Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Ekaterina Breous"'
Autor:
Estelle Marrer-Berger, Annalisa Nicastri, Angelique Augustin, Vesna Kramar, Hanqing Liao, Lydia Jasmin Hanisch, Alejandro Carpy, Tina Weinzierl, Evelyne Durr, Nathalie Schaub, Ramona Nudischer, Daniela Ortiz-Franyuti, Ekaterina Breous-Nystrom, Janick Stucki, Nina Hobi, Giulia Raggi, Lauriane Cabon, Emmanuelle Lezan, Pablo Umaña, Isaac Woodhouse, Alexander Bujotzek, Christian Klein, Nicola Ternette
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Selective binding of TCR-like antibodies that target a single tumour-specific peptide antigen presented by human leukocyte antigens (HLA) is the absolute prerequisite for their therapeutic suitability and patient safety. To date, selectivity
Externí odkaz:
https://doaj.org/article/1e7a4a6f3006436c814053de1558d191
Autor:
S Jordan Kerns, Chaitra Belgur, Debora Petropolis, Marianne Kanellias, Riccardo Barrile, Johannes Sam, Tina Weinzierl, Tanja Fauti, Anne Freimoser-Grundschober, Jan Eckmann, Carina Hage, Martina Geiger, Patrick Ray Ng, William Tien-Street, Dimitris V Manatakis, Virginie Micallef, Regine Gerard, Michael Bscheider, Ekaterina Breous-Nystrom, Anneliese Schneider, Anna Maria Giusti, Cristina Bertinetti-Lapatki, Heather Shannon Grant, Adrian B Roth, Geraldine A Hamilton, Thomas Singer, Katia Karalis, Annie Moisan, Peter Bruenker, Christian Klein, Marina Bacac, Nikolce Gjorevski, Lauriane Cabon
Publikováno v:
eLife, Vol 10 (2021)
Traditional drug safety assessment often fails to predict complications in humans, especially when the drug targets the immune system. Here, we show the unprecedented capability of two human Organs-on-Chips to evaluate the safety profile of T-cell bi
Externí odkaz:
https://doaj.org/article/65e3b07242e4472a8bccea9ce9f5ca1b
Autor:
Michal Rudnik, Ozlem Yavaş Grining, Simon Hutter, Frauke Greve, Daniela Ortiz Franyuti, Ramona Matheis, Ekaterina Breous-Nystrom, Olivier Frey
Publikováno v:
Cancer Research. 83:2747-2747
The superior clinical therapeutic effects and broad applications of bispecific T cell engagers (BiTEs) has transformed treatment strategies in oncology. While benefits of the novel immunotherapies are indisputable, the safety aspects require to be in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe5a21a32cdb2dad4aa70b499c7604e2
https://doi.org/10.1158/1538-7445.am2023-2747
https://doi.org/10.1158/1538-7445.am2023-2747
Autor:
Randi B Gombos, Ana Gonzalez, Mariana Manrique, Dhan Chand, David Savitsky, Benjamin Morin, Ekaterina Breous-Nystrom, Christopher Dupont, Rebecca A Ward, Cornelia Mundt, Benjamin Duckless, Hao Tang, Mark A Findeis, Andrea Schuster, Jeremy D Waight, Dennis Underwood, Christopher Clarke, Gerd Ritter, Taha Merghoub, David Schaer, Jedd D Wolchok, Marc van Dijk, Jennifer S Buell, Jean-Marie Cuillerot, Robert Stein, Elise E Drouin, Nicholas S Wilson
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0191926 (2018)
CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen-specific T cells with antigen-presenting cells. Anti-CTLA-4 antibodies enhance tumor-specific immunity through a variety o
Externí odkaz:
https://doaj.org/article/a2c5e638342c4ecea28b08aa00701413
Autor:
Estelle Marrer-Berger, Thierry Lavé, Thomas Singer, Adrian Roth, Sven Kronenberg, Ekaterina Breous-Nystrom
Publikováno v:
Current Opinion in Toxicology. :39-45
The advances in the immunotherapy field in the last decade have enabled efficient treatment of previously intractable cancers. These advances have also exposed the limitations of commonly used animal models for safety prediction of such drugs. In fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19ca55232a1d8b43318a4e8b39b31d58
https://doi.org/10.1016/j.cotox.2020.03.002
https://doi.org/10.1016/j.cotox.2020.03.002
Autor:
