Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Autor: Ej, Saunders, Dadaev T, Daniel Leongamornlert, Aa, Al Olama, Benlloch S, Gg, Giles, Wiklund F, Gronberg H, Ca, Haiman, Schleutker J, Bg, Nordestgaard, Rc, Travis, Neal D, Pasayan N, Kt, Khaw, Jl, Stanford, Wj, Blot, Sn, Thibodeau, Maier C, As, Kibel

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2a6d46ff550c59b3f6993a3182bebd0a
http://europepmc.org/abstract/med/26964030

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.

Autor: Wang A; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Shen J; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Rodriguez AA; Argonne National Laboratory, Lemont, IL, USA., Saunders EJ; The Institute of Cancer Research, London, UK., Chen F; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Janivara R; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA., Darst BF; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Sheng X; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Xu Y; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Chou AJ; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Benlloch S; Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK., Dadaev T; The Institute of Cancer Research, London, UK., Brook MN; The Institute of Cancer Research, London, UK., Plym A; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.; Urology Division, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sahimi A; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Hoffman TJ; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, CA, USA., Takahashi A; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Genomic Medicine, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan., Matsuda K; Department of Computational Biology and Medical Sciences, Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Momozawa Y; Laboratory for Genotyping Development, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan., Fujita M; Laboratory for Cancer Genomics, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan., Laisk T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Figuerêdo J; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Muir K; Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Warwick Medical School, University of Warwick, Coventry, UK., Ito S; Department of Orthopaedics, Shimane University, Izumo, Japan.; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Liu X; Laboratory for Statistical and Translational Genetics, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan., Uchio Y; Department of Orthopaedics, Shimane University, Izumo, Japan., Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kamatani Y; Laboratory for Statistical and Translational Genetics, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Lophatananon A; Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Wan P; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Andrews C; Harvard TH Chan School of Public Health and Division of Population Sciences, Dana Farber Cancer Institute, Boston, MA, USA., Lori A; Department of Population Science, American Cancer Society, Kennesaw, GA, USA., Choudhury PP; Surveillance & Health Science Department, American Cancer Society, Kennesaw, GA, USA., Schleutker J; Institute of Biomedicine, University of Turku, Turku, Finland.; Department of Medical Genetics, Genomics, Laboratory Division, Turku University Hospital, Turku, Finland., Tammela TLJ; Department of Urology, Tampere University Hospital, Tampere, Finland., Sipeky C; Institute of Biomedicine, University of Turku, Turku, Finland., Auvinen A; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland., Giles GG; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia., Southey MC; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia., MacInnis RJ; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Cybulski C; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Wokolorczyk D; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Lubinski J; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Rentsch CT; Yale School of Medicine, New Haven, CT, USA.; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.; VA Connecticut Healthcare System, West Haven, CT, USA., Cho K; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; VA Boston Healthcare System, Boston, MA, USA., Mcmahon BH; Theoretical Biology Division, Los Alamos National Lab, Los Alamos, NM, USA., Neal DE; Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Headington, UK.; University of Cambridge, Department of Oncology, Addenbrooke's Hospital, Cambridge, UK.; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK., Donovan JL; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Hamdy FC; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.; Faculty of Medical Science, University of Oxford, John Radcliffe Hospital, Oxford, UK., Martin RM; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, UK.; Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Nordestgaard BG; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Nielsen SF; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Weischer M; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Bojesen SE; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Røder A; Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Stroomberg HV; Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Batra J; Centre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, Queensland, Australia.; Translational Research Institute, Brisbane, Queensland, Australia., Chambers S; University of Technology, Sydney, New South Wales, Australia., Horvath L; Chris O'Brien Lifehouse, Camperdown, Sydney, New South Wales, Australia.; Garvan Institute of Medical Research, Sydney, New South Wales, Australia., Clements JA; Translational Research Institute, Brisbane, Queensland, Australia., Tilly W; Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide, Adelaide, South Australia, Australia., Risbridger GP; Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.; Prostate Cancer Translational Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Gronberg H; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden., Aly M; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Urology, Karolinska University Hospital, Stockholm, Sweden., Szulkin R; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.; SDS Life Sciences, Stockholm, Sweden., Eklund M; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden., Nordstrom T; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.; Department of Clinical Sciences at Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden., Pashayan N; Department of Applied Health Research, University College London, London, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, Strangeways Laboratory, University of Cambridge, Cambridge, UK., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, Strangeways Laboratory, University of Cambridge, Cambridge, UK., Ghoussaini M; Open Targets, Wellcome Sanger Institute, Saffron Walden, UK., Travis RC; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Key TJ; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Riboli E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Park JY; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA., Sellers TA; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA., Lin HY; School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Weinstein S; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Cook MB; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Mucci LA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Giovannucci E; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Lindstrom S; Department of Epidemiology, University of Washington, Seattle, WA, USA., Kraft P; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Hunter DJ; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Penney KL; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA., Turman C; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Tangen CM; SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Goodman PJ; SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Thompson IM Jr; CHRISTUS Santa Rosa Hospital-Medical Center, San Antonio, TX, USA., Hamilton RJ; Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.; Department of Surgery (Urology), University of Toronto, Toronto, Ontario, Canada., Fleshner NE; Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada., Finelli A; Division of Urology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada., Parent MÉ; Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Laval, Quebec, Canada., Stanford JL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Ostrander EA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Koutros S; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Beane Freeman LE; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Stampfer M; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA., Wolk A; Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Håkansson N; Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Andriole GL; Brady Urological Institute in National Capital Region, Johns Hopkins University, Baltimore, MD, USA., Hoover RN; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Machiela MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Sørensen KD; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Borre M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Urology, Aarhus University Hospital, Aarhus, Denmark., Blot WJ; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; International Epidemiology Institute, Rockville, MD, USA., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Yeboah ED; University of Ghana Medical School, Accra, Ghana., Mensah JE; University of Ghana Medical School, Accra, Ghana.; Korle Bu Teaching Hospital, Accra, Ghana., Lu YJ; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, London, UK., Zhang HW; Second Military Medical University, Shanghai, China., Feng N; Wuxi Second Hospital, Nanjing Medical University, Wuxi, China., Mao X; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, London, UK., Wu Y; Department of Urology, First Affiliated Hospital, The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China., Zhao SC; Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Sun Z; The People's Hospital of Liaoning Proviouce, The People's Hospital of China Medical University, Shenyang, China., Thibodeau SN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., McDonnell SK; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Schaid DJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., West CML; Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, UK., Barnett G; University of Cambridge Department of Oncology, Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Maier C; Humangenetik Tuebingen, Tuebingen, Germany., Schnoeller T; Department of Urology, University Hospital Ulm, Ulm, Germany., Luedeke M; Humangenetik Tuebingen, Tuebingen, Germany., Kibel AS; Division of Urologic Surgery, Brigham and Womens Hospital, Boston, MA, USA., Drake BF; Washington University School of Medicine, St. Louis, MO, USA., Cussenot O; GRC 5 Predictive Onco-Urology, Sorbonne Université, Paris, France.; CeRePP, Paris, France., Cancel-Tassin G; GRC 5 Predictive Onco-Urology, Sorbonne Université, Paris, France.; CeRePP, Paris, France., Menegaux F; Exposome and Heredity, CESP (UMR 1018), Paris-Saclay Medical School, Paris-Saclay University, Inserm, Gustave Roussy, Villejuif, France., Truong T; Exposome and Heredity, CESP (UMR 1018), Paris-Saclay Medical School, Paris-Saclay University, Inserm, Gustave Roussy, Villejuif, France., Koudou YA; Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France., John EM; Department of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Grindedal EM; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Maehle L; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Khaw KT; Clinical Gerontology Unit, University of Cambridge, Cambridge, UK., Ingles SA; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Stern MC; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Vega A; Fundación Pública Galega Medicina Xenómica, Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; Centro de Investigación en Red de Enfermedades Raras, Madrid, Spain., Gómez-Caamaño A; Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain., Fachal L; Fundación Pública Galega Medicina Xenómica, Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; Centro de Investigación en Red de Enfermedades