Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ekaterina Kashkina"'
Autor:
Samuel J. Black, Ahmet Y. Ozdemir, Ekaterina Kashkina, Tatiana Kent, Timur Rusanov, Dejan Ristic, Yeonoh Shin, Antonio Suma, Trung Hoang, Gurushankar Chandramouly, Labiba A. Siddique, Nikita Borisonnik, Katherine Sullivan-Reed, Joseph S. Mallon, Tomasz Skorski, Vincenzo Carnevale, Katsuhiko S. Murakami, Claire Wyman, Richard T. Pomerantz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
DNA polymerase θ is a polymerase-helicase essential for microhomology-mediated end-joining (MMEJ) or alternative end-joining of DNA. Here the authors use biochemical and biophysical methods to reveal how full-length human DNA polymerase θ performs
Externí odkaz:
https://doaj.org/article/093c0d5069da4980a49ad192ca552eb0
Autor:
Gurushankar Chandramouly, Shuren Liao, Timur Rusanov, Nikita Borisonnik, Marissa L. Calbert, Tatiana Kent, Katherine Sullivan-Reed, Umeshkumar Vekariya, Ekaterina Kashkina, Tomasz Skorski, Hong Yan, Richard T. Pomerantz
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108820- (2021)
Summary: DNA polymerase θ (Polθ) confers resistance to chemotherapy agents that cause DNA-protein crosslinks (DPCs) at double-strand breaks (DSBs), such as topoisomerase inhibitors. This suggests Polθ might facilitate DPC repair by microhomology-m
Externí odkaz:
https://doaj.org/article/032b802c5b494e9997a34a69d6f7c32a
Autor:
Samuel J. Black, Ahmet Y. Ozdemir, Ekaterina Kashkina, Tatiana Kent, Timur Rusanov, Dejan Ristic, Yeonoh Shin, Antonio Suma, Trung Hoang, Gurushankar Chandramouly, Labiba A. Siddique, Nikita Borisonnik, Katherine Sullivan-Reed, Joseph S. Mallon, Tomasz Skorski, Vincenzo Carnevale, Katsuhiko S. Murakami, Claire Wyman, Richard T. Pomerantz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/2095b5f011424b1ca2cb0b1c21f0af4c
Autor:
OLEG KASHKIN, EKATERINA KASHKINA
Publikováno v:
VESTNIK ADVANCED TRAINING INSTITUTE OF THE MIA OF RUSSIA. :127-133
A brief analysis of the definition of the term "extremism" is presented. The article considers the manifestation of extremism given in scientific research against the background of historical events that took place from the time of Russia to the pres
Autor:
Zainab Shoda, Jeremy M. Stark, Nikita Borisonnik, Gurushankar Chandramouly, Jacklyn Huhn, Taylor Treddinick, Felicia Wednesday Lopezcolorado, Richard T. Pomerantz, Tatiana Kent, Joseph S. Mallon, Timur Rusanov, Ekaterina Kashkina, Labiba A. Siddique, Alessandra Brambati, Xiaojiang S. Chen, Trung Hoang, Jiemin Zhao, Shane McDevitt
Publikováno v:
Science Advances
Polθ reverse transcribes RNA by undergoing a significant conformational change and promotes RNA-templated DNA repair.
Genome-embedded ribonucleotides arrest replicative DNA polymerases (Pols) and cause DNA breaks. Whether mammalian DNA repair P
Genome-embedded ribonucleotides arrest replicative DNA polymerases (Pols) and cause DNA breaks. Whether mammalian DNA repair P
Autor:
Katsuhiko S. Murakami, Claire Wyman, Dejan Ristic, Antonio Suma, Joseph S. Mallon, Samuel J. Black, Ahmet Y. Ozdemir, Vincenzo Carnevale, Labiba A. Siddique, Timur Rusanov, Trung M. Hoang, Ekaterina Kashkina, Richard T. Pomerantz, Nikita Borisonnik, Gurushankar Chandramouly, Tomasz Skorski, Yeonoh Shin, Katherine Sullivan-Reed, Tatiana Kent
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications
Nature Communications
textabstractThe original version of this Article contained errors in Figure 6. In panel o, the labels incorrectly stated ‘Poleθ’ and “Poleθ + DNA” and should be labelled “Polθ” and “Polθ + DNA”. In the result section, in the sub-s
Autor:
Yeonoh Shin, Timur Rusanov, Claire Wyman, Ekaterina Kashkina, Joseph S. Mallon, Nikita Borisonnik, Ahmet Y. Ozdemir, Dejan Ristic, Katherine Sullivan-Reed, Richard T. Pomerantz, Katsuhiko S. Murakami, Vincenzo Carnevale, Labiba A. Siddique, Trung M. Hoang, Samuel J. Black, Tatiana Kent, Antonio Suma, Gurushankar Chandramouly, Tomasz Skorski
Publikováno v:
Nature Communications, 10:4423. Nature Publishing Group
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
DNA polymerase θ (Polθ) is a unique polymerase-helicase fusion protein that promotes microhomology-mediated end-joining (MMEJ) of DNA double-strand breaks (DSBs). How full-length human Polθ performs MMEJ at the molecular level remains unknown. Usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1057711c376c7eea3a5094762f597191
https://pure.eur.nl/en/publications/24e813b4-2919-44c8-beec-0e1f924747eb
https://pure.eur.nl/en/publications/24e813b4-2919-44c8-beec-0e1f924747eb
Autor:
Timur Rusanov, Tatiana Kent, Ekaterina Kashkina, Gurushankar Chandramouly, Tomasz Skorski, Marissa L. Calbert, Shuren Liao, Katherine Sullivan-Reed, Hong Yan, Nikita Borisonnik, Richard T. Pomerantz, Umeshkumar Vekariya
Publikováno v:
Cell reports
Cell Reports, Vol 34, Iss 10, Pp 108820-(2021)
Cell Reports, Vol 34, Iss 10, Pp 108820-(2021)
SUMMARY DNA polymerase θ (Polθ) confers resistance to chemotherapy agents that cause DNA-protein crosslinks (DPCs) at double-strand breaks (DSBs), such as topoisomerase inhibitors. This suggests Polθ might facilitate DPC repair by microhomology-me
Autor:
Richard T. Pomerantz, Tatiana Kent, Ekaterina Kashkina, Sarah K Deng, Agnel Sfeir, Pedro A. Mateos-Gómez, Trung M. Hoang, Shane McDevitt
Biochemical and cellular analyses reveal that the helicase activity of DNA polymerase theta (Polθ) antagonizes RPA to promote DNA strand annealing and double-strand break repair via alt-NHEJ in mouse ES cells. Mammalian polymerase theta (Polθ) is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46270d2b24c8c08a41fd68a54d8e3f93
https://europepmc.org/articles/PMC6047744/
https://europepmc.org/articles/PMC6047744/
Mammalian polymerase theta (Polθ; encoded by POLQ) is a unique multifunctional enzyme that promotes error-prone DNA repair by alternative-NHEJ (alt-NHEJ). Here we perform structure-function analyses and report that, in addition to the polymerase dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3355fb2324b56273b93f039c2d2e554