Anne Freimoser-Grundschober, Ekaterina Breous-Nystrom, Heather Shannon Grant, Chaitra Belgur, Carina Hage, Anna Maria Giusti, Régine Gérard, Patrick Ray Ng, Martina Geiger, Lauriane Cabon, Adrian Roth, Katia Karalis, Nikolce Gjorevski, Tanja Fauti, Dimitris V. Manatakis, Johannes Sam, Christian Klein, William Tien-Street, Tina Weinzierl, Virginie Micallef, Thomas Singer, Anneliese Schneider, Debora B. Petropolis, Annie Moisan, Peter Bruenker, Jan Eckmann, Geraldine A. Hamilton, S. Jordan Kerns, Cristina Bertinetti-Lapatki, Riccardo Barrile, Michael Bscheider, Marina Bacac, Marianne Kanellias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3636b0fb4a5bf02fa3e3ab9b2eb29a8
https://doi.org/10.7554/elife.67106.sa2
https://doi.org/10.7554/elife.67106.sa2
Autor:
Katia Karalis, Anneliese Schneider, Riccardo Barrile, Annie Moisan, Peter Bruenker, William Tien-Street, Michael Bscheider, Patrick Ray Ng, Régine Gérard, Tanja Fauti, Anna Maria Giusti, Debora B. Petropolis, Ekaterina Breous-Nystrom, Marina Bacac, Johannes Sam, Thomas Singer, Adrian Roth, Nikolce Gjorevski, Tina Weinzierl, Virginie Micallef, Lauriane Cabon, Dimitris V. Manatakis, Carina Hage, Cristina Bertinetti-Lapatki, Jan Eckmann, Geraldine A. Hamilton, Christian Klein, S. Jordan Kerns, Chaitra Belgur, Marianne Kanellias, Anne Freimoser-Grundschober, Heather Shannon Grant, Martina Geiger
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Traditional drug safety assessment often fails to predict complications in humans, especially when the drug targets the immune system. Here, we show the unprecedented capability of two Organs-on-Chips to evaluate the safety profile of T-cell bispecif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0bc505b8f7bce39068eca295b02de7
https://pubmed.ncbi.nlm.nih.gov/34558412
https://pubmed.ncbi.nlm.nih.gov/34558412
Autor:
Nuria Roldan, Giulia Raggi, Nina Hobi, Lea De Maddalena, Ralph A. Schmid, Théo Imler, Laurène Froment, Ekaterina Breous-Nystrom, Aude Rapet, Thomas M. Marti, Virginie Micallef, Lauriane Cabon, Adrian Roth
Publikováno v:
Airway cell biology and immunopathology.
Systemic administration of Interleukin-2 (IL-2) at high doses in cancer immunotherapy has been associated with vascular leak syndrome (VLS) and pulmonary edema, a life-threatening condition. The complex mechanism of action underlying this medication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ae2f222b2049a2a4592420285194748
https://doi.org/10.1183/13993003.congress-2020.4326
https://doi.org/10.1183/13993003.congress-2020.4326
Autor:
Dhan Chand, Benjamin Morin, Jennifer Buell, Ekaterina Breous-Nystrom, Jeremy D. Waight, Jedd D. Wolchok, Taha Merghoub, Elise Drouin, Nicholas S. Wilson, Christopher Clarke, Marc Van Dijk, Christopher D. Dupont, Cornelia Anne Mundt, David Savitsky, Andrea Schuster, Mark Findeis, Dennis J. Underwood, Benjamin Duckless, Mariana Manrique, Rebecca Ward, Gerd Ritter, Randi Gombos, Ana M. Martín González, Robert Stein, Jean Marie Cuillerot, Hao Tang, David Schaer
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0191926 (2018)
PLoS ONE
PLoS ONE
CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen-specific T cells with antigen-presenting cells. Anti-CTLA-4 antibodies enhance tumor-specific immunity through a variety o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3531cae0cd1ba02aea8a8ea663edeca
http://europepmc.org/articles/PMC5884502?pdf=render
http://europepmc.org/articles/PMC5884502?pdf=render
Autor:
Joseph Connolly, Robert Stein, Reid Huber, Nicholas S. Wilson, Ekaterina Breous-Nystrom, Mark Findeis, Priyadarshini Iyer, Marc van Dijk, Peggy Scherle, Dennis J. Underwood, Christina Riordan, Horacio Nastri, Gregory Hollis, Michele Sanicola-Nadel, Jeremy D. Waight
Publikováno v:
Cancer Research. 78:3825-3825
Unprecedented rates of durable clinical responses have been observed for antibody-based therapeutics targeting immune checkpoint proteins such as cytotoxic T lymphocyte antigen-4 (CTLA-4) or programmed death receptor-1 (PD-1). Nonetheless, a signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::766eec68416fd0db980bd6a9f209b143
https://doi.org/10.1158/1538-7445.am2018-3825
https://doi.org/10.1158/1538-7445.am2018-3825