Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Einar K Rofstad"'
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e40006 (2012)
PURPOSE: Interstitial fluid pressure (IFP) is highly elevated in many solid tumors. High IFP has been associated with low radiocurability and high metastatic frequency in human melanoma xenografts and with poor survival after radiation therapy in cer
Externí odkaz:
https://doaj.org/article/eec65a4510b8409e939350dfe92034a6
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract Background Melanoma patients with metastatic growth in the meninges have poor prognosis and few treatment options. Although treatment with BRAF inhibitors or immune checkpoint inhibitors has provided promising results, most patients with adv
Externí odkaz:
https://doaj.org/article/f2712a4d4a734033b684fe552de5049e
Autor:
Jon-Vidar Gaustad, Einar K. Rofstad
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Tumor hypoxia is a major cause of treatment resistance and poor survival in locally-advanced cervical carcinoma (LACC). It has been suggested that Ktrans and ve maps derived by dynamic contrast-enhanced magnetic resonance imaging can provide informat
Externí odkaz:
https://doaj.org/article/0c570132302e438884517447395b95a3
Autor:
Anette Hauge, Catherine S. Wegner, Jon-Vidar Gaustad, Trude G. Simonsen, Lise Mari K. Andersen, Einar K. Rofstad
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-12 (2017)
Abstract Background Abnormalities in the tumor microenvironment are associated with resistance to treatment, aggressive growth, and poor clinical outcome in patients with advanced cervical cancer. The potential of dynamic contrast-enhanced (DCE) MRI
Externí odkaz:
https://doaj.org/article/102478f43a154b1e89e4aeaa43eb7df7
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-10 (2017)
Abstract Background Studies investigating the oxygenation status and the development of hypoxia in microscopic tumors are sparse. The purpose of this study was to measure the extent of hypoxia in microscopic melanoma xenografts and to search for poss
Externí odkaz:
https://doaj.org/article/43761314d7414c10a89c5cf76dbee7a6
Autor:
Randi G. Syljuåsen, Einar K. Rofstad, Kinga Tkacz-Stachowska, Viola Nähse-Kumpf, Grete Hasvold
PDF - 491K, Supplementary Figure S1: Cell cycle progression following hypoxia treatment. Supplementary Figure S2: Clonogenic survival following depletion of CHK1 by siRNA transfection. Supplementary Figure S3: S phase damage in HCT116p53-/- and HT29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851723fd69fb19c9d51f32e5da1f3f39
https://doi.org/10.1158/1535-7163.22497537.v1
https://doi.org/10.1158/1535-7163.22497537.v1
Autor:
Randi G. Syljuåsen, Einar K. Rofstad, Kinga Tkacz-Stachowska, Viola Nähse-Kumpf, Grete Hasvold
Inhibitors of CHK1 are in clinical trials for cancer treatment in combination with DNA-damaging agents. Importantly, it was previously suggested that hypoxic cancer cells may be particularly sensitive to CHK1 inhibition. However, this suggestion was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5853574abc1174612c31dc42c0345299
https://doi.org/10.1158/1535-7163.c.6535647.v1
https://doi.org/10.1158/1535-7163.c.6535647.v1
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
The purpose of the study was to investigate vascularization, oxygenation, and the effect of sunitinib treatment in pancreatic ductal adenocarcinoma (PDAC). BxPC-3 and Capan-2 xenografts grown in dorsal window chambers were used as preclinical models
Externí odkaz:
https://doaj.org/article/2951126f349f4f889593a401e3069491
PDF file - 25K, Figure showing IFP and v0 versus tumor size for TS-415 and U-25 tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207242706f1e28e2dfdc9a4c022a5904
https://doi.org/10.1158/0008-5472.22395426
https://doi.org/10.1158/0008-5472.22395426