Výsledky vyhledávání - "Ekampreet, Singh"

Akademický článek

Identification and prioritization of potential therapeutic molecules against LpxA from Acinetobacter baumannii – A computational study

Autor: Rameez Jabeer Khan, Ekampreet Singh, Rajat Kumar Jha, Ankit Kumar, Saurabh Kumar Bhati, Mahrukh Parveez Zia, Monika Jain, Rashmi Prabha Singh, Jayaraman Muthukumaran, Amit Kumar Singh

Publikováno v: Current Research in Structural Biology, Vol 5, Iss , Pp 100096- (2023)

A. baumannii is a ubiquitously found gram-negative, multi-drug resistant bacterial species from the ESKAPE family of pathogens known to be the causative agent for hospital-acquired infections such as pneumonia, meningitis, endocarditis, septicaemia a

Externí odkaz: https://doaj.org/article/ce58681dfa544474863fddaa482716b5

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Akademický článek

A comprehensive review on promising anti-viral therapeutic candidates identified against main protease from SARS-CoV-2 through various computational methods

Autor: Ekampreet Singh, Rameez Jabeer Khan, Rajat Kumar Jha, Gizachew Muluneh Amera, Monika Jain, Rashmi Prabha Singh, Jayaraman Muthukumaran, Amit Kumar Singh

Publikováno v: Journal of Genetic Engineering and Biotechnology, Vol 18, Iss 1, Pp 1-12 (2020)

Abstract Background The COVID-19 pandemic caused by SARS-CoV-2 has shown an exponential trend of infected people across the planet. Crediting its virulent nature, it becomes imperative to identify potential therapeutic agents against the deadly virus

Externí odkaz: https://doaj.org/article/972092af561240cbaf37ef3f69487358

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Structural and functional characterization of 1-deoxy-D-xylulose-5-phosphate synthase (DXS) from Acinetobacter baumannii: identification of promising lead molecules from virtual screening, molecular docking and molecular dynamics simulations

Autor: Mahrukh Parveez Zia, Ekampreet Singh, Monika Jain, Jayaraman Muthukumaran, Amit Kumar Singh

The advent of multi drug resistance and extensive-drug resistance among various pathogens has caused a rise in nosocomial infections, which in turn has led to rising hospital-acquired infection-related mortality rates. Amongst them, carbapenem-resist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a671bbf4f64b1a1380fd99a0855deca

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Identifying the natural compound Catechin from tropical mangrove plants as a potential lead candidate against 3CLpro from SARS-CoV-2: An integrated in silico approach

Autor: A. Parthiban, Rajat Kumar Jha, Purvaja Ramachandran, V. Sachithanandam, Gizachew Muluneh Amera, Jayaraman Muthukumaran, Ekampreet Singh, Ramesh Ramachandran, Rashmi Singh, Monika Jain, Rameez Jabeer Khan, Amit Kumar Singh

Publikováno v: Journal of Biomolecular Structure and Dynamics. 40:13392-13411

SARS-CoV-2, a member of beta coronaviruses, is a single-stranded, positive-sense RNA virus responsible for the COVID-19 pandemic. With global fatalities of the pandemic exceeding 4.57 million, it becomes crucial to identify effective therapeutics aga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd985fbb895ede06e7182624fa5e4f49
https://doi.org/10.1080/07391102.2021.1988710

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Droperidol as a potential inhibitor of acyl-homoserine lactone synthase from A. baumannii: insights from virtual screening, MD simulations and MM/PBSA calculations

Autor: Rajat Kumar Jha, Ekampreet Singh, Rameez Jabeer Khan, Ankit Kumar, Monika Jain, Jayaraman Muthukumaran, Amit Kumar Singh

Publikováno v: Molecular Diversity.

A. baumannii belongs to the ESKAPE family of pathogens and is a multi-drug resistant, gram-negative bacteria which follows the anaerobic form of respiration. A. baumannii is known to be the causative agent of hospital-related infections such as pneum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd529b0a7b1c0ae2fe8a801d57a5b762
https://doi.org/10.1007/s11030-022-10533-2

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Targeting SARS-CoV-2: a systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2′-O-ribose methyltransferase

Autor: Rajat Kumar Jha, Amit Kumar Singh, Rashmi Singh, Rameez Jabeer Khan, Jayaraman Muthukumaran, Gizachew Muluneh Amera, Amita Pathak, Ekampreet Singh, Monika Jain

Publikováno v: Journal of Biomolecular Structure & Dynamics
Journal of Biomolecular Structure and Dynamics

The recent pandemic associated with SARS-CoV-2, a virus of the Coronaviridae family, has resulted in an unprecedented number of infected people. The highly contagious nature of this virus makes it imperative for us to identify promising inhibitors fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c3848d8e154275455bc9cb73466b82
http://europepmc.org/articles/PMC7189412

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An extensive computational study to identify potential inhibitors of Acyl-homoserine-lactone synthase from Acinetobacter baumannii (strain AYE)

Autor: Rajat Kumar Jha, Rameez Jabeer Khan, Ekampreet Singh, Ankit Kumar, Monika Jain, Jayaraman Muthukumaran, Amit Kumar Singh

Publikováno v: Journal of molecular graphicsmodelling. 114

A member of the ESKAPE family of pathogens, A. baumannii, is an opportunistic gram-negative multidrug-resistant bacterium. A. baumannii is a ubiquitous coccobacillus involved in various hospital-related infections such as wound infections, pneumonia,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9445d1740a990e0f9e2cdca37ecf13b6
https://pubmed.ncbi.nlm.nih.gov/35339024

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