Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Eisaku Mizuguchi"'
Autor:
Takahide Watanabe, Nobuo Shimma, Yoshikazu Ohya, Hiroshi Fukuda, Osamu Kondoh, Mikio Arisawa, Eisaku Mizuguchi, Yuko Aoki, Yukiko Inagaki, Masahiro Sakaitani
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:2138-2141
1,3-beta-D-Glucan synthase, which synthesizes a main component of fungal cell wall, is one of the promising targets for antifungal agents. In order to identify novel chemical classes of 1,3-beta-D-glucan synthase inhibitors, we screened a chemical li
Autor:
Takahide Watanabe, Toshikazu Yamazaki, Tomoaki Inoue, Yasuko Satoh, Kazuko Kobayashi, Kazunao Masubuchi, Takehiro Okada, Ikuo Horii, Eisaku Mizuguchi, Masahiro Aoki, Masahiro Sakaitani, Haruyoshi Shirai, Nobuo Shimma, Masami Kohchi, Osamu Kondoh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:395-398
Highly potent 1,3-β- d -glucan synthase inhibitors, 7b , 10a , 10b and 12 , have been identified by the chemical modification of the ornithine residue of a fungicidal macrocyclic lipopeptidolactone, RO-09-3655 ( 1 ), isolated from the cultured broth
Publikováno v:
Tetrahedron: Asymmetry. 5:1407-1410
Chiral non-racemic 5,5-disubstituted hydantoins were prepared by lipase-catalyzed enantioselective hydrolyses of their N -acyloxymethyl groups or esterification of their N -hydroxymethyl groups.
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 52:638-648
The synthetic method of optically active compound by using lipase-catalysis in organic solvent has been generally accepted recently. Because lipases possess especially broad substrate specificity and are commercially available. However, efficient sub
Autor:
Kazuo Achiwa, Eisaku Mizuguchi
Publikováno v:
Tetrahedron: Asymmetry. 4:2303-2306
The d-α-tocopherol was synthesized effectively by enzyme-catalyzed enantioselective hydrolysis of dl-α-tocopherol oxalate. The enzymes can recognize a stereogenic carbon atom remote from the reaction site.
Publikováno v:
Tetrahedron: Asymmetry. 4:1961-1964
The natural α-tocopherol was synthesized by enzyme-catalyzed enantioselective hydrolysis. The unnatural enantiomer as a baby-product was also converted to natural α-tocopherol by racemerization and repeated enzyme-catalyzed hydrolysis.
Autor:
Ryoichi Saitoh, Takaaki Miura, Takeshi Murata, Yasuaki Matsubara, Christine Lukacs, Eisaku Mizuguchi, Nobuo Shimma, Yasunori Chugai Seiyaku Kabushiki Kaisha Kohchi, Charles Belunis, Hisafumi Okabe, Yoshiaki Isshiki, Masanori Miwa, Verena Schück, Kohsuke Asoh, Kazuo Hattori, Hitoshi Iikura, Shinji Chugai Seiyaku Kabushiki Kaisha Tsujii, Naoaki Murao, Masami Kohchi, Cheryl Janson, Yasushi Yoshimura, Satoshi Aida
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(6)
The MAP kinase pathway is one of the most important pathways involved in cell proliferation and differentiation, and its components are promising targets for antitumor drugs. Design and synthesis of a novel MEK inhibitor, based on the 3D-structural i
Publikováno v:
ChemInform. 25
The natural α-tocopherol was synthesized by enzyme-catalyzed enantioselective hydrolysis. The unnatural enantiomer as a baby-product was also converted to natural α-tocopherol by racemerization and repeated enzyme-catalyzed hydrolysis.
Autor:
Kazuo Achiwa, Eisaku Mizuguchi
Publikováno v:
ChemInform. 25
The d-α-tocopherol was synthesized effectively by enzyme-catalyzed enantioselective hydrolysis of dl-α-tocopherol oxalate. The enzymes can recognize a stereogenic carbon atom remote from the reaction site.
Publikováno v:
ChemInform. 26
The synthetic method of optically active compound by using lipase-catalysis in organic solvent has been generally accepted recently. Because lipases possess especially broad substrate specificity and are commercially available. However, efficient sub