Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Ekaterina, Savchenko"'
Autor:
Erika Velasquez, Ekaterina Savchenko, Sara Marmolejo-Martínez-Artesero, Désiré Challuau, Aline Aebi, Yuriy Pomeshchik, Nuno Jorge Lamas, Mauno Vihinen, Melinda Rezeli, Bernard Schneider, Cedric Raoul, Laurent Roybon
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106687- (2024)
Astrocytes play a crucial role in the onset and progression of amyotrophic lateral sclerosis (ALS), a fatal disorder marked by the degeneration of motor neurons (MNs) in the central nervous system. Although astrocytes in ALS are known to be toxic to
Externí odkaz:
https://doaj.org/article/96141882157d42c4b7a55ed53795b7d5
Autor:
Sohvi Ohtonen, Luca Giudice, Henna Jäntti, Mohammad Feroze Fazaludeen, Anastasia Shakirzyanova, Mireia Gómez-Budia, Nelli-Noora Välimäki, Jonna Niskanen, Nea Korvenlaita, Ilkka Fagerlund, Jari Koistinaho, Mahmood Amiry-Moghaddam, Ekaterina Savchenko, Laurent Roybon, Šárka Lehtonen, Paula Korhonen, Tarja Malm
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract LRRK2-G2019S is one of the most common Parkinson’s disease (PD)-associated mutations and has been shown to alter microglial functionality. However, the impact of LRRK2-G2019S on transcriptional profile of human induced pluripotent stem cel
Externí odkaz:
https://doaj.org/article/cbf0d639bf06480ebb4d53aab63905d3
Autor:
Svetlana Pavlova, Lika Fab, Ekaterina Savchenko, Anastasia Ryabova, Marina Ryzhova, Alexander Revishchin, Igor Pronin, Dmitry Usachev, Alexey Kopylov, Galina Pavlova
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 74 (2024)
High-grade gliomas are considered an incurable disease. Despite all the various therapy options available, patient survival remains low, and the tumor usually returns. Tumor resistance to conventional therapy and stimulation of the migratory activity
Externí odkaz:
https://doaj.org/article/c78b2176e2c147609c5634eb004ac42c
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-6 (2021)
Abstract Recent studies suggest that brain cell type specific intracellular environments may play important roles in the generation of structurally different protein aggregates that define neurodegenerative diseases. Using human induced pluripotent s
Externí odkaz:
https://doaj.org/article/53851b3c6282414381aae42ec9308475
Autor:
Galina Pavlova, Alexandra Belyashova, Ekaterina Savchenko, Dmitri Panteleev, Dzhirgala Shamadykova, Anna Nikolaeva, Svetlana Pavlova, Alexander Revishchin, Denis Golbin, Alexander Potapov, Natalia Antipina, Andrey Golanov
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Radiation therapy induces double-stranded DNA breaks in tumor cells, which leads to their death. A fraction of glioblastoma cells repair such breaks and reinitiate tumor growth. It was necessary to identify the relationship between high radiation dos
Externí odkaz:
https://doaj.org/article/7ef7ab58fac146b8934f26e7e7595a53
Autor:
Meike Hedwig Keuters, Velta Keksa-Goldsteine, Hiramani Dhungana, Mikko T. Huuskonen, Yuriy Pomeshchik, Ekaterina Savchenko, Paula K. Korhonen, Yajuvinder Singh, Sara Wojciechowski, Šárka Lehtonen, Katja M. Kanninen, Tarja Malm, Jouni Sirviö, Anu Muona, Milla Koistinaho, Gundars Goldsteins, Jari Koistinaho
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Lipid peroxidation-initiated ferroptosis is an iron-dependent mechanism of programmed cell death taking place in neurological diseases. Here we show that a condensed benzo[b]thiazine derivative small molecule with an arylthiazine backbone (A
Externí odkaz:
https://doaj.org/article/3ca87910b4fe497bb6a795384b53ddb2
Autor:
Nadia Skauli, Ekaterina Savchenko, Ole Petter Ottersen, Laurent Roybon, Mahmood Amiry-Moghaddam
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Aquaporin-4 (AQP4) is the predominant water channel in the brain; it is enriched in astrocytic foot processes abutting vessels where it is anchored through an interaction with the dystrophin-associated protein (DAP) complex. Enhanced expression with
Externí odkaz:
https://doaj.org/article/91afdf84fb3844ef87597814d1cccf61
Autor:
Paula Korhonen, Eveliina Pollari, Katja M. Kanninen, Ekaterina Savchenko, Šárka Lehtonen, Sara Wojciechowski, Yuriy Pomeshchik, Ludo Van Den Bosch, Gundars Goldsteins, Jari Koistinaho, Tarja Malm
Publikováno v:
IBRO Reports, Vol 6, Iss , Pp 74-86 (2019)
Inflammation is a prominent feature of the neuropathology of amyotrophic lateral sclerosis (ALS). Emerging evidence suggests that inflammatory cascades contributing to the disease progression are not restricted to the central nervous system (CNS) but
Externí odkaz:
https://doaj.org/article/02325ea1922447b59859bac28b3eff53
Autor:
Kaspar Russ, Gabriel Teku, Luc Bousset, Virginie Redeker, Sara Piel, Ekaterina Savchenko, Yuriy Pomeshchik, Jimmy Savistchenko, Tina C. Stummann, Carla Azevedo, Anna Collin, Stefano Goldwurm, Karina Fog, Eskil Elmer, Mauno Vihinen, Ronald Melki, Laurent Roybon
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108895- (2021)
Summary: Here, we examine the cellular changes triggered by tumor necrosis factor alpha (TNF-α) and different alpha-synuclein (αSYN) species in astrocytes derived from induced pluripotent stem cells. Human astrocytes treated with TNF-α display a s
Externí odkaz:
https://doaj.org/article/6a50af0ea3c9434abf2f85506059fa63
Autor:
Carla Azevedo, Margarita Chumarina, Evgenija Serafimova, Stefano Goldwurm, Anna Collin, Laurent Roybon, Ekaterina Savchenko, Yuriy Pomeshchik
Publikováno v:
Stem Cell Research, Vol 43, Iss , Pp - (2020)
Here, we describe the generation of an induced pluripotent stem cell (iPSC) line, from a male patient diagnosed with Parkinson's disease (PD). The patient carries a heterozygous variation p.A53T in the SNCA gene. Skin fibroblasts were reprogrammed us
Externí odkaz:
https://doaj.org/article/cd8b01eba06b4fadaf57462636202ac4