Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Ekaterina M. Nestorovich"'
Publikováno v:
Toxins, Vol 6, Iss 8, Pp 2483-2540 (2014)
To intoxicate cells, pore-forming bacterial toxins are evolved to allow for the transmembrane traffic of different substrates, ranging from small inorganic ions to cell-specific polypeptides. Recent developments in single-channel electrical recording
Externí odkaz:
https://doaj.org/article/6c6be5cdc61f4fe39c3711f59b21fa3a
Autor:
Maurice Roeder, Ekaterina M. Nestorovich, Vladimir A. Karginov, Carsten Schwan, Klaus Aktories, Holger Barth
Publikováno v:
Toxins, Vol 6, Iss 7, Pp 2097-2114 (2014)
Some Clostridium difficile strains produce, in addition to toxins A and B, the binary toxin Clostridium difficile transferase (CDT), which ADP-ribosylates actin and may contribute to the hypervirulence of these strains. The separate binding and trans
Externí odkaz:
https://doaj.org/article/b8d79ebb23a2488bbc93329af4ab1bd8
Publikováno v:
Toxins, Vol 8, Iss 11, p 337 (2016)
Nearly all the cationic molecules tested so far have been shown to reversibly block K+ current through the cation-selective PA63 channels of anthrax toxin in a wide nM–mM range of effective concentrations. A significant increase in channel-blocking
Externí odkaz:
https://doaj.org/article/d1b21ea47b18493abba74be547ac423c
Publikováno v:
Biophysical Journal. 122:526a-527a
Autor:
Ekaterina M. Nestorovich, K. Ganapathy Ayappa, Stephen H. Leppla, Nnanya Kalu, Subbarao Kanchi, Prabal K. Maiti, Sanaz Momben Abolfath, Goli Yamini
Publikováno v:
The Journal of Physical Chemistry B. 125:5466-5478
"Pink" or 1/f noise is a natural phenomenon omnipresent in physics, economics, astrophysics, biology, and even music and languages. In electrophysiology, the stochastic activity of a number of biological ion channels and artificial nanopores could be
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1863(11)
Autor:
Michelle Kolberg, Sanaz Momben Abolfath, Vladimir A. Karginov, Stephen H. Leppla, Ekaterina M. Nestorovich
Publikováno v:
Biophys J
Obstructing conductive pathways of the channel-forming toxins with targeted blockers is a promising drug design approach. Nearly all tested positively charged ligands have been shown to reversibly block the cation-selective channel-forming protective
Autor:
Goli, Yamini, Subbarao, Kanchi, Nnanya, Kalu, Sanaz, Momben Abolfath, Stephen H, Leppla, K Ganapathy, Ayappa, Prabal K, Maiti, Ekaterina M, Nestorovich
Publikováno v:
The journal of physical chemistry. B. 125(21)
"Pink" or 1/
Autor:
Wenxing Liu, Ekaterina M. Nestorovich
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1863(11)
Protective antigen channel is the central component of the deadly anthrax exotoxin responsible for binding and delivery of the toxin's enzymatic lethal and edema factor components into the cytosol. The channel, which is more than three times longer t
Autor:
Wenxing Liu, Ekaterina M. Nestorovich
Publikováno v:
PROTEOMICS. 22:2100055
Neutral water-soluble poly(ethylene glycol)s (PEGs) have been extensively explored in protein nanopore research for the past several decades. The principal use of PEGs is to investigate the membrane protein ion channel physical characteristics and tr