En processbeskrivning för utveckling av webbaserade system och gränssnitt : En fallstudie av utvecklingsprocesser på GMP-Systems AB

Autor: Ibrahim, Goran, Ek, Leonard

Affärssystem som inte har tydliga användargränssnitt tenderar att göra användarvänligheten sämre, vilket i sin tur kan leda till att delar av systemet inte nyttjas effektivt. Det kan därför vara lämpligt att ha en specifik och tydlig proces

Externí odkaz: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-214995

Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity.

Autor: Leonard EK; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Tomala J; Institute of Biotechnology of the Academy of Sciences of the Czech Republic, Vestec, Czech Republic.; Department of Chemical & Biomolecular Engineering and., Gould JR; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Leff MI; Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA., Lin JX; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA., Li P; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA., Porter MJ; Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA., Johansen ER; Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA., Thompson L; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Cao SD; Department of Chemical & Biomolecular Engineering and., Hou S; Department of Plastic & Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Henclova T; Institute of Biotechnology of the Academy of Sciences of the Czech Republic, Vestec, Czech Republic., Huliciak M; Institute of Biotechnology of the Academy of Sciences of the Czech Republic, Vestec, Czech Republic.; Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA., Sargunas PR; Department of Chemical & Biomolecular Engineering and., Fabilane CS; Program in Molecular Biophysics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Vaněk O; Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic., Kovar M; Laboratory of Tumor Immunology, Institute of Microbiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic., Schneider B; Institute of Biotechnology of the Academy of Sciences of the Czech Republic, Vestec, Czech Republic., Raimondi G; Vascularized Composite Allotransplantation Laboratory, Department of Plastic and Reconstructive Surgery., Leonard WJ; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA., Spangler JB; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Chemical & Biomolecular Engineering and.; Translational Tissue Engineering Center.; Department of Oncology.; Bloomberg-Kimmel Institute for Cancer Immunotherapy.; Sidney Kimmel Comprehensive Cancer Center; and.; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Sep 24; Vol. 9 (18). Date of Electronic Publication: 2024 Sep 24.

Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity.

Autor: Leonard EK; Department of Biomedical Engineering, Johns Hopkins University School of Medicine; Baltimore, USA., Tomala J; Institute of Biotechnology of the Academy of Sciences of the Czech Republic; Vestec, Czech Republic., Gould JR; Department of Biomedical Engineering, Johns Hopkins University School of Medicine; Baltimore, USA., Leff MI; Department of Biology, Johns Hopkins University; Baltimore, USA., Lin JX; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health; Bethesda, USA., Li P; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health; Bethesda, USA., Porter MJ; Department of Chemistry, Johns Hopkins University; Baltimore, USA., Johansen ER; Department of Chemistry, Johns Hopkins University; Baltimore, USA., Thompson L; Department of Biomedical Engineering, Johns Hopkins University School of Medicine; Baltimore, USA., Cao SD; Department of Chemical & Biomolecular Engineering, Johns Hopkins University School of Engineering; Baltimore, USA., Henclova T; Institute of Biotechnology of the Academy of Sciences of the Czech Republic; Vestec, Czech Republic., Huliciak M; Institute of Biotechnology of the Academy of Sciences of the Czech Republic; Vestec, Czech Republic., Vaněk O; Department of Biochemistry, Faculty of Science, Charles University; Prague, Czech Republic., Kovar M; Laboratory of Tumor Immunology, Institute of Microbiology of the Academy of Sciences of the Czech Republic; Prague, Czech Republic., Leonard WJ; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health; Bethesda, USA., Spangler JB; Department of Biomedical Engineering, Johns Hopkins University School of Medicine; Baltimore, USA.; Department of Chemical & Biomolecular Engineering, Johns Hopkins University School of Engineering; Baltimore, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, USA.; Department of Oncology, Johns Hopkins University School of Medicine; Baltimore, USA.; Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine; Baltimore, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; Baltimore, USA.; Department of Ophthalmology, Johns Hopkins University School of Medicine; Baltimore, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 May 04. Date of Electronic Publication: 2023 May 04.

