Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Eitan Hoch"'
Publikováno v:
Cell Reports, Vol 29, Iss 3, Pp 778-780 (2019)
Summary: Human genetic variants in SLC16A11 are associated with increased risk of type 2 diabetes (T2D). We previously identified two distinct mechanisms through which co-inherited T2D-risk coding and non-coding variants disrupt SLC16A11 expression a
Externí odkaz:
https://doaj.org/article/550289bc10b64e26a825c247f4419f07
Autor:
Sarah Jeanfavre, Kerry A. Pierce, Eitan Hoch, Alina Ainbinder, Suzanne B.R. Jacobs, Federico Centeno-Cruz, Courtney Dennis, Karen Gelinas-Roa, Amy Deik, Lorena Orozco, Patricia Glover, Kevin Bullock, Jesse Krejci, Francisco Barajas-Olmos, Anthony N. Hollenberg, Jose C. Florez, Carlos Zerrweck, Liping Zhao, Clary B. Clish, Eric S. Lander, Jinyoung Choi, Alycen Harney, Victor Rusu
SUMMARYGenetic variation at the SLC16A11 locus contributes to the disproportionate impact of type 2 diabetes (T2D) on Latino populations. We recently demonstrated that T2D risk variants reduce SLC16A11 liver expression and function of MCT11, the mono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe176c8174e9997c0a00611592c8eb5f
https://doi.org/10.1101/2021.09.08.459307
https://doi.org/10.1101/2021.09.08.459307
Autor:
Michal Hershfinkel, Moshe Levy, Shiran Barber-Zucker, Raz Zarivach, Eitan Hoch, Nadav Elkoshi, Israel Sekler
Publikováno v:
Journal of Biological Chemistry. 294:5879-5889
Manganese (Mn(2+)) is extruded from the cell by the zinc transporter 10 (ZnT10). Loss of ZnT10 expression caused by autosomal mutations in the ZnT10 gene leads to hypermanganesemia in multiple organs. Here, combining fluorescent monitoring of cation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f6f3ef8da7e3320dd4ffdaf9b330b6
https://doi.org/10.1074/jbc.ra118.006816
https://doi.org/10.1074/jbc.ra118.006816
Autor:
Israel Sekler, Yusaku Miyamae, Masaya Nagao, Eitan Hoch, Kazuhisa Fukue, Tokuji Tsuji, Dax Fu, Ayako Fukunaka, Taiho Kambe, Seiji Masuda, Taka-aki Takeda, Takashi Fujiwara, Chengfeng Merriman, Yukina Nishito, Shigeyuki Fujimoto
Publikováno v:
Biochemical Journal. 473:2611-2621
Secretory and membrane-bound zinc-requiring enzymes are thought to be activated by binding zinc in the early secretory pathway. One such enzyme, tissue-non-specific alkaline phosphatase (TNAP), is activated through a two-step mechanism, via protein s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d7f2de1041fb43fbda1ec78032375a
https://doi.org/10.1042/bcj20160324
https://doi.org/10.1042/bcj20160324
Autor:
Eitan Hoch
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63c99cd9474ad6461508ca68380590f4
https://doi.org/10.1016/j.dmpk.2020.04.306
https://doi.org/10.1016/j.dmpk.2020.04.306
Autor:
Eitan Hoch, Israel Sekler
Cellular Zn2+homeostasis is tightly regulated and primarily mediated by designated Zn2+transport proteins, namely ZnTs (SLC30) that shuttle Zn2+efflux, and ZIPs (SLC39) that mediate Zn2+influx. While the functional determinants of ZnT-mediated Zn2+ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ede8a31857f36b102d315767d34e85
https://doi.org/10.1101/474528
https://doi.org/10.1101/474528
Autor:
