Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Ekambar R. Kandimalla"'
Autor:
Sudhir Agrawal, Ekambar R. Kandimalla
Publikováno v:
Immuno-Oncology and Technology, Vol 3, Iss , Pp 15-23 (2019)
Recently, it has become clear that the tumour microenvironment (TME) is important in cancer immunotherapy. While immune checkpoint inhibitors are effective for some patients, the heterogeneous nature and status of the TME (‘cold’ tumours) play a
Externí odkaz:
https://doaj.org/article/0d407eb3b638492c83aac3c4f74ee406
Autor:
Sudhir Agrawal, Ekambar R. Kandimalla, Jimmy X. Tang, Dong Yu, Tao Lan, Melissa Precopio, Daqing Wang
Viral and synthetic single-stranded RNAs are the ligands for Toll-like receptors 7 and 8 (TLR7 and TLR8). We have reported a novel class of synthetic oligoribonucleotides, referred to as stabilized immune-modulatory RNA compounds, which act as agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3359f37bace781823b119113ff4406ce
https://doi.org/10.1158/1535-7163.c.6531882.v1
https://doi.org/10.1158/1535-7163.c.6531882.v1
Autor:
Sudhir Agrawal, Ekambar R. Kandimalla, Jimmy X. Tang, Dong Yu, Tao Lan, Melissa Precopio, Daqing Wang
Supplementary Table from Antitumor Activity and Immune Response Induction of a Dual Agonist of Toll-Like Receptors 7 and 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843bb57c9780527c875eb8fef6c2c748
https://doi.org/10.1158/1535-7163.22485297
https://doi.org/10.1158/1535-7163.22485297
Autor:
Ekambar R. Kandimalla, Sudhir Agrawal
Publikováno v:
Immuno-Oncology and Technology, Vol 3, Iss, Pp 15-23 (2019)
Recently, it has become clear that the tumour microenvironment (TME) is important in cancer immunotherapy. While immune checkpoint inhibitors are effective for some patients, the heterogeneous nature and status of the TME (‘cold' tumours) play a cr
Autor:
Subhrajit Saha, Payel Bhanja, Laibin Liu, Alan A Alfieri, Dong Yu, Ekambar R Kandimalla, Sudhir Agrawal, Chandan Guha
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29357 (2012)
Radiation-induced gastrointestinal syndrome (RIGS) is due to the clonogenic loss of crypt cells and villi depopulation, resulting in disruption of mucosal barrier, bacterial invasion, inflammation and sepsis. Intestinal macrophages could recognize in
Externí odkaz:
https://doaj.org/article/7d727bfc45c64adc8bdfcf2efb88765a
Autor:
Huagang Zhang, Laibin Liu, Dong Yu, Ekambar R Kandimalla, Hui Bin Sun, Sudhir Agrawal, Chandan Guha
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38111 (2012)
PURPOSE:Recent studies have shown that a new generation of synthetic agonist of Toll-like receptor (TLR) 9 consisting a 3'-3'-attached structure and a dCp7-deaza-dG dinucultodie shows more potent immunostimulatory effects in both mouse and human than
Externí odkaz:
https://doaj.org/article/b653bfa7812e43dcb840e58fc688f522
Publikováno v:
Cancer Research. 81:1706-1706
CpG-oligodeoxynucleotides (CpG ODNs) are known ligands of innate immune receptor, toll-like receptor 9 (TLR9). Activation of TLR9 by its ligands leads to stimulation of an immune cascade represented by secretion of Th1-type cytokine and chemokine mil
Autor:
Sudhir Agrawal, Ekambar R. Kandimalla
Publikováno v:
Advances in Nucleic Acid Therapeutics ISBN: 9781788012096
Toll-like receptors (TLRs) 7, 8, and 9 are expressed in the endosomes of immune cells, recognize nucleic acid molecular patterns of viruses and bacteria, and induce innate and adaptive immune responses to the infections. While this immune surveillanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a27d8e1332a03f6ee1ed52ded92b72d6
https://doi.org/10.1039/9781788015714-00080
https://doi.org/10.1039/9781788015714-00080
Autor:
Sudhir Agrawal, Ekambar R. Kandimalla
Publikováno v:
Advances in Nucleic Acid Therapeutics ISBN: 9781788012096
In recent years a number of innate immune receptors, such as retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), absent in melanoma 2 (AIM2)-like receptors (ALRs), stimulator of interferon genes (STING), nucleotide oligomerization domain (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a59745b6be1aa9e65003970164e59a59
https://doi.org/10.1039/9781788015714-00306
https://doi.org/10.1039/9781788015714-00306
Autor:
Richard Kang, Henry C. Marsh, Ekambar R. Kandimalla, Lauren E. Gergel, Tibor Keler, Li-Zhen He, Bart R. Anderson, James M. Boyer, Eric M. Forsberg, Kathleen M. Borrelli, Jeffrey Weidlick, Lawrence J. Thomas, Mallary Rocheleau, April R. Baronas, Anna Wasiuk, Subbarao Nallagatla, Elizabeth Q. Do
Publikováno v:
Cancer Research. 79:3217-3217
Recent studies have highlighted the critical role of CD103+/CD141+ dendritic cells (DCs) in antitumor immunity. CDX-301 is a soluble, recombinant human FLT3 ligand (Flt3L). Flt3L is a hematopoietic cytokine which stimulates the proliferation and diff