Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Eirini Maniou"'
Autor:
Gabriel L. Galea, Eirini Maniou, Timothy J. Edwards, Abigail R. Marshall, Ioakeim Ampartzidis, Nicholas D. E. Greene, Andrew J. Copp
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Mutations that cause tissue mosaicism have been identified in individuals with severe congenital defects. Here, the authors show that mosaic deletion of Vangl2 in the murine neuroepithlium causes spina bifida by preventing apical constriction via red
Externí odkaz:
https://doaj.org/article/52e4848101894d13b8f2a7a3e588a063
Autor:
Gi Fay Mok, Leighton Folkes, Shannon A. Weldon, Eirini Maniou, Victor Martinez-Heredia, Alice M. Godden, Ruth M. Williams, Tatjana Sauka-Spengler, Grant N. Wheeler, Simon Moxon, Andrea E. Münsterberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
How paraxial mesoderm formation and differentiation is regulated is unclear. Here, the authors identify accessible chromatin and gene expression signatures that define different stages of paraxial mesoderm development in the chick and identify CREs i
Externí odkaz:
https://doaj.org/article/83e65e791fea4260aa9246e9733957f6
Autor:
Gabriel L. Galea, Eirini Maniou, Timothy J. Edwards, Abigail R. Marshall, Ioakeim Ampartzidis, Nicholas D. E. Greene, Andrew J. Copp
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/b734718cc4534036baddc2e2aa44a9d3
Autor:
Eirini Maniou, Faduma Farah, Zoe Crane-Smith, Andrea Krstevski, Athanasia Stathopoulou, Nicholas D.E. Greene, Andrew J. Copp, Gabriel L. Galea
Closed spinal dysraphisms are poorly understood neurodevelopmental malformations commonly classed as neural tube defects. Several, including terminal myelocystocele, selectively affect the distal lumbosacral spine. We previously identified a neural t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::264aa28891fd752243be70435c7ff718
https://doi.org/10.1101/2023.03.07.531511
https://doi.org/10.1101/2023.03.07.531511
Autor:
Ioakeim Ampartzidis, Christoforos Efstathiou, Francesco Paonessa, Elliott M Thompson, Tyler Wilson, Conor J McCann, Nicholas DE Greene, Andrew Copp, Frederick J Livesey, Nicola Elvassore, Giovanni Giuseppe Giobbe, Paolo De Coppi, Eirini Maniou, Gabriel L Galea
Publikováno v:
Developmental biology.
Neuroepithelial cells balance tissue growth requirement with the morphogenetic imperative of closing the neural tube. They apically constrict to generate mechanical forces which elevate the neural folds, but are thought to apically dilate during mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67494b7335124d1202d3303c853afd98
https://pubmed.ncbi.nlm.nih.gov/36509125
https://pubmed.ncbi.nlm.nih.gov/36509125
Autor:
Eirini Maniou, Silvia Todros, Anna Urciuolo, Dale Moulding, Michael Magnusson, Monica Giomo, Piero G. Pavan, Gabriel L. Galea, Nicola Elvassore
Morphogenesis, the establishment of rudimentary organ structures, requires embryonic cells to generate forces and perform mechanical work to shape their tissues. Incorrect functioning of these force fields can lead to congenital malformations includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f818579a5a59be1c60da251c24bbf35
https://doi.org/10.21203/rs.3.rs-1095730/v1
https://doi.org/10.21203/rs.3.rs-1095730/v1
Autor:
Abigail R. Marshall, Eirini Maniou, Dale Moulding, Nicholas D. E. Greene, Andrew J. Copp, Gabriel L. Galea
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071620342
Methods in Molecular Biology ISBN: 9781071620342
Laser ablation is routinely performed to infer mechanical tension in cells and tissues. Here we describe our method of two-photon laser ablation at the cellular and tissue level in mouse embryos. The primary outcome of these experiments is initial re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c16e48e3fed1e6a668fcf07403cabca
https://europepmc.org/articles/PMC7614166/
https://europepmc.org/articles/PMC7614166/
Autor:
Eirini Maniou, Lucy H. Culshaw, Andrew J. Copp, Gabriel L. Galea, Dawn Savery, Nicholas D. E. Greene
Publikováno v:
Birth Defects Research
CreERT2‐mediated gene recombination is widely applied in developmental biology research. Activation of CreERT2 is typically achieved by injection of tamoxifen in an oily vehicle into the peritoneal cavity of mid‐gestation pregnant mice. This can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a504611093865d13543a619cda16cb
https://doi.org/10.1002/bdr2.1628
https://doi.org/10.1002/bdr2.1628
Autor:
Gabriel L. Galea, Shiladitya Banerjee, Nicholas D. E. Greene, Abigail R. Marshall, Eirini Maniou, Michael F. Staddon, Andrew J. Copp
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Failure to biomechanically close the embryonic neural tube in the developing brain causes fatal anencephaly. Despite their clinical importance, which cellular force-generating mechanisms close the neural tube remains poorly understood. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054f80ed10a68c79c6f2ccf6f3a491ad
https://doi.org/10.1073/pnas.2023163118
https://doi.org/10.1073/pnas.2023163118
Autor:
Simon Moxon, Tatjana Sauka-Spengler, Eirini Maniou, Ruth M. Williams, Grant N. Wheeler, Gi Fay Mok, Leighton Folkes, Andrea Münsterberg, Alice M. Godden, Shannon A. Weldon, Victor Martinez-Heredia
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Somites arising from paraxial mesoderm are a hallmark of the segmented vertebrate body plan. They form sequentially during axis extension and generate musculoskeletal cell lineages. How paraxial mesoderm becomes regionalised along the axis and how th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ffc79d2dde5e8e685b445f90500ef8
https://doi.org/10.1038/s41467-021-21426-7
https://doi.org/10.1038/s41467-021-21426-7