Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ek Raj Thapaliya"'
Autor:
Ek Raj Thapaliya, Syed Muhammad Usama, Nimit L. Patel, Yang Feng, Joseph D. Kalen, Brad St. Croix, Martin J. Schnermann
Publikováno v:
Bioconjugate Chemistry. 33:718-725
Conjugates of small molecules and antibodies are broadly employed diagnostic and therapeutic agents. Appending a small molecule to an antibody often significantly impacts the properties of the resulting conjugate. Here, we detail a systematic study i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c228b1c47108255054708ca4cf527576
https://doi.org/10.1021/acs.bioconjchem.2c00083
https://doi.org/10.1021/acs.bioconjchem.2c00083
Autor:
Benjamin Serraz, Ek Raj Thapaliya, Graham C. R. Ellis-Davies, Pierre Paoletti, Laetitia Mony, Roberto Sanchez
Publikováno v:
ChemPhotoChem
Ifenprodil is an important negative allosteric modulator of the N-methyl-D-aspartate (NMDA) receptors. We have synthesized caged and photoswitchable derivatives of this small molecule drug. Caged ifenprodil was biologically inert before photolysis, U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254940bf52775bc8c7cddf772c2f93b9
https://doi.org/10.1002/cptc.202000240
https://doi.org/10.1002/cptc.202000240
Publikováno v:
ChemPhotoChem. 4:332-337
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d62d67563e7c42f95c7c09aad0371d
https://doi.org/10.1002/cptc.201900276
https://doi.org/10.1002/cptc.201900276
Publikováno v:
Curr Opin Chem Biol
The combination of targeting ligands and fluorescent dyes is a powerful strategy to observe cell types and tissues of interest. Conjugates of peptides, proteins, and, in particular, monoclonal antibodies (mAbs) exhibit excellent tumor targeting in va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830ae7cc3c51858c33d74518031a54d2
https://europepmc.org/articles/PMC8384635/
https://europepmc.org/articles/PMC8384635/
Publikováno v:
The Journal of Physiology. 596:5307-5318
Key points A new caged nicotinic acetylcholine receptor (nAChR) agonist was developed, ABT594, which is photolysed by one- and two-photon excitation. The caged compound is photolysed with a quantum yield of 0.20. One-photon uncaging of ABT594 elicite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e60d733c0782840b4655ddf1fbd2f8ba
https://doi.org/10.1113/jp276615
https://doi.org/10.1113/jp276615
Publikováno v:
Chemical Communications. 54:8799-8809
The identification of operating principles to activate fluorescence under the influence of external stimulations is essential to enable the implementation of imaging strategies requiring the spatiotemporal control of emission. In this context, our la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca4a4743c2ef3935257581c71f87f4f
https://doi.org/10.1039/c8cc03094d
https://doi.org/10.1039/c8cc03094d
Publikováno v:
Inorganica Chimica Acta. 468:82-90
The coupling of visible radiation with the surface plasmon of silver nanoparticles (AgNPs) results in a significant enhancement of the electromagnetic field in close proximity to the surface of the metal nanoconstructs. Such an enhancement can be exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68902bd1acc041d7a98f60cbc20e1e34
https://doi.org/10.1016/j.ica.2017.05.023
https://doi.org/10.1016/j.ica.2017.05.023
Autor:
Pravat Dhakal, Yang Zhang, Ek Raj Thapaliya, James N. Wilson, Kevin M. Collins, Adrienne S. Brown, Françisco M. Raymo
Publikováno v:
Bioconjugate Chemistry. 28:1519-1528
Seven macromolecular constructs incorporating multiple borondipyrromethene (BODIPY) fluorophores along a common poly(methacrylate) backbone with decyl and oligo-(ethylene glycol) side chains were synthesized. The hydrophilic oligo(ethylene glycol) co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032e673c1295f636d5707555efde87b5
https://doi.org/10.1021/acs.bioconjchem.7b00166
https://doi.org/10.1021/acs.bioconjchem.7b00166
Publikováno v:
Journal of Materials Chemistry C. 5:1179-1183
The photoinduced cleavage of oxazine heterocycles, connected to macromolecules spin coated on appropriate substrates, occurs efficiently and irreversibly. The products of this photochemical transformation quench effectively the fluorescence of borond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66f853153722ea56675b06ed63c85eae
https://doi.org/10.1039/c6tc05532j
https://doi.org/10.1039/c6tc05532j
Publikováno v:
ACS Chem Neurosci
Azobenzenes are the most widely studied photoswitches, and have become popular optical probes for biological systems. The cis configuration is normally metastable, meaning the trans configuration is always thermodynamically favored. The unique except
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e667ecb3193141ceb39b2c8444a2e9
https://europepmc.org/articles/PMC6657492/
https://europepmc.org/articles/PMC6657492/