Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Eilrayna Gelyana"'
Autor:
Kristina Fredriksen, Stefanos Aivazidis, Karan Sharma, Kevin J. Burbidge, Caleb Pitcairn, Friederike Zunke, Eilrayna Gelyana, Joseph R. Mazzulli
Publikováno v:
Proc Natl Acad Sci U S A
GBA1 mutations that encode lysosomal β-glucocerebrosidase (GCase) cause the lysosomal storage disorder Gaucher disease (GD) and are strong risk factors for synucleinopathies, including Parkinson’s disease and Lewy body dementia. Only a subset of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce0f92965495addbb5aeb8b25ef7741e
https://doi.org/10.1073/pnas.2108489118
https://doi.org/10.1073/pnas.2108489118
Autor:
Sohee Jeon, Friederike Zunke, Eilrayna Gelyana, Nicholas J. Toker, Iva Stojkovska, Kristina Fredriksen, Nandkishore R. Belur, Haris Dzaferbegovic, Alexandra C. Moise, Joseph R. Mazzulli
Publikováno v:
Neuron. 97(1)
Summary α-Synuclein (α-syn) aggregation is a key event in Parkinson's disease (PD). Mutations in glycosphingolipid (GSL)-degrading glucocerebrosidase are risk factors for PD, indicating that disrupted GSL clearance plays a key role in α-syn aggreg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37fa788d763c5ffe73c35670dcce6a7
https://pubmed.ncbi.nlm.nih.gov/29290548
https://pubmed.ncbi.nlm.nih.gov/29290548
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(35)
Microglial dysfunction is increasingly recognized as a key contributor to the pathogenesis of Alzheimer9s disease (AD). Environmental enrichment (EE) is well documented to enhance neuronal form and function, but almost nothing is known about whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd679bd0c7abece9ac7fb87de746df7
https://pubmed.ncbi.nlm.nih.gov/28100733
https://pubmed.ncbi.nlm.nih.gov/28100733