Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Eitan M. Akirav"'
Autor:
John A. Olsen, Lauren A. Kenna, Regine C. Tipon, Michael G. Spelios, Mark M. Stecker, Eitan M. Akirav
Publikováno v:
EBioMedicine, Vol 10, Iss C, Pp 227-235 (2016)
Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system (CNS). Minimally invasive biomarkers of MS are required for disease diagnosis and treatment. Differentially methylated circulating-free DNA (cfDNA) is a useful bioma
Externí odkaz:
https://doaj.org/article/2f52b81ca96c44a088633b9229625d60
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152662 (2016)
In type 1 diabetes (T1D), β-cell loss is silent during disease progression. Methylation-sensitive quantitative real-time PCR (qPCR) of β-cell-derived DNA in the blood can serve as a biomarker of β-cell death in T1D. Amylin is highly expressed by
Externí odkaz:
https://doaj.org/article/03ee49d3aa814d6d8258aa03677d5235
Autor:
Eitan M Akirav, Octavian Henegariu, Paula Preston-Hurlburt, Ann Marie Schmidt, Raphael Clynes, Kevan C Herold
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95678 (2014)
The receptor for glycation end products (RAGE) has been previously implicated in shaping the adaptive immune response. RAGE is expressed in T cells after activation and constitutively in T cells from patients with diabetes. The effects of RAGE on ada
Externí odkaz:
https://doaj.org/article/d215d42236e04f0f9da990da3b2b8f9f
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72260 (2013)
β cell pseudoislets (PIs) are used for the in vitro study of β-cells in a three-dimensional (3-D) configuration. Current methods of PI induction require unique culture conditions and extensive mechanical manipulations. Here we report a novel co-cul
Externí odkaz:
https://doaj.org/article/d0b638ae70094e75978c6566ff6778b1
Autor:
Eitan M Akirav, Paula Preston-Hurlburt, Justin Garyu, Octavian Henegariu, Raphael Clynes, Ann Marie Schmidt, Kevan C Herold
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34698 (2012)
The Receptor for Advanced Glycation Endproducts (RAGE) is a scavenger ligand that binds glycated endproducts as well as molecules released during cell death such as S100b and HMGB1. RAGE is expressed on antigen presenting cells where it may participa
Externí odkaz:
https://doaj.org/article/e26c0852b8f34eefad5e01072c80692a
Autor:
Martin J. Hessner, Jared M. Odegard, Eddie A. James, Alberto Pugliese, Megan K. Levings, S. Alice Long, Raphael Gottardo, Elizabeth Whalen, Dror Berel, William Chad Young, Anne M. Pesenacker, Eitan M. Akirav, Peter S. Linsley, Matthew J. Dufort, Samuel O. Skinner, Cate Speake, Gerald T. Nepom, Frans K. Gorus
At diagnosis, most people with type 1 diabetes (T1D) produce measurable levels of endogenous insulin, but the rate at which insulin secretion declines is heterogeneous. To explain this heterogeneity, we sought to identify a composite signature predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b237eb399f4c696b73c3089204ac4f61
https://hdl.handle.net/20.500.14017/ad1c22ad-24e5-4641-9e96-e70d7e73fa70
https://hdl.handle.net/20.500.14017/ad1c22ad-24e5-4641-9e96-e70d7e73fa70
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 314(5)
Three-dimensional (3D) pseudoislets (PIs) can be used for the study of insulin-producing β-cells in free-floating islet-like structures similar to that of primary islets. Previously, we demonstrated the ability of islet-derived endothelial cells (iE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d5245311a160552c5ee834a94a72fc
https://pubmed.ncbi.nlm.nih.gov/29351476
https://pubmed.ncbi.nlm.nih.gov/29351476
Publikováno v:
Journal of Biological Chemistry. 290:15250-15259
The co-culturing of insulinoma and islet-derived endothelial cell (iEC) lines results in the spontaneous formation of free-floating pseudoislets (PIs). We previously showed that iEC-induced PIs display improved insulin expression and secretion in res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7eb1514cb30cc07e22ae3155716556
https://doi.org/10.1074/jbc.m114.628784
https://doi.org/10.1074/jbc.m114.628784
Autor:
John A. Olsen, Eitan M. Akirav
Publikováno v:
Journal of Neuroscience Research. 93:687-696
The myelin sheath that coats axons allows rapid propagation of electrical impulses across the nervous system. Oligodendrocytes (ODs) are myelin-producing cells of the central nervous system (CNS) responsible for wrapping the axons of neurons. Multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c97592766c6b87c8379ba487b0ace8c4
https://doi.org/10.1002/jnr.23493
https://doi.org/10.1002/jnr.23493
Publikováno v:
Diabetology & Metabolic Syndrome
Background Gestational diabetes mellitus (GDM) affects approximately 7–17 % of all pregnancies and has been recognized as a significant risk factor to neonatal and maternal health. Postpartum, GDM significantly increases the likelihood of developin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d550182a2775c6f32fe89e5c5af5b86a
https://doi.org/10.1186/s13098-016-0175-z
https://doi.org/10.1186/s13098-016-0175-z