CD69 expression discriminates MHC-dependent and -independent stages of thymocyte positive selection

Autor: Katherine Hare, Ej, Jenkinson, Anderson G

Publikováno v: Europe PubMed Central

In the thymus, phenotypically and functionally mature single positive cells are generated from immature CD4+8+ precursors by a process known as positive selection. Although this event is known to involve alphabetaTCR ligation by peptide/MHC complexes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::33c5d62699afc507b1d26b14a6d36cf9
https://pubmed.ncbi.nlm.nih.gov/10201918

Intracellular signaling pathways involved in the induction of apoptosis in immature thymic T lymphocytes

Autor: Kl, Anderson, Anderson G, Robert H Michell, Ej, Jenkinson, Jj, Owen

Publikováno v: Europe PubMed Central

We describe a novel technique for studying the signaling pathways that control thymocyte negative selection which maintains the essential interactions between thymocytes and thymic stromal cells. Bisected lobes from newborn mouse thymus are maintaine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::80fd35841518880288b22bb6229d2ff1
https://pubmed.ncbi.nlm.nih.gov/8666773

Inositol lipids and phosphates in the proliferation and differentiation of lymphocytes and myeloid cells

Autor: Robert H Michell, La, Conroy, Finney M, Pj, French, Cm, Bunce, Anderson K, Ma, Baxter, Brown G, Gordon J, Ej, Jenkinson

Publikováno v: Europe PubMed Central

It is established that receptor-stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate is an essential signalling reaction in the responses of many haemopoietic cells to stimuli: examples include platelet activation, antigen-driven initiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4cc2e86e0c0ddd74755906f90fafa8fc
https://pubmed.ncbi.nlm.nih.gov/1327680

Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus.

Autor: Cowan JE; Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom;, McCarthy NI; Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom;, Parnell SM; Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom;, White AJ; Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom;, Bacon A; Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom;, Serge A; Centre de Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, INSERM Unité Mixte de Recherche 1068, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7258, Aix-Marseille University, UM 105, F-13009 Marseille, France; and., Irla M; Centre d'Immunologie de Marseille-Luminy, INSERM Unité Mixte de Recherche 631, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6102, Aix-Marseille University, UM 2, F-13009 Marseille, France., Lane PJ; Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom;, Jenkinson EJ; Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom;, Jenkinson WE; Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom;, Anderson G; Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom; g.anderson@bham.ac.uk.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Aug 01; Vol. 193 (3), pp. 1204-12. Date of Electronic Publication: 2014 Jul 02.

Mechanisms of thymus medulla development and function.

Autor: Anderson G; MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK, g.anderson@bham.ac.uk., Baik S, Cowan JE, Holland AM, McCarthy NI, Nakamura K, Parnell SM, White AJ, Lane PJ, Jenkinson EJ, Jenkinson WE

Publikováno v: Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 2014; Vol. 373, pp. 19-47.