Raras, Madrid, Spain.; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK., Rosenstein BS; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kerns SL; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA., Ostrer H; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA., Teixeira MR; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center, Porto, Portugal.; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center, Porto, Portugal.; School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal., Paulo P; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center, Porto, Portugal., Brandão A; Cancer Genetics Group, IPO Porto Research Center (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center, Porto, Portugal., Watya S; Uro Care, Kampala, Uganda., Lubwama A; Uro Care, Kampala, Uganda., Bensen JT; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Butler EN; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Mohler JL; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Taylor JA; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.; Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA., Kogevinas M; ISGlobal, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER Epidemiología y Salud Pública, Madrid, Spain., Dierssen-Sotos T; CIBER Epidemiología y Salud Pública, Madrid, Spain.; University of Cantabria-IDIVAL, Santander, Spain., Castaño-Vinyals G; ISGlobal, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER Epidemiología y Salud Pública, Madrid, Spain., Cannon-Albright L; Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA., Teerlink CC; Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA., Huff CD; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Pilie P; Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yu Y; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bohlender RJ; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gu J; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Strom SS; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Multigner L; Univ Rennes, Inserm, EHESP, Institut de recherche en santé, environnement et travail, Rennes, France., Blanchet P; CHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Institut de recherche en santé, environnement et travail, Pointe-à-Pitre, France., Brureau L; CHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Institut de recherche en santé, environnement et travail, Pointe-à-Pitre, France., Kaneva R; Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria., Slavov C; Department of Urology and Alexandrovska University Hospital, Medical University of Sofia, Sofia, Bulgaria., Mitev V; Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria., Leach RJ; Department of Cell Systems and Anatomy and Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Chen X; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Holleczek B; Saarland Cancer Registry, Saarbrücken, Germany., Schöttker B; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Klein EA; Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.; Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH, USA., Hsing AW; Department of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Kittles RA; City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Murphy AB; Department of Urology, Northwestern University, Chicago, IL, USA., Logothetis CJ; Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kim J; Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Neuhausen SL; Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Steele L; Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Ding YC; Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Isaacs WB; James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD, USA., Nemesure B; Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA., Hennis AJM; Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.; Chronic Disease Research Centre and Faculty of Medical Sciences, University of the West Indies, Bridgetown, Barbados., Carpten J; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Pandha H; The University of Surrey, Guildford, UK., Michael A; The University of Surrey, Guildford, UK., De Ruyck K; Ghent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences, Ghent, Belgium., De Meerleer G; Department of Radiotherapy, Ghent University Hospital, Ghent, Belgium., Ost P; Department of Radiotherapy, Ghent University Hospital, Ghent, Belgium., Xu J; Program for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA., Razack A; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Lim J; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Teo SH; Cancer Research Malaysia, Outpatient Centre, Subang Jaya Medical Centre, Subang Jaya, Malaysia., Newcomb LF; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Urology, University of Washington, Seattle, WA, USA., Lin DW; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Urology, University of Washington, Seattle, WA, USA., Fowke JH; Department of Preventive Medicine, Division of Epidemiology, The University of Tennessee Health Science Center, Memphis, TN, USA., Neslund-Dudas CM; Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA., Rybicki BA; Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA., Gamulin M; Division of Medical Oncology, Urogenital Unit, Department of Oncology, University Hospital Centre Zagreb, Zagreb, Croatia., Lessel D; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kulis T; Department of Urology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia., Usmani N; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.; Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada., Abraham A; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.; Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada., Singhal S; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada., Parliament M; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.; Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada., Claessens F; Department of Cellular and Molecular Medicine, Molecular Endocrinology Laboratory, Leuven, Belgium., Joniau S; Department of Urology, University Hospitals Leuven, Leuven, Belgium., Van den Broeck T; Department of Cellular and Molecular Medicine, Molecular Endocrinology Laboratory, Leuven, Belgium.; Department of Urology, University Hospitals Leuven, Leuven, Belgium., Gago-Dominguez M; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS, Santiago de Compostela, Spain.