Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Eiman Mukhtar"'
Autor:
Seaho Kim, CheukMan C Au, Mohd Azrin Bin Jamalruddin, Naira Essam Abou-Ghali, Eiman Mukhtar, Luigi Portella, Adeline Berger, Daniel Worroll, Prerna Vatsa, David S Rickman, David M Nanus, Paraskevi Giannakakou
Publikováno v:
eLife, Vol 11 (2022)
Expression of the AR splice variant, androgen receptor variant 7 (AR-V7), in prostate cancer is correlated with poor patient survival and resistance to AR targeted therapies and taxanes. Currently, there is no specific inhibitor of AR-V7, while the m
Externí odkaz:
https://doaj.org/article/2dbc4df1b5624c61b2a0b3917507799c
Although treatment of prostate cancer has improved over the past several years, taxanes, such as cabazitaxel, remain the only form of effective chemotherapy that improves survival in patients with metastatic castration–resistant prostate cancer. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a6a8251094540914ad7b4f81037e0af
https://doi.org/10.1158/1535-7163.c.6538735.v1
https://doi.org/10.1158/1535-7163.c.6538735.v1
Figure S1. Effect of fisetin and cabazitaxel, and their combination in-vitro.Figure S2. Effect of fisetin and cabazitaxel treatment of metastatic growth of PC-3M-luc-6 cell-derived tumors in mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6490f8e14e47458cbf7eeca565a0e62e
https://doi.org/10.1158/1535-7163.22507597.v1
https://doi.org/10.1158/1535-7163.22507597.v1
Autor:
Mohd Azrin Bin Jamalruddin, CheukMan C Au, Seaho Kim, Naira Essam Abou-Ghali, Eiman Mukhtar, Luigi Portella, Adeline Berger, Daniel Worroll, Prerna Vatsa, David S Rickman, David M Nanus, Paraskevi Giannakakou
Publikováno v:
eLife. 11
Expression of the AR splice variant, androgen receptor variant 7 (AR-V7), in prostate cancer is correlated with poor patient survival and resistance to AR targeted therapies and taxanes. Currently, there is no specific inhibitor of AR-V7, while the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418f30910e7a7fac0462defcdf0ab66c
https://doi.org/10.7554/elife.73396
https://doi.org/10.7554/elife.73396
Autor:
Mohd Azrin Bin Jamalruddin, CheukMan C Au, Seaho Kim, Naira Essam Abou-Ghali, Eiman Mukhtar, Luigi Portella, Adeline Berger, Daniel Worroll, Prerna Vatsa, David S Rickman, David M Nanus, Paraskevi Giannakakou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49018e5f726083f9728d18f7cf76fab7
https://doi.org/10.7554/elife.73396.sa2
https://doi.org/10.7554/elife.73396.sa2
Autor:
Sarina Anne Piha-Paul, Daniel Worroll, Giuseppe Galletti, Eiman Mukhtar, Paraskevi Giannakakou, Shelly Schuster
Publikováno v:
Cancer drug resistance (Alhambra, Calif.)
Aim We reviewed the radiographic response of three patients with metastatic castration-resistant prostate cancer treated with CRXL301, a docetaxel nanoparticle. For these three patients, we isolated and analyzed circulating tumor cells (CTCs) to expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c12cc98a97bf0647ec4ef4ab1661a1
https://pubmed.ncbi.nlm.nih.gov/33062959
https://pubmed.ncbi.nlm.nih.gov/33062959
Autor:
Eiman Mukhtar, Daniel Worroll, Shelly Schuster, Giuseppe Galletti, Sarina Anne Piha-Paul, Paraskevi Giannakakou
Publikováno v:
Cancer Research. 80:3196-3196
We reviewed the radiographic response of three patients with metastatic castration-resistant prostate cancer (mCRPC) treated with CRLX301, a docetaxel nanoparticle. For these three patients, we isolated and analyzed circulating tumor cells (CTC) to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2c790039d1837591985db7082b64e8d
https://doi.org/10.1158/1538-7445.am2020-3196
https://doi.org/10.1158/1538-7445.am2020-3196
Autor:
Leigh Baxt, Seaho Kim, Mohd Azrin Jamalruddin, Eiman Mukhtar, Andrew Stamford, Michael Miller, Peter T. Meinke, Paraskevi Giannakakou, Stacia Kargman
Publikováno v:
Cancer Research. 79:1017-1017
Reactivation of androgen receptor (AR) signaling by active splice variants (AR-Vs) is one of key drivers of castration resistant prostate cancer (CRPC). AR-v7 is the most prevalent AR-V and its expression has been clinically associated with poor over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25f92f9defb145fcdd3792d3e43c0462
https://doi.org/10.1158/1538-7445.am2019-1017
https://doi.org/10.1158/1538-7445.am2019-1017
®Editorial Comment: Analysis of significant gene expression changes induced by MET ligands that were associated with increased motility and invasion by PC3M cells, and spontaneous metastasis by PC3M xenografts in mice, identified 72 of 345 genes (21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a4a6dd1fd90486ae4d4bf7c613d0be
https://europepmc.org/articles/PMC4570246/
https://europepmc.org/articles/PMC4570246/
Publikováno v:
Cancer Research. 77:5634-5634
Androgen receptor (AR) signaling is critical to not only hormone-sensitive but also advanced castration-resistant prostate cancer. AR inhibitors (abiraterone and enzalutamide), the next generation of androgen deprivation therapy (ADT) have been used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78a391355250d956bc74f14b3e899ba2
https://doi.org/10.1158/1538-7445.am2017-5634
https://doi.org/10.1158/1538-7445.am2017-5634