Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ejvind Mørtz"'
Autor:
Thomas Kofoed, Rikke Raaen Lund, Martin Rask Johansen, Lars Skriver, Thomas K. Jorgensen, Katrine Pilely, Ejvind Mørtz
Publikováno v:
Analytical and Bioanalytical Chemistry
During biologics development, manufacturers must demonstrate clearance of host cell impurities and contaminants to ensure drug purity, manufacturing process consistency, and patient safety. Host cell proteins (HCPs) are a major class of process-relat
Autor:
Esben Eller, Carsten Bindslev-Jensen, Torben Barington, Ejvind Mørtz, Ulrik Sprogøe, Charlotte G. Mortz, Anja Pahlow Mose, Per Stahl Skov
Publikováno v:
Mose, A P, Mortz, E, Skov, P S, Mortz, C G, Eller, E, Sprogøe, U, Barington, T & Bindslev-Jensen, C 2020, ' The quest for ingested peanut protein in human serum ', Allergy, vol. 75, no. 7, pp. 1721-1729 . https://doi.org/10.1111/all.14109
Background: There is mounting evidence that systemic uptake of food allergens is key to triggering anaphylaxis. However, direct proof for this theory is still lacking. The purpose of this study was to quantify the absorption and to determine the abso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbee3c627b94219f12e8796af115dd7b
https://findresearcher.sdu.dk:8443/ws/files/170285867/all.14109.pdf
https://findresearcher.sdu.dk:8443/ws/files/170285867/all.14109.pdf
Autor:
Solveig Beck Nielsen, Katrine Pilely, Søren Hansen, Lars Skriver, Anette Draborg, Ejvind Mørtz, Rikke Raaen Lund, Maiken Lumby Henriksen
Publikováno v:
Pilely, K, Nielsen, S B, Draborg, A, Henriksen, M L, Hansen, S W K, Skriver, L, Mørtz, E & Lund, R R 2020, ' A novel approach to evaluate ELISA antibody coverage of host cell proteins—combining ELISA-based immunocapture and mass spectrometry ', Biotechnology Progress, vol. 36, no. 4, e2983 . https://doi.org/10.1002/btpr.2983
Biotechnology Progress
Biotechnology Progress
Monitoring host cell proteins (HCPs) is one of the most important analytical requirements in production of recombinant biopharmaceuticals to ensure product purity and patient safety. Enzyme‐linked immunosorbent assay (ELISA) is the standard method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db15fccb554b96e089f28f16676ef3b0
https://findresearcher.sdu.dk:8443/ws/files/170678160/btpr.2983.pdf
https://findresearcher.sdu.dk:8443/ws/files/170678160/btpr.2983.pdf
Autor:
Solveig Beck Nielsen, Rikke Raaen Lund, Søren Hansen, Anette Draborg, Lars Skriver, Maiken Lumby Henriksen, Ejvind Mørtz, Katrine Pilely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e3bc89b029468c2b604841f35a1d8e0
https://doi.org/10.1002/btpr.2983/v2/response1
https://doi.org/10.1002/btpr.2983/v2/response1
Publikováno v:
Maibom-Thomsen, S, Heissel, S, Mørtz, E, Højrup, P & Bunkenborg, J 2018, ' Discrimination of Isoleucine and Leucine by Dimethylation-Assisted MS3 ', Analytical Chemistry, vol. 90, no. 15, pp. 9055–9059 . https://doi.org/10.1021/acs.analchem.8b01375
Protein sequencing by mass spectrometry has transformed the field of biopharmaceutical analysis, but a missing part in the analytical toolkit is the ability to distinguish between the isomeric residues isoleucine and leucine because it is a requisite
Autor:
Marie Grimstrup, Ejvind Mørtz, Jakob Bunkenborg, Peter Højrup, Anne Fich Holmbjerg, Max Per Kristiansen, Thomas Kofoed, Søren Heissel
Publikováno v:
