Cell-type-directed design of synthetic enhancers.

Autor: Taskiran II; Laboratory of Computational Biology, VIB Center for AI & Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KULeuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Spanier KI; Laboratory of Computational Biology, VIB Center for AI & Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KULeuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Dickmänken H; Laboratory of Computational Biology, VIB Center for AI & Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KULeuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Kempynck N; Laboratory of Computational Biology, VIB Center for AI & Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KULeuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Pančíková A; Laboratory of Computational Biology, VIB Center for AI & Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KULeuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium.; VIB-KULeuven Center for Cancer Biology, Leuven, Belgium., Ekşi EC; Laboratory of Computational Biology, VIB Center for AI & Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KULeuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Hulselmans G; Laboratory of Computational Biology, VIB Center for AI & Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KULeuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Ismail JN; Laboratory of Computational Biology, VIB Center for AI & Computational Biology (VIB.AI), Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium.; UK Dementia Research Institute at Imperial College London, London, UK., Theunis K; Laboratory of Computational Biology, VIB Center for AI & Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KULeuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Vandepoel R; Laboratory of Computational Biology, VIB Center for AI & Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KULeuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Christiaens V; Laboratory of Computational Biology, VIB Center for AI & Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KULeuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Mauduit D; Laboratory of Computational Biology, VIB Center for AI & Computational Biology (VIB.AI), Leuven, Belgium.; VIB-KULeuven Center for Brain & Disease Research, Leuven, Belgium.; Department of Human Genetics, KU Leuven, Leuven, Belgium., Aerts S; Laboratory of Computational Biology, VIB Center for AI & Computational Biology (VIB.AI), Leuven, Belgium. stein.aerts@kuleuven.be.; VIB-KULeuven Center for Brain & Disease Research, Leuven, Belgium. stein.aerts@kuleuven.be.; Department of Human Genetics, KU Leuven, Leuven, Belgium. stein.aerts@kuleuven.be.

Publikováno v: Nature [Nature] 2024 Feb; Vol. 626 (7997), pp. 212-220. Date of Electronic Publication: 2023 Dec 12.