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pro vyhledávání: '"Ekaterina N. Domanina"'
Autor:
Tatyana V. Volkova, Ekaterina N. Domanina, Mikhail V. Chislov, Irina V. Terekhova, Alexey N. Proshin
Publikováno v:
Journal of Thermal Analysis and Calorimetry. 140:2305-2315
The derivative of 1,2,4-thiadiazole (TDZ) can be considered as a perspective agent for the Alzheimer’s disease prevention. Due to a highly lipophilic character, the compound reveals good membrane permeability properties and poor solubility in aqueo
Autor:
Ekaterina N. Domanina, Tatyana V. Volkova, Roman S. Kumeev, Alexey N. Proshin, Irina V. Terekhova
Publikováno v:
Journal of Molecular Liquids. 269:492-500
Solubility and permeability are the main parameters determining the bioavailability of drugs. In this study the increased solubility of novel 1,2,4-thiadiazole derivative (TDZ) proposed for the prevention and treatment of Alzheimer's disease was achi