Mature reverse transcriptase (p66/p51) is responsible for low levels of viral DNA found in human immunodeficiency virus type 1 (HIV-1)

Autor: Ej, Arts, johnson mak, Kleiman L, Ma, Wainberg

Publikováno v: Europe PubMed Central

Reverse transcription of the HIV RNA genome is thought to occur in the host cell cytoplasm after viral adsorption. However, viral DNA has been isolated in cell-free virus particles. We have quantitated by polymerase chain reaction (PCR) amplification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d6dc274232c301057c6f47c7bfe7893a
https://pubmed.ncbi.nlm.nih.gov/7512179

Effective and targeted latency reversal in CD4 ⁺ T cells from individuals on long term combined antiretroviral therapy initiated during chronic HIV-1 infection.

Autor: Ngo MH; Department of Microbiology and Immunology, University of Western Ontario, London, Canada.; College of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi, Vietnam., Pankrac J; Department of Microbiology and Immunology, University of Western Ontario, London, Canada., Ho RCY; Department of Microbiology and Immunology, University of Western Ontario, London, Canada., Ndashimye E; Department of Microbiology and Immunology, University of Western Ontario, London, Canada., Pawa R; Department of Microbiology and Immunology, University of Western Ontario, London, Canada., Ceccacci R; Department of Microbiology and Immunology, University of Western Ontario, London, Canada., Biru T; Department of Microbiology and Immunology, University of Western Ontario, London, Canada.; Special Immunology Unit and Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA., Olabode AS; Department of Microbiology and Immunology, University of Western Ontario, London, Canada., Klein K; Department of Microbiology and Immunology, University of Western Ontario, London, Canada.; Bristol Veterinary School, University of Bristol, Bristol, UK., Li Y; Department of Microbiology and Immunology, University of Western Ontario, London, Canada., Kovacs C; Maple Leaf Medical Clinic and Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Canada., Assad R; Special Immunology Unit and Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA., Jacobson JM; Special Immunology Unit and Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA., Canaday DH; Special Immunology Unit and Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA., Tomusange S; Rakai Health Sciences Program, Kalisizo, Uganda., Jamiru S; Rakai Health Sciences Program, Kalisizo, Uganda., Anok A; Rakai Health Sciences Program, Kalisizo, Uganda., Kityamuweesi T; Rakai Health Sciences Program, Kalisizo, Uganda., Buule P; Rakai Health Sciences Program, Kalisizo, Uganda., Galiwango RM; Rakai Health Sciences Program, Kalisizo, Uganda., Reynolds SJ; Rakai Health Sciences Program, Kalisizo, Uganda.; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Quinn TC; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Redd AD; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Prodger JL; Department of Microbiology and Immunology, University of Western Ontario, London, Canada., Mann JFS; Department of Microbiology and Immunology, University of Western Ontario, London, Canada.; Bristol Veterinary School, University of Bristol, Bristol, UK., Arts EJ; Department of Microbiology and Immunology, University of Western Ontario, London, Canada.

Publikováno v: Emerging microbes & infections [Emerg Microbes Infect] 2024 Dec; Vol. 13 (1), pp. 2327371. Date of Electronic Publication: 2024 Mar 26.

Real-time evaluation of signal accuracy in wastewater surveillance of pathogens with high rates of mutation.

Autor: Thakali O; Department of Civil Engineering, University of Ottawa, Ottawa, ON, K1N 6N5, Canada., Mercier É; Department of Civil Engineering, University of Ottawa, Ottawa, ON, K1N 6N5, Canada., Eid W; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, K1H 8L1, Canada., Wellman M; The Ottawa Hospital Research Institute, 1053 Carling Ave, Ottawa, ON, K1Y 4E9, Canada., Brasset-Gorny J; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, K1H 8L1, Canada., Overton AK; Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada., Knapp JJ; Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada., Manuel D; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, K1H 8L1, Canada.; Department of Family Medicine, University of Ottawa, 75 Laurier Ave. E, Ottawa, ON, K1N 6N5, Canada.; School of Epidemiology and Public Health, University of Ottawa, 75 Laurier Ave. E, Ottawa, ON, K1N 6N5, Canada., Charles TC; Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada., Goodridge L; Department of Food Science, Canadian Research Institute for Food Safety, University of Guelph, Guelph, ON, N1G 2W1, Canada., Arts EJ; Department of Microbiology and Immunology, Western University, London, ON, N6A 3K7, Canada., Poon AFY; Department of Microbiology and Immunology, Western University, London, ON, N6A 3K7, Canada., Brown RS; School of Environmental Studies and Department of Chemistry, Queen's University, Kingston, ON, Canada., Graber TE; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, K1H 8L1, Canada., Delatolla R; Department of Civil Engineering, University of Ottawa, Ottawa, ON, K1N 6N5, Canada., DeGroot CT; Department of Mechanical and Materials Engineering, Western University, London, ON, N6A 5B9, Canada. christopher.degroot@uwo.ca.

Publikováno v: Scientific reports [Sci Rep] 2024 Feb 14; Vol. 14 (1), pp. 3728. Date of Electronic Publication: 2024 Feb 14.

Optimal Expression, Function, and Immunogenicity of an HIV-1 Vaccine Derived from the Approved Ebola Vaccine, rVSV-ZEBOV.

Autor: Azizi H; Département de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.; Human Health Therapeutics, National Research Council Canada, Ottawa, ON K1N 5A2, Canada., Knapp JP; Department of Microbiology and Immunology, Western University, London, ON N6A 3K7, Canada., Li Y; Department of Microbiology and Immunology, Western University, London, ON N6A 3K7, Canada., Berger A; Département de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada., Lafrance MA; Département de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada., Pedersen J; Département de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada., de la Vega MA; Département de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.; Galveston National Laboratory, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA., Racine T; Département de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.; Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada., Kang CY; Department of Microbiology and Immunology, Western University, London, ON N6A 3K7, Canada., Mann JFS; Bristol Veterinary School, University of Bristol, Langford House, Langford, BS40 5DU Bristol, UK., Dikeakos JD; Department of Microbiology and Immunology, Western University, London, ON N6A 3K7, Canada., Kobinger G; Galveston National Laboratory, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA., Arts EJ; Department of Microbiology and Immunology, Western University, London, ON N6A 3K7, Canada.

Publikováno v: Vaccines [Vaccines (Basel)] 2023 May 12; Vol. 11 (5). Date of Electronic Publication: 2023 May 12.

Monovalent and trivalent VSV-based COVID-19 vaccines elicit neutralizing antibodies and CD8 ⁺ T cells against SARS-CoV-2 variants.

Autor: Parham KA; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 3K7, Canada., Kim GN; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 3K7, Canada., Richer CG; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 3K7, Canada., Ninkov M; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 3K7, Canada., Wu K; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 3K7, Canada., Saeedian N; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 3K7, Canada., Li Y; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 3K7, Canada., Rashu R; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 3K7, Canada., Barr SD; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 3K7, Canada., Arts EJ; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 3K7, Canada., Haeryfar SMM; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 3K7, Canada., Kang CY; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 3K7, Canada., Troyer RM; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 3K7, Canada.

Publikováno v: IScience [iScience] 2023 Apr 21; Vol. 26 (4), pp. 106292. Date of Electronic Publication: 2023 Feb 28.