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Castelao JE; Genetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur, Vigo, Spain., Martinez ME; Moores Cancer Center, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA., Larkin S; Scientific Education Support, Thames Ditton, Surrey, Formerly Cancer Sciences, University of Southampton, Southampton, UK., Townsend PA; School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK., Aukim-Hastie C; Scientific Education Support, Thames Ditton, UK., Bush WS; Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA., Aldrich MC; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Crawford DC; Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA., Srivastava S; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington DC, USA., Cullen J; Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.; Department of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Petrovics G; Department of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Casey G; Department of Public Health Science, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Wang Y; Department of Population Science, American Cancer Society, Kennesaw, GA, USA., Tettey Y; Korle Bu Teaching Hospital, Accra, Ghana.; Department of Pathology, University of Ghana, Accra, Ghana., Lachance J; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA., Tang W; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Biritwum RB; Korle Bu Teaching Hospital, Accra, Ghana., Adjei AA; Department of Pathology, University of Ghana Medical School, Accra, Ghana., Tay E; Korle Bu Teaching Hospital, Accra, Ghana., Truelove A; Westat, Rockville, MD, USA., Niwa S; Westat, Rockville, MD, USA., Yamoah K; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.; Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA., Govindasami K; The Institute of Cancer Research, London, UK., Chokkalingam AP; School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Keaton JM; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Hellwege JN; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Nashville, TN, USA., Clark PE; Atrium Health/Levine Cancer Institute, Charlotte, NC, USA., Jalloh M; Hôpital Général Idrissa Pouye, Dakar, Senegal., Gueye SM; Hôpital Général Idrissa Pouye, Dakar, Senegal., Niang L; Hôpital Général Idrissa Pouye, Dakar, Senegal., Ogunbiyi O; Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Shittu O; Department of Surgery, College of Medicine, University of Ibadan and Univerity College Hospital, Ibadan, Nigeria., Amodu O; Institute of Child Health, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria., Adebiyi AO; Clinical Epidemiology Unit, Department of Community Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria., Aisuodionoe-Shadrach OI; College of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria., Ajibola HO; College of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria., Jamda MA; College of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria., Oluwole OP; College of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria., Nwegbu M; College of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria., Adusei B; 37 Military Hospital, Accra, Ghana., Mante S; 37 Military Hospital, Accra, Ghana., Darkwa-Abrahams A; Korle Bu Teaching Hospital, Accra, Ghana., Diop H; Laboratoires Bacteriologie et Virologie, Hôpital Aristide Le Dantec, Dakar, Senegal., Gundell SM; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Roobol MJ; Department of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands., Jenster G; Department of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands., van Schaik RHN; Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, the Netherlands., Hu JJ; The University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL, USA., Sanderson M; Department of Family and Community Medicine, Meharry Medical College, Nashville, TN, USA., Kachuri L; Department of Epidemiology and Population Health, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Varma R; Southern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, CA, USA., McKean-Cowdin R; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Torres M; Southern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, CA, USA., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zawistowski M; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Zöllner S; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Lu Z; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Van Den Eeden SK; Division of Research, Kaiser Permanente, Oakland, CA, USA., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK., Ambs S; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Edwards TL; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Rebbeck TR; Harvard TH Chan School of Public Health and Division of Population Sciences, Dana Farber Cancer Institute, Boston, MA, USA., Fritsche L; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Wiklund F; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden., Nakagawa H; Laboratory for Cancer Genomics, RIKEN Center of Integrative Medical Sciences, Yokohama, Japan., Witte JS; Department of Epidemiology and Population Health, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Gaziano JM; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; VA Boston Healthcare System, Boston, MA, USA., Justice AC; Yale School of Medicine, New Haven, CT, USA., Mancuso N; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Terao C; Laboratory for Statistical and Translational Genetics, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.; Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.; The Department of Applied Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan., Eeles RA; The Institute of Cancer Research, London, UK.; Royal Marsden NHS Foundation Trust, London, UK., Kote-Jarai Z; The Institute of Cancer Research, London, UK., Madduri RK; Argonne National Laboratory, Lemont, IL, USA., Conti DV; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Haiman CA; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. haiman@usc.edu.

