikova, Vsevolod Bogdanov, Dmitry Troshev, Michael Ugrumov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 3027 (2023)
Given the limited access to clinical material for studying the pathogenesis of Parkinson’s disease (PD), these studies should be carried out on experimental models. We have recently developed a subchronic model of the progressive development of PD
Externí odkaz:
https://doaj.org/article/982eef65065f40f899ea81e3ecaa730f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 683 (2022)
The fight against neurodegenerative diseases, including Parkinson’s disease (PD), is among the global challenges of the 21st century. The low efficiency of therapy is due to the late diagnosis and treatment of PD, which take place when there is alr
Externí odkaz:
https://doaj.org/article/55fe3efa4931427f8d6c0b3a9fdb754e
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14682 (2022)
We have recently shown that the periventricular nucleus (PeVN) of adult rats is a “mixed dopaminergic (DAergic) center” containing three thousand neurons: DAergic neurons and those expressing one of the dopamine (DA)-synthesizing enzymes. This st
Externí odkaz:
https://doaj.org/article/69aeaa8704f0429e804381f00269b5ac
Publikováno v:
Brain Sciences, Vol 12, Iss 6, p 779 (2022)
The progressive degradation of the nigrostriatal system leads to the development of Parkinson’s disease (PD). The synthesis of dopamine, the neurotransmitter of the nigrostriatal system, depends on the rate-limiting enzyme, tyrosine hydroxylase (TH
Externí odkaz:
https://doaj.org/article/a08b8522d86047f6a7491a448bfb9761