Heissel, S, Bunkenborg, J, Kristiansen, M P, Holmbjerg, A F, Grimstrup, M, Mørtz, E, Kofoed, T & Højrup, P 2018, ' Evaluation of spectral libraries and sample preparation for DIA-LC-MS analysis of host cell proteins : A case study of a bacterially expressed recombinant biopharmaceutical protein ', Protein Expression and Purification, vol. 147, pp. 69-77 . https://doi.org/10.1016/j.pep.2018.03.002
Recombinantly expressed biopharmaceutical proteins often undergo a series of purification steps with the aim of removing contaminating material. Depending on the application of the protein, there are various requirements for the degree of purity, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f4e5aabbe1c1f01713fe9c84375def
https://findresearcher.sdu.dk:8443/ws/files/152803723/Open_Access_Version.pdf
https://findresearcher.sdu.dk:8443/ws/files/152803723/Open_Access_Version.pdf
Autor:
Simina Vintila, Ejvind Mørtz, Herwig Schüler, Maja Brus, Pierre-Henri Clergeot, Sophia K. Ekengren
Publikováno v:
Phytopathology®. 102:878-891
Clergeot, P.-H., Schuler, H., Mortz, E., Brus, M., Vintila, S., and Ekengren, S. 2012. The corky root rot pathogen Pyrenochaeta lycopersici secretes a proteinaceous inducer of cell death affecting host plants differentially. Phytopathology 102:878-89
Publikováno v:
PROTEOMICS. 9:1230-1240
Members of the transforming growth factor (TGF)-beta superfamily are key regulators of lung development and homeostasis, in particular by controlling alveolar/bronchial epithelial cell function. TGF-beta signaling involves ligand-dependent activation
Autor:
Hinrich W. H. Göhlmann, John D. McKinney, Dirk Bald, Neeraj Dhar, Ejvind Mørtz, Luc Vranckx, Jean-Marc Neefs, Melanie Schulz, Koen Andries, Emre Özdemir, Ping Lu, Anil Koul
Publikováno v:
Nature Communications, 5:3369. Nature Publishing Group
Nature Communications
Europe PubMed Central
Koul, A, Vranckx, L, Dhar, N, Gohlmann, H W H, Ozdemir, E, Neefs, J M, Schulz, M, Lu, P, Mortz, E, McKinney, J D, Andries, K & Bald, D 2014, ' Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism ', Nature Communications, vol. 5, 3369, pp. 10 . https://doi.org/10.1038/ncomms4369
Koul, A, Vranckx, L, Dhar, N, Göhlmann, H, Özdemir, E, Neefs, J-M, Schulz, M, Lu, P, Mortz, E, McKinney, J D, Andries, K & Bald, D 2014, ' Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism ', Nature Communications, vol. 5, 3369 . https://doi.org/10.1038/ncomms4369
Nature Communications
Europe PubMed Central
Koul, A, Vranckx, L, Dhar, N, Gohlmann, H W H, Ozdemir, E, Neefs, J M, Schulz, M, Lu, P, Mortz, E, McKinney, J D, Andries, K & Bald, D 2014, ' Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism ', Nature Communications, vol. 5, 3369, pp. 10 . https://doi.org/10.1038/ncomms4369
Koul, A, Vranckx, L, Dhar, N, Göhlmann, H, Özdemir, E, Neefs, J-M, Schulz, M, Lu, P, Mortz, E, McKinney, J D, Andries, K & Bald, D 2014, ' Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism ', Nature Communications, vol. 5, 3369 . https://doi.org/10.1038/ncomms4369
Bedaquiline (BDQ), an ATP synthase inhibitor, is the first drug to be approved for treatment of multidrug-resistant tuberculosis in decades. Though BDQ has shown excellent efficacy in clinical trials, its early bactericidal activity during the first
Publikováno v:
Europe PubMed Central
In proteomics it is essential to be able to detect proteins separated by gel electrophoresis at high sensitivity. Silver staining is currently the most popular method. Here we present silver staining protocols that are optimized for staining sensitiv