Publikováno v: Nature genetics [Nat Genet] 2023 Dec; Vol. 55 (12), pp. 2065-2074. Date of Electronic Publication: 2023 Nov 09.

Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry.

Autor: Chen F; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Madduri RK; Argonne National Laboratory, Lemont, IL, USA., Rodriguez AA; Argonne National Laboratory, Lemont, IL, USA., Darst BF; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Chou A; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Sheng X; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Wang A; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Shen J; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Saunders EJ; The Institute of Cancer Research, London, UK., Rhie SK; Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Bensen JT; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ingles SA; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Kittles RA; Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Strom SS; Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Rybicki BA; Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA., Nemesure B; Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA., Isaacs WB; James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD, USA., Stanford JL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Sanderson M; Department of Family and Community Medicine, Meharry Medical College, Nashville, TN, USA., John EM; Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Park JY; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA., Xu J; Program for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA., Wang Y; Department of Population Science, American Cancer Society, Kennesaw, GA, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Huff CD; Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Yeboah ED; University of Ghana Medical School, Accra, Ghana., Tettey Y; Department of Pathology, University of Ghana, Accra, Ghana; Korle Bu Teaching Hospital, Accra, Ghana., Lachance J; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA., Tang W; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Rentsch CT; Yale School of Medicine, New Haven, CT, USA; VA Connecticut Healthcare System, West Haven, CT, USA; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK., Cho K; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; VA Boston Healthcare System, Jamaica Plain, MA, USA., Mcmahon BH; Theoretical Biology Division, Los Alamos National Lab, Los Alamos, NM, USA., Biritwum RB; Korle Bu Teaching Hospital, Accra, Ghana., Adjei AA; Department of Pathology, University of Ghana Medical School, Accra, Ghana., Tay E; Korle Bu Teaching Hospital, Accra, Ghana., Truelove A; Westat, Rockville, MD, USA., Niwa S; Westat, Rockville, MD, USA., Sellers TA; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA., Yamoah K; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA; Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA., Murphy AB; Department of Urology, Northwestern University, Chicago, IL, USA., Crawford DC; Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA., Patel AV; Department of Population Science, American Cancer Society, Kennesaw, GA, USA., Bush WS; Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA., Aldrich MC; Division of Epidemiology, Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Cussenot O; Department of Urology and Predictive Onco-Urology Group, Sorbonne Université, GRC 5 Predictive Onco-Urology, APHP-Sorbonne Université, Paris, France; CeRePP, Tenon Hospital, Paris, France., Petrovics G; Department of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Cullen J; Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA; Department of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Neslund-Dudas CM; Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA., Stern MC; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Kote-Jarai Z; The Institute of Cancer Research, London, UK., Govindasami K; The Institute of Cancer Research, London, UK., Cook MB; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Chokkalingam AP; School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Hsing AW; Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Goodman PJ; SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hoffmann TJ; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA., Drake BF; Division of Public Health Sciences, Washington University School of Medicine, St. Louis, MO, USA., Hu JJ; The University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL, USA., Keaton JM; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Hellwege JN; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Nashville, TN, USA., Clark PE; Atrium Health/Levine Cancer