ADAR1-dependent editing regulates human beta cell transcriptome diversity during inflammation

Autor: Szymczak, F., Cohen-Fultheim, R., Thomaidou, S., Brachene, A.C. de, Castela, A., Colli, M., Marchetti, P., Levanon, E., Eizirik, D., Zaldumbide, A.

Publikováno v: Frontiers in endocrinology
Frontiers in Endocrinology, 13. FRONTIERS MEDIA SA

IntroductionEnterovirus infection has long been suspected as a possible trigger for type 1 diabetes. Upon infection, viral double-stranded RNA (dsRNA) is recognized by membrane and cytosolic sensors that orchestrate type I interferon signaling and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7edc5bbc2444f027dd82354c7212a58
https://doi.org/10.3389/fendo.2022.1058345

INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes

Autor: Dunger, David B., Bruggraber, Sylvaine F. A., Mander, Adrian P., Marcovecchio, M. Loredana, Tree, Timothy, Chmura, Piotr Jaroslaw, Knip, Mikael, Schulte, Anke M., Mathieu, Chantal, Mathieu, C., Gillard, P., Casteels, K., Overbergh, L., Dunger, D., Wallace, C., Evans, M., Thankamony, A., Hendriks, E., Bruggraber, S., Peakman, M., Tree, T., Morgan, N., Richardson, S., Todd, J., Wicker, L., Mander, A., Dayan, C., Alhadj Ali, M., Pieber, T., Eizirik, D., Cnop, M., Brunak, S., Pociot, F., Johannesen, J., Rossing, P., Legido Quigley, C., Mallone, R., Scharfmann, R., Boitard, C., Knip, M., Otonkoski, T., Veijola, R., Lahesmaa, R., Oresic, M., Toppari, J., Danne, T., Ziegler, A. G., Achenbach, P., Rodriguez-Calvo, T., Solimena, M., Bonifacio, E., Speier, S., Holl, R., Dotta, F., Chiarelli, F., Marchetti, P., Bosi, E., Cianfarani, S., Ciampalini, P., de Beaufort, C., Dahl-Jørgensen, K., Skrivarhaug, T., Joner, G., Krogvold, L., Jarosz-Chobot, P., Battelino, T., Thorens, B., Gotthardt, M., Roep, B., Nikolic, T., Zaldumbide, A., Lernmark, A., Lundgren, M., Costecalde, G., Strube, T., Schulte, A., Nitsche, A., von Herrath, M., Wesley, J., Napolitano-Rosen, A., Thomas, M., Schloot, N., Goldfine, A., Waldron-Lynch, F., Kompa, J., Vedala, A., Hartmann, N., Nicolas, G., van Rampelbergh, J., Bovy, N., Dutta, S., Soderberg, J., Ahmed, S., Martin, F., Agiostratidou, G., Koralova, A., Willemsen, R., Smith, A., Anand, B., Puthi, V., Zac-Varghese, S., Datta, V., Dias, R., Sundaram, P., Vaidya, B., Patterson, C., Owen, K., Piel, B., Heller, S., Randell, T., Gazis, T., Bismuth Reismen, E., Carel, J-C, Riveline, J-P, Gautier, J-F, Andreelli, F., Travert, F., Cosson, E., Penfornis, A., Petit, C., Feve, B., Lucidarme, N., Beressi, J-P, Ajzenman, C., Radu, A., Greteau-Hamoumou, S., Bibal, C., Meissner, T., Heidtmann, B., Toni, S., Rami-Merhar, B., Eeckhout, B., Peene, B., Vantongerloo, N., Maes, T., Gommers, L., Marcovecchio, M.L., Vela, J., Latres, E.

Publikováno v: Dunger, D B, Bruggraber, S F A, Mander, A P, Marcovecchio, M L, Tree, T, Chmura, P J, Knip, M, Schulte, A M, Mathieu, C & INNODIA consortium 2022, ' INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes ', Trials, vol. 23, no. 1, 414 . https://doi.org/10.1186/s13063-022-06259-z
Trials 23:414 (2022)

Background The INNODIA consortium has established a pan-European infrastructure using validated centres to prospectively evaluate clinical data from individuals with newly diagnosed type 1 diabetes combined with centralised collection of clinical sam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204b8f8261c567ae6812c50bb5718aea
https://doi.org/10.1186/s13063-022-06259-z

Gene expression signatures of target tissues in endocrine and non-endocrine autoimmune diseases. Presente par Prof. Miriam Cnop

Autor: Szymczak F, L. Colli M., J. Mamula M., Evans-Molina C, L Eizirik D.

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d96e2d9f611237da1baab5ab335e9834
https://doi.org/10.1530/endoabs.79.003

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