Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Eitan M. Akirav"'
Autor:
John A. Olsen, Lauren A. Kenna, Regine C. Tipon, Michael G. Spelios, Mark M. Stecker, Eitan M. Akirav
Publikováno v:
EBioMedicine, Vol 10, Iss C, Pp 227-235 (2016)
Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system (CNS). Minimally invasive biomarkers of MS are required for disease diagnosis and treatment. Differentially methylated circulating-free DNA (cfDNA) is a useful bioma
Externí odkaz:
https://doaj.org/article/2f52b81ca96c44a088633b9229625d60
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152662 (2016)
In type 1 diabetes (T1D), β-cell loss is silent during disease progression. Methylation-sensitive quantitative real-time PCR (qPCR) of β-cell-derived DNA in the blood can serve as a biomarker of β-cell death in T1D. Amylin is highly expressed by
Externí odkaz:
https://doaj.org/article/03ee49d3aa814d6d8258aa03677d5235
Autor:
Eitan M Akirav, Paula Preston-Hurlburt, Justin Garyu, Octavian Henegariu, Raphael Clynes, Ann Marie Schmidt, Kevan C Herold
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34698 (2012)
The Receptor for Advanced Glycation Endproducts (RAGE) is a scavenger ligand that binds glycated endproducts as well as molecules released during cell death such as S100b and HMGB1. RAGE is expressed on antigen presenting cells where it may participa
Externí odkaz:
https://doaj.org/article/e26c0852b8f34eefad5e01072c80692a
Autor:
Martin J. Hessner, Jared M. Odegard, Eddie A. James, Alberto Pugliese, Megan K. Levings, S. Alice Long, Raphael Gottardo, Elizabeth Whalen, Dror Berel, William Chad Young, Anne M. Pesenacker, Eitan M. Akirav, Peter S. Linsley, Matthew J. Dufort, Samuel O. Skinner, Cate Speake, Gerald T. Nepom, Frans K. Gorus
At diagnosis, most people with type 1 diabetes (T1D) produce measurable levels of endogenous insulin, but the rate at which insulin secretion declines is heterogeneous. To explain this heterogeneity, we sought to identify a composite signature predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b237eb399f4c696b73c3089204ac4f61
https://hdl.handle.net/20.500.14017/ad1c22ad-24e5-4641-9e96-e70d7e73fa70
https://hdl.handle.net/20.500.14017/ad1c22ad-24e5-4641-9e96-e70d7e73fa70
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 314(5)
Three-dimensional (3D) pseudoislets (PIs) can be used for the study of insulin-producing β-cells in free-floating islet-like structures similar to that of primary islets. Previously, we demonstrated the ability of islet-derived endothelial cells (iE
Publikováno v:
Journal of Biological Chemistry. 290:15250-15259
The co-culturing of insulinoma and islet-derived endothelial cell (iEC) lines results in the spontaneous formation of free-floating pseudoislets (PIs). We previously showed that iEC-induced PIs display improved insulin expression and secretion in res
Autor:
John A. Olsen, Eitan M. Akirav
Publikováno v:
Journal of Neuroscience Research. 93:687-696
The myelin sheath that coats axons allows rapid propagation of electrical impulses across the nervous system. Oligodendrocytes (ODs) are myelin-producing cells of the central nervous system (CNS) responsible for wrapping the axons of neurons. Multipl
Publikováno v:
Diabetology & Metabolic Syndrome
Background Gestational diabetes mellitus (GDM) affects approximately 7–17 % of all pregnancies and has been recognized as a significant risk factor to neonatal and maternal health. Postpartum, GDM significantly increases the likelihood of developin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 4, p e0152662 (2016)
PLoS ONE, Vol 11, Iss 4, p e0152662 (2016)
In type 1 diabetes (T1D), β-cell loss is silent during disease progression. Methylation-sensitive quantitative real-time PCR (qPCR) of β-cell-derived DNA in the blood can serve as a biomarker of β-cell death in T1D. Amylin is highly expressed by
Autor:
Octavian Henegariu, Vitaly Ablamunits, Jasmin Lebastchi, Paul M. Lizardi, Michael Akirav, Kevan C. Herold, Eitan M. Akirav, Eva M. Galvan
Publikováno v:
Proceedings of the National Academy of Sciences. 108:19018-19023
In diabetes mellitus, β cell destruction is largely silent and can be detected only after significant loss of insulin secretion capacity. We have developed a method for detecting β cell death in vivo by amplifying and measuring the proportion of in