Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Ekaterina Chernogubova"'
Autor:
Serge Ducommun, Paulo R. Jannig, Igor Cervenka, Marta Murgia, Melanie J. Mittenbühler, Ekaterina Chernogubova, José M. Dias, Baptiste Jude, Jorge C. Correia, Jonathan G. Van Vranken, Gabriel Ocana-Santero, Margareta Porsmyr-Palmertz, Sarah McCann Haworth, Vicente Martínez-Redondo, Zhengye Liu, Mattias Carlström, Matthias Mann, Johanna T. Lanner, Ana I. Teixeira, Lars Maegdefessel, Bruce M. Spiegelman, Jorge L. Ruas
Publikováno v:
Molecular Metabolism, Vol 82, Iss , Pp 101912- (2024)
Objective: Skeletal muscle plasticity and remodeling are critical for adapting tissue function to use, disuse, and regeneration. The aim of this study was to identify genes and molecular pathways that regulate the transition from atrophy to compensat
Externí odkaz:
https://doaj.org/article/2abd30b26178418fbe5ccf30fb438f44
Autor:
Jessica Pauli, Tessa Reisenauer, Greg Winski, Nadja Sachs, Ekaterina Chernogubova, Hannah Freytag, Christoph Otto, Christian Reeps, Hans-Henning Eckstein, Claus-Jürgen Scholz, Lars Maegdefessel, Albert Busch
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1074 (2023)
Popliteal artery aneurysm (PAA) is the most frequent peripheral aneurysm, primarily seen in male smokers with a prevalence below 1%. This exploratory study aims to shed light on cellular mechanisms involved in PAA progression. Sixteen human PAA and e
Externí odkaz:
https://doaj.org/article/5a3b4a3811d74ba8b281dfc798a1ae6e
Autor:
Albert Busch, Jessica Pauli, Greg Winski, Sonja Bleichert, Ekaterina Chernogubova, Susanne Metschl, Hanna Winter, Matthias Trenner, Armin Wiegering, Christoph Otto, Johannes Fischer, Judith Reiser, Julia Werner, Joy Roy, Christine Brostjan, Christoph Knappich, Hans-Henning Eckstein, Valentina Paloschi, Lars Maegdefessel
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Abdominal aortic aneurysm (AAA) is a disease with high morbidity and mortality, especially when ruptured. The rationale of this study was to evaluate the repurposing of lenvatinib, a multi–tyrosine kinase inhibitor, in limiting experimental AAA gro
Externí odkaz:
https://doaj.org/article/aac1ee9249d0448ab8daa9aa9135c5d1
Autor:
Suzanne M. Eken, MD, PhD, Tinna Christersdottir, MD, Greg Winski, MD, Traimate Sangsuwan, MSc, Hong Jin, MD, PhD, Ekaterina Chernogubova, PhD, John Pirault, PhD, Changyan Sun, MSc, Nancy Simon, MSc, Hanna Winter, MSc, Alexandra Backlund, PhD, Siamak Haghdoost, PhD, Göran K. Hansson, MD, PhD, Martin Halle, MD, PhD, Lars Maegdefessel, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 1, Pp 72-82 (2019)
Summary: As a consequence of the success of present-day cancer treatment, radiotherapy-induced vascular disease is emerging. This disease is caused by chronic inflammatory activation and is likely orchestrated in part by microRNAs. In irradiated vers
Externí odkaz:
https://doaj.org/article/926ad42a8f694ea9b449c65f2a1f0718
Autor:
Greg Winski, Suzanne M. Eken, Ekaterina Chernogubova, Albert Busch, Hong Jin, Hanna Winter, Joshua M. Spin, Alexandra Bäcklund, Philip S. Tsao, Lars Maegdefessel
Publikováno v:
EJVES Vascular Forum, Vol 48, Iss , Pp 50- (2020)
Externí odkaz:
https://doaj.org/article/d78f5f35e922446fbed11e0a0667db2b
Publikováno v:
Journal of Diabetes Research, Vol 2013 (2013)
The rapid rise of type II diabetes mellitus and its accompanying vascular complications call for novel approaches in unravelling its pathophysiological mechanisms and designing new treatment modalities. Noncoding RNAs represent a class of previously