Institute, Charlotte, NC, USA., Jalloh M; Hôpital Général Idrissa Pouye, Dakar, Senegal., Gueye SM; Hôpital Général Idrissa Pouye, Dakar, Senegal., Niang L; Hôpital Général Idrissa Pouye, Dakar, Senegal., Ogunbiyi O; College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria., Idowu MO; College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria., Popoola O; College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria., Adebiyi AO; College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria., Aisuodionoe-Shadrach OI; College of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria., Ajibola HO; College of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria., Jamda MA; College of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria., Oluwole OP; College of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria., Nwegbu M; College of Health Sciences, University of Abuja, University of Abuja Teaching Hospital and Cancer Science Center, Abuja, Nigeria., Adusei B; 37 Military Hospital, Accra, Ghana., Mante S; 37 Military Hospital, Accra, Ghana., Darkwa-Abrahams A; Korle Bu Teaching Hospital, Accra, Ghana., Mensah JE; Korle Bu Teaching Hospital, Accra, Ghana., Diop H; Laboratoires Bacteriologie et Virologie, Hôpital Aristide Le Dantec, Dakar, Senegal., Van Den Eeden SK; Division of Research, Kaiser Permanente, Northern California, Oakland, CA, USA; Department of Urology, University of California, San Francisco, San Francisco, CA, USA., Blanchet P; CHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Pointe-à-Pitre, Guadeloupe, France., Fowke JH; Department of Preventive Medicine, Division of Epidemiology, The University of Tennessee Health Science Center, Memphis, TN, USA., Casey G; Department of Public Health Science, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Hennis AJ; Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA., Lubwama A; Uro Care, Kampala, Uganda., Thompson IM Jr; CHRISTUS Santa Rosa Medical Center Hospital, San Antonio, TX, USA., Leach R; Department of Urology, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Easton DF; Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Loos RJ; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gundell SM; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Wan P; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Mohler JL; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA., Fontham ET; School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Smith GJ; Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA., Taylor JA; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA., Srivastava S; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, USA., Eeles RA; The Institute of Cancer Research, London, UK; Royal Marsden NHS Foundation Trust, London, UK., Carpten JD; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Kibel AS; Department of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Multigner L; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Rennes, France., Parent MÉ; Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Laval, QC, Canada., Menegaux F; Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif Cédex, France; Paris-Sud University, Villejuif Cédex, France., Cancel-Tassin G; Department of Urology and Predictive Onco-Urology Group, Sorbonne Université, GRC 5 Predictive Onco-Urology, APHP-Sorbonne Université, Paris, France; CeRePP, Tenon Hospital, Paris, France., Klein EA; Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA., Andrews C; Harvard TH Chan School of Public Health and Division of Population Sciences, Dana Farber Cancer Institute, Boston, MA, USA; Glickman Urological & Kidney Institute, Cleveland, OH, USA., Rebbeck TR; Harvard TH Chan School of Public Health and Division of Population Sciences, Dana Farber Cancer Institute, Boston, MA, USA., Brureau L; CHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Pointe-à-Pitre, Guadeloupe, France., Ambs S; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Edwards TL; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Watya S; Uro Care, Kampala, Uganda., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Witte JS; Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA; Stanford Cancer Institute, Stanford University, Stanford, CA, USA., Blot WJ; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; International Epidemiology Institute, Rockville, MD, USA., Michael Gaziano J; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA., Justice AC; Yale School of Medicine, New Haven, CT, USA; VA Connecticut Healthcare System, West Haven, CT, USA., Conti DV; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Haiman CA; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: haiman@usc.edu.

