Histone variant H3.3 residue S31 is essential for Xenopus gastrulation regardless of the deposition pathway

Autor: David Sitbon, Ekaterina Boyarchuk, Florent Dingli, Damarys Loew, Geneviève Almouzni

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Replicative and non-replicative H3 variants have different cell cycle regulation and incorporation modes. Here, the authors identify H3.3 S31 deposition as key at Xenopus gastrulation, independently of the pathways; and characterize H3.3 S31 phosphor

Externí odkaz: https://doaj.org/article/6b6fa19d666d4ac597e0b95866bcdfb9

Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit

Autor: Dominique Ray-Gallet, M. Daniel Ricketts, Yukari Sato, Kushol Gupta, Ekaterina Boyarchuk, Toshiya Senda, Ronen Marmorstein, Geneviève Almouzni

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

The HIRA histone chaperone complex is involved in the deposition of the histone variant H3.3. Here the authors, by using biochemical and crystallographic approaches, report the homotrimerization of the HIRA subunit which is critical for the functiona

Externí odkaz: https://doaj.org/article/71022acda3b54be6ad946c83a4006f44

Two distinct HIRA-dependent pathways handle H3.3 de novo deposition and recycling during transcription

Autor: Geneviève Almouzni, Ekaterina Boyarchuk, Guillermo A. Orsi, Antoine Coulon, Mickaël Garnier, Dominique Ray-Gallet, Júlia Torné

The packaging of DNA into nucleosomes represents a challenge for transcription. Nucleosome disruption and histone eviction enables RNA Polymerase II progression through DNA, a process that compromises chromatin integrity and the maintenance of epigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f526b577c09a8319803452570ab4bf

Metabolic Deregulations Affecting Chromatin Architecture: One-Carbon Metabolism and Krebs Cycle Impact Histone Methylation

Autor: Ekaterina Boyarchuk, Francisco Saavedra, Francisca Alvarez, Geneviève Almouzni, Alejandra Loyola

Publikováno v: The DNA,RNA, and Histone Methylomes. RNA Technologies.
The DNA,RNA, and Histone Methylomes. RNA Technologies., pp.573-606, 2019, 978-3-030-14791-4. ⟨10.1007/978-3-030-14792-1_23⟩
The DNA, RNA, and Histone Methylomes
The DNA,RNA, and Histone Methylomes. RNA Technologies., RNATECHN, pp.573-606, 2019, 978-3-030-14791-4. ⟨10.1007/978-3-030-14792-1_23⟩
RNA Technologies
RNA Technologies-The DNA, RNA, and Histone Methylomes
RNA Technologies ISBN: 9783030147914

International audience; The methylation status of a particular amino acid results from the interplay of two enzymes: “Writers” (methyltransferases) and “Erasers” (demethylases). Methylation of histones in chromatin can be recognized by “Rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4234d4a247b504fa9c645069456f74d
https://hal.archives-ouvertes.fr/hal-02371144

Conception sur une base rationnelle de peptides de haute affinité inhibant l'histone chaperon ASF1

Autor: Carl Mann, Raphael Guerois, May Bakail, Ekaterina Boyarchuk, Albane Gaubert, Marie-Cécile Gaillard, Zachary A. Gurard-Levin, Françoise Ochsenbein, Brice Murciano, Claire Frederic, Gwenaëlle Moal, Geneviève Almouzni, Jean-Yves Thuret, Régis Courbeyrette, Morgane Agez, Marie-Hélène Le Du, Nicolas Richet, Jessica Andreani, Adeline Poitou, Nadia Cherradi, Berengère Guichard, Guillaume Pinna, Caroline Roelants

Publikováno v: Cell Chemical Biology
Cell Chemical Biology, 2019, ⟨10.1016/j.chembiol.2019.09.002⟩
Cell Chemical Biology, Cell Press, 2019, 26 (11), pp.1573-1585.e10. ⟨10.1016/j.chembiol.2019.09.002⟩
Cell Chemical Biology, 2019, 26 (11), pp.1573-1585.e10. ⟨10.1016/j.chembiol.2019.09.002⟩

International audience; Anti-silencing function 1 (ASF1) is a conserved H3-H4 histone chaperone involved in histone dynamics during replication, transcription, and DNA repair. Overexpressed in proliferating tissues including many tumors, ASF1 has eme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e363462fa67802e4c07a173d447801b2
https://hal.archives-ouvertes.fr/hal-02301617