Nanoparticle-based modulation of CD4 ⁺ T cell effector and helper functions enhances adoptive immunotherapy.

Autor: Isser A; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Silver AB; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21287, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Pruitt HC; Department of Chemical and Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Institute for NanoBioTechnology, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA., Mass M; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Elias EH; Department of Biology, Johns Hopkins University Krieger School of Arts and Sciences, Baltimore, MD, 21287, USA., Aihara G; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Kang SS; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Bachmann N; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Chen YY; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Leonard EK; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Bieler JG; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Chaisawangwong W; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Choy J; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Institute for NanoBioTechnology, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Department of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA., Shannon SR; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Gerecht S; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Institute for NanoBioTechnology, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Department of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Weber JS; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, 10016, USA., Spangler JB; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Department of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Schneck JP; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. jschnec1@jhmi.edu.; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. jschnec1@jhmi.edu.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. jschnec1@jhmi.edu.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. jschnec1@jhmi.edu.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. jschnec1@jhmi.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 14; Vol. 13 (1), pp. 6086. Date of Electronic Publication: 2022 Oct 14.

IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function.

Autor: Casciola-Rosen L; Department of Medicine, Division of Rheumatology., Thiemann DR; Department of Medicine, Division of Cardiology; and., Andrade F; Department of Medicine, Division of Rheumatology., Trejo-Zambrano MI; Department of Medicine, Division of Rheumatology., Leonard EK; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Spangler JB; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA.; Translational Tissue Engineering Center., Skinner NE; Department of Medicine, Division of Infectious Diseases; and., Bailey J; Department of Medicine, Division of Infectious Diseases; and., Yegnasubramanian S; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Wang R; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Vaghasia AM; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Gupta A; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Cox AL; Department of Medicine, Division of Infectious Diseases; and., Ray SC; Department of Medicine, Division of Infectious Diseases; and., Linville RM; Institute for NanoBioTechnology and.; Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Guo Z; Institute for NanoBioTechnology and., Searson PC; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Institute for NanoBioTechnology and.; Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Machamer CE; Department of Cell Biology and., Desiderio S; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Sauer LM; Adult Emergency Department, Johns Hopkins Hospital, Baltimore, Maryland, USA.; Johns Hopkins Biocontainment Unit, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Laeyendecker O; Department of Medicine, Division of Infectious Diseases; and.; Division of Intramural Medicine, National Institute of Allergy and Infectious Diseases, NIH, Baltimore, Maryland, USA., Garibaldi BT; Johns Hopkins Biocontainment Unit, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Medicine, Division of Pulmonary and Critical Care Medicine., Gao L; Department of Medicine, Division of Allergy and Clinical Immunology; and., Damarla M; Department of Medicine, Division of Pulmonary and Critical Care Medicine., Hassoun PM; Department of Medicine, Division of Pulmonary and Critical Care Medicine., Hooper JE; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Mecoli CA; Department of Medicine, Division of Rheumatology., Christopher-Stine L; Department of Medicine, Division of Rheumatology., Gutierrez-Alamillo L; Department of Medicine, Division of Rheumatology., Yang Q; Department of Medicine, Division of Rheumatology., Hines D; Department of Medicine, Division of Rheumatology., Clarke WA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Rothman RE; Adult Emergency Department, Johns Hopkins Hospital, Baltimore, Maryland, USA., Pekosz A; Department of Environmental Health and Engineering.; Department of Molecular Microbiology and Immunology, and., Fenstermacher KZ; Department of Environmental Health and Engineering., Wang Z; Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Zeger SL; Department of Medicine, Division of Rheumatology.; Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Rosen A; Department of Medicine, Division of Rheumatology.; Department of Cell Biology and.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Publikováno v: JCI insight [JCI Insight] 2022 May 09; Vol. 7 (9). Date of Electronic Publication: 2022 May 09.