Publikováno v: European urology [Eur Urol] 2023 Jul; Vol. 84 (1), pp. 13-21. Date of Electronic Publication: 2023 Mar 03.

Prostate cancer risk in men of differing genetic ancestry and approaches to disease screening and management in these groups.

Autor: McHugh J; The Institute of Cancer Research, London, UK. jana.mchugh@icr.ac.uk.; The Royal Marsden NHS Foundation Trust, London, UK. jana.mchugh@icr.ac.uk.; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG, UK. jana.mchugh@icr.ac.uk., Saunders EJ; The Institute of Cancer Research, London, UK., Dadaev T; The Institute of Cancer Research, London, UK., McGrowder E; The Institute of Cancer Research, London, UK., Bancroft E; The Institute of Cancer Research, London, UK.; The Royal Marsden NHS Foundation Trust, London, UK., Kote-Jarai Z; The Institute of Cancer Research, London, UK., Eeles R; The Institute of Cancer Research, London, UK.; The Royal Marsden NHS Foundation Trust, London, UK.

Publikováno v: British journal of cancer [Br J Cancer] 2022 Jun; Vol. 126 (10), pp. 1366-1373. Date of Electronic Publication: 2021 Dec 18.

Rare Germline Variants in ATM Predispose to Prostate Cancer: A PRACTICAL Consortium Study.

Autor: Karlsson Q; Division of Genetics & Epidemiology, The Institute of Cancer Research, London, UK., Brook MN; Division of Genetics & Epidemiology, The Institute of Cancer Research, London, UK., Dadaev T; Division of Genetics & Epidemiology, The Institute of Cancer Research, London, UK., Wakerell S; Division of Genetics & Epidemiology, The Institute of Cancer Research, London, UK., Saunders EJ; Division of Genetics & Epidemiology, The Institute of Cancer Research, London, UK., Muir K; Division of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester, UK; Warwick Medical School, University of Warwick, Coventry, UK., Neal DE; Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK; Department of Oncology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK., Giles GG; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia., MacInnis RJ; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia., Thibodeau SN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., McDonnell SK; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA., Cannon-Albright L; Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA; George E Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA., Teixeira MR; Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal; Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal; Cancer Genetics Group, IPO-Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal., Paulo P; Cancer Genetics Group, IPO-Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal., Cardoso M; Cancer Genetics Group, IPO-Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal., Huff C; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Li D; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yao Y; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Scheet P; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Permuth JB; Departments of Cancer Epidemiology and Gastrointestinal Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Stanford JL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA., Dai JY; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Ostrander EA; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA., Cussenot O; GRC n°, AP-HP, Tenon Hospital, Sorbonne Universite, Paris, France; CeRePP, Tenon Hospital, Paris, France., Cancel-Tassin G; GRC n°, AP-HP, Tenon Hospital, Sorbonne Universite, Paris, France; CeRePP, Tenon Hospital, Paris, France., Hoegel J; Institute for Human Genetics, University Hospital Ulm, Ulm, Germany., Herkommer K; Department of Urology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Schleutker J; Institute of Biomedicine, University of Turku, Turku, Finland; Department of Medical Genetics, Genomics, Laboratory Division, Turku University Hospital, Turku, Finland., Tammela TLJ; Department of Urology, Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Rathinakannan V; Institute of Biomedicine, University of Turku, Turku, Finland., Sipeky C; Institute of Biomedicine, University of Turku, Turku, Finland., Wiklund F; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden., Grönberg H; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden., Aly M; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, Solna, Stockholm, Sweden; Department of Urology, Karolinska University Hospital, Solna, Stockholm., Isaacs WB; James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD, USA., Dickinson JL; University of Tasmania, Menzies Institute for Medical Research, Hobart, Tasmania, Australia., FitzGerald LM; University of Tasmania, Menzies Institute for Medical Research, Hobart, Tasmania, Australia., Chua MLK; Divisions of Radiation Oncology and Medical Sciences, National Cancer Centre Singapore, Singapore; Duke-NUS Medical School, Singapore., Nguyen-Dumont T; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia; Department of Clinical Pathology, The Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia., Schaid DJ; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA., Southey MC; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia; Department of Clinical Pathology, The Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia., Eeles RA; Division of Genetics & Epidemiology, The Institute of Cancer Research, London, UK; Royal Marsden NHS Foundation Trust, London, UK., Kote-Jarai Z; Division of Genetics & Epidemiology, The Institute of Cancer Research, London, UK. Electronic address: zsofia.kote-jarai@icr.ac.uk.

Publikováno v: European urology oncology [Eur Urol Oncol] 2021 Aug; Vol. 4 (4), pp. 570-579. Date of Electronic Publication: 2021 Jan 09.