Externí odkaz:
https://doaj.org/article/b1814dd8d2694062a8622f46567635ba
Autor:
Albert Busch, Martin Busch, Claus-Jürgen Scholz, Richard Kellersmann, Christoph Otto, Ekaterina Chernogubova, Lars Maegdefessel, Alma Zernecke, Udo Lorenz
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 1, p 81 (2016)
Limited comprehension of aneurysm pathology has led to inconclusive results from clinical trials. miRNAs are key regulators of post-translational gene modification and are useful tools in elucidating key features of aneurysm pathogenesis in distinct
Externí odkaz:
https://doaj.org/article/ba6b84ffd8844e1e903a7f7c00062cdc
Autor:
Busch, Jessica Pauli, Tessa Reisenauer, Greg Winski, Nadja Sachs, Ekaterina Chernogubova, Hannah Freytag, Christoph Otto, Christian Reeps, Hans-Henning Eckstein, Claus-Jürgen Scholz, Lars Maegdefessel, Albert
Publikováno v:
Biomolecules; Volume 13; Issue 7; Pages: 1074
Popliteal artery aneurysm (PAA) is the most frequent peripheral aneurysm, primarily seen in male smokers with a prevalence below 1%. This exploratory study aims to shed light on cellular mechanisms involved in PAA progression. Sixteen human PAA and e
Autor:
Hanna Winter, Greg Winski, Albert Busch, Ekaterina Chernogubova, Francesca Fasolo, Zhiyuan Wu, Alexandra Bäcklund, Bohdan B. Khomtchouk, Derek J. Van Booven, Nadja Sachs, Hans-Henning Eckstein, Ilka Wittig, Reinier A. Boon, Hong Jin, Lars Maegdefessel
Publikováno v:
Molecular Therapy, 31(6), 1775-1790. Nature Publishing Group
Winter, H, Winski, G, Busch, A, Chernogubova, E, Fasolo, F, Wu, Z, Bäcklund, A, Khomtchouk, B B, van Booven, D J, Sachs, N, Eckstein, H-H, Wittig, I, Boon, R A, Jin, H & Maegdefessel, L 2023, ' Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression ', Molecular Therapy, vol. 31, no. 6, pp. 1775-1790 . https://doi.org/10.1016/j.ymthe.2023.04.020
Winter, H, Winski, G, Busch, A, Chernogubova, E, Fasolo, F, Wu, Z, Bäcklund, A, Khomtchouk, B B, van Booven, D J, Sachs, N, Eckstein, H-H, Wittig, I, Boon, R A, Jin, H & Maegdefessel, L 2023, ' Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression ', Molecular Therapy, vol. 31, no. 6, pp. 1775-1790 . https://doi.org/10.1016/j.ymthe.2023.04.020
Long non-coding RNAs (lncRNAs) orchestrate various biological processes and regulate the development of cardiovascular diseases. Their potential therapeutic benefit to tackle disease progression has recently been extensively explored. Our study inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f356f43f00e0abfc80c908e94e76cf9
https://research.vumc.nl/en/publications/c9722334-41bc-42dc-b138-084b309945e2
https://research.vumc.nl/en/publications/c9722334-41bc-42dc-b138-084b309945e2
Autor:
Marlys L. Koschinsky, Sabine Bauer, Zhiyuan Wu, Oliver Soehnlein, Jessica Pauli, Ljubica Perisic Matic, Hanna Winter, W.E. Kempf, Greg Winski, Ulf Hedin, Valentina Paloschi, Hans-Henning Eckstein, Nadiya Glukha, Ekaterina Chernogubova, Lars Maegdefessel, Hong Jin, Daniel Y. Li, Muredach P. Reilly, Francesca Fasolo, Claes Bergmark, Alexandra Bäcklund, Susanne Metschl, Jaroslav Pelisek
Publikováno v:
Circulation. 144:1567-1583
Background: Long noncoding RNAs (lncRNAs) are important regulators of biological processes involved in vascular tissue homeostasis and disease development. The present study assessed the functional contribution of the lncRNA myocardial infarction-ass