Victor Rusu, Eitan Hoch, Josep M. Mercader, Danielle E. Tenen, Melissa Gymrek, Christina R. Hartigan, Michael DeRan, Marcin von Grotthuss, Pierre Fontanillas, Alexandra Spooner, Gaelen Guzman, Amy A. Deik, Kerry A. Pierce, Courtney Dennis, Clary B. Clish, Steven A. Carr, Bridget K. Wagner, Monica Schenone, Maggie C.Y. Ng, Brian H. Chen, Federico Centeno-Cruz, Carlos Zerrweck, Lorena Orozco, David M. Altshuler, Stuart L. Schreiber, Jose C. Florez, Suzanne B.R. Jacobs, Eric S. Lander, Daniel Shriner, Jiang Li, Wei-Min Chen, Xiuqing Guo, Jiankang Liu, Suzette J. Bielinski, Lisa R. Yanek, Michael A. Nalls, Mary E. Comeau, Laura J. Rasmussen-Torvik, Richard A. Jensen, Daniel S. Evans, Yan V. Sun, Ping An, Sanjay R. Patel, Yingchang Lu, Jirong Long, Loren L. Armstrong, Lynne Wagenknecht, Lingyao Yang, Beverly M. Snively, Nicholette D. Palmer, Poorva Mudgal, Carl D. Langefeld, Keith L. Keene, Barry I. Freedman, Josyf C. Mychaleckyj, Uma Nayak, Leslie J. Raffel, Mark O. Goodarzi, Y-D Ida Chen, Herman A. Taylor, Adolfo Correa, Mario Sims, David Couper, James S. Pankow, Eric Boerwinkle, Adebowale Adeyemo, Ayo Doumatey, Guanjie Chen, Rasika A. Mathias, Dhananjay Vaidya, Andrew B. Singleton, Alan B. Zonderman, Robert P. Igo, John R. Sedor, Edmond K. Kabagambe, David S. Siscovick, Barbara McKnight, Kenneth Rice, Yongmei Liu, Wen-Chi Hsueh, Wei Zhao, Lawrence F. Bielak, Aldi Kraja, Michael A. Province, Erwin P. Bottinger, Omri Gottesman, Qiuyin Cai, Wei Zheng, William J. Blot, William L. Lowe, Jennifer A. Pacheco, Dana C. Crawford, Elin Grundberg, Stephen S. Rich, M. Geoffrey Hayes, Xiao-Ou Shu, Ruth J.F. Loos, Ingrid B. Borecki, Patricia A. Peyser, Steven R. Cummings, Bruce M. Psaty, Myriam Fornage, Sudha K. Iyengar, Michele K. Evans, Diane M. Becker, W.H. Linda Kao, James G. Wilson, Jerome I. Rotter, Michèle M. Sale, Simin Liu, Charles N. Rotimi, Donald W. Bowden, Alicia Huerta-Chagoya, Humberto García-Ortiz, Hortensia Moreno-Macías, Alisa Manning, Lizz Caulkins, Noël P. Burtt, Jason Flannick, Nick Patterson, Carlos A. Aguilar-Salinas, Teresa Tusié-Luna, David Altshuler, Angélica Martínez-Hernández, Francisco Martin Barajas-Olmos, Cecilia Contreras-Cubas, Elvia Mendoza-Caamal, Cristina Revilla-Monsalve, Sergio Islas-Andrade, Emilio Córdova, Xavier Soberón, Clicerio González-Villalpando, María Elena González-Villalpando, Christopher A. Haiman, Lynne Wilkens, Loic Le Marchand, Kristine Monroe, Laurence Kolonel, Olimpia Arellano-Campos, Maria L. Ordóñez-Sánchez, Maribel Rodríguez-Torres, Yayoi Segura-Kato, Rosario Rodríguez-Guillén, Ivette Cruz-Bautista, Linda Liliana Muñoz-Hernandez, Tamara Sáenz, Donají Gómez, Ulices Alvirde, Paloma Almeda-Valdés, Maria L. Cortes
Publikováno v:
PMC
Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the increased T2D prevalence in Mexico. Here, through genetic fine-mapp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181ad6c0864ec07b3726b9ab528f5806
https://pubmed.ncbi.nlm.nih.gov/28666114
https://pubmed.ncbi.nlm.nih.gov/28666114
Publikováno v:
Proceedings of the National Academy of Sciences. 109:7202-7207
Zinc and cadmium are similar metal ions, but though Zn 2+ is an essential nutrient, Cd 2+ is a toxic and common pollutant linked to multiple disorders. Faster body turnover and ubiquitous distribution of Zn 2+ vs. Cd 2+ suggest that a mammalian metal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a59d92159fe31727ced9d236576bd1a
https://doi.org/10.1073/pnas.1200362109
https://doi.org/10.1073/pnas.1200362109
Autor:
Ofer Yifrach, Israel Sekler, Chen Keasar, Eitan Hoch, Taiho Kambe, Ehud Ohana, Michal Hershfinkel
Publikováno v:
The Journal of biological chemistry. 284(26)
Vesicular zinc transporters (ZnTs) play a critical role in regulating Zn2+ homeostasis in various cellular compartments and are linked to major diseases ranging from Alzheimer disease to diabetes. Despite their importance, the intracellular localizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6175c24dd08c09c28348661bcb8b49f
https://pubmed.ncbi.nlm.nih.gov/19366695
https://pubmed.ncbi.nlm.nih.gov/19366695