Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Eivor Örnskov"'
Autor:
Jörgen Samuelsson, Linda Thunberg, Fredrik Limé, Eivor Örnskov, Torgny Fornstedt, Martin Enmark, Joakim Bagge, Hanna Leek
Publikováno v:
Analytical and Bioanalytical Chemistry
Oligonucleotide drugs represent an emerging area in the pharmaceutical industry. Solid-phase synthesis generates many structurally closely related impurities, making efficient separation systems for purification and analysis a key challenge during ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faab313cb73d48cdc0fb8b4c7726ae96
https://doi.org/10.1007/s00216-019-02236-9
https://doi.org/10.1007/s00216-019-02236-9
Autor:
Fritz Schweikart, Jacob. R Dahlberg, Jonathan Currie, Jonas Eriksson, Gunilla. A Nilsson, Eivor Örnskov
Modified messenger RNA (mRNA) represents a promising new class of therapeutic drug product. Development of robust stability indicating methods, for control of product quality, are therefore critical to support successful pharmaceutical development. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db7c26a32207fb22864c89dbae5c317
https://doi.org/10.26434/chemrxiv-2021-mgx9q
https://doi.org/10.26434/chemrxiv-2021-mgx9q
Autor:
Said Harun, Eivor Örnskov, Anders Dahlén, Linda Thunberg, Torgny Fornstedt, Martin Enmark, Jörgen Samuelsson
A B S T R A C T Here it was investigated how oligonucleotide retention and selectivity factors are affected by electrostatic and non-electrostatic interactions in ion pair chromatography. A framework was derived describing how selectivity depends on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1ff576e3d66a4394585a43ac707378
http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-85296
http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-85296
Autor:
Eivor Örnskov, Maria Rova, Fritz Schweikart, Martin Enmark, Torgny Fornstedt, Jörgen Samuelsson
Publikováno v:
Analytical and Bioanalytical Chemistry
This study presents a systematic investigation of factors influencing the chromatographic separation of diastereomers of phosphorothioated pentameric oligonucleotides as model solutes. Separation was carried out under ion-pairing conditions using an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39970c0f9751c225b971698849cb2d6
http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-72453
http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-72453
Publikováno v:
Journal of chromatography. A. 1562
Modified messenger RNA (mRNA) has recently become a new prospective class of drug product. Consequently, stability indicating separation methods are needed to progress pharmaceutical development of mRNA. A promising separation technique for the analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52a681e75d01141700dbc3dd4d74cb0
https://pubmed.ncbi.nlm.nih.gov/29843943
https://pubmed.ncbi.nlm.nih.gov/29843943
Publikováno v:
Journal of pharmaceutical sciences. 104(12)
The oxidation reaction of pyridine by hydrogen peroxides in water media was investigated by combining quantum chemical calculations and laboratory experiments. Pyridine was selected as a model system for aromatic amines that frequently occurs in drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9da13bf1a5eb34704a2068e3f3142f
https://pubmed.ncbi.nlm.nih.gov/26523412
https://pubmed.ncbi.nlm.nih.gov/26523412
Publikováno v:
Journal of Pharmacy and Pharmacology. 57:435-442
Capillary electrophoresis (CE) was evaluated as an in-vitro format for experimental modelling of membrane permeability using only nanogram quantities of drug compounds. The rationale for the CE technique emanates from emulation of a lipid-like pseudo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b08278d2e75a8cd2029c6bcc704ca50
https://doi.org/10.1211/0022357055867
https://doi.org/10.1211/0022357055867
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 33:379-391
The utility of capillary electrophoresis (CE) for determination of the negative logarithm of dissociation constants (pK(a)) of labile compounds was investigated. In this study pyridinyl-methyl-sulfinyl-benzimidazoles (PMSB's), which have both an acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beddc4a4430d29bb55709b6aabd3381d
https://doi.org/10.1016/s0731-7085(03)00238-3
https://doi.org/10.1016/s0731-7085(03)00238-3
Publikováno v:
ELECTROPHORESIS. 23:3381-3384
A novel procedure for immobilization of liposomes inside fused-silica capillaries is demonstrated. First, the inner wall of the capillaries was coated with a positively charged polymer, composed of derivatized agarose. Subsequently, negatively charge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f2604326f534a10b441755d077b0ab3
https://doi.org/10.1002/1522-2683(200210)23:19<3381::aid-elps3381>3.0.co
https://doi.org/10.1002/1522-2683(200210)23:19<3381::aid-elps3381>3.0.co
Publikováno v:
Journal of pharmaceutical sciences. 104(4)
We have developed a predictive method, based on quantum chemical calculations, that qualitatively predicts N-oxidation by hydrogen peroxides in drug structures. The method uses linear correlations of two complementary approaches to estimate the activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afc7ac1e7035ed1692974a9ac27fcf8
https://pubmed.ncbi.nlm.nih.gov/25712623
https://pubmed.ncbi.nlm.nih.gov/25712623