Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Eilise M. Ryan"'
Autor:
Eilise M. Ryan, Pranvera Sadiku, Patricia Coelho, Emily R. Watts, Ailiang Zhang, Andrew J. M. Howden, Manuel A. Sanchez-Garcia, Martin Bewley, Joby Cole, Brian J. McHugh, Wesley Vermaelen, Bart Ghesquiere, Peter Carmeliet, Giovanny Rodriguez Blanco, Alex Von Kriegsheim, Yolanda Sanchez, William Rumsey, James F. Callahan, George Cooper, Nicholas Parkinson, Kenneth Baillie, Doreen A. Cantrell, John McCafferty, Gourab Choudhury, Dave Singh, David H. Dockrell, Moira K. B. Whyte, Sarah R. Walmsley
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 207:998-1011
Rationale: Chronic obstructive pulmonary disease (COPD) is a disease characterized by persistent airway inflammation and disordered macrophage function. The extent to which alterations in macrophage bioenergetics contribute to impaired antioxidant re
Autor:
Andrew J. M. Howden, Sarah R. Walmsley, Alex von Kriegsheim, Jens L. Hukelmann, Eilise M. Ryan, Rebecca S. Dickinson, Fiona Murphy, Gio Rodriguez Blanco, Bart Ghesquière, Patrícia Coelho, Doreen A. Cantrell, Emily R. Watts, Pranvera Sadiku, Robert Grecian, Ananda S. Mirchandani, Wesley Vermaelen, Tyler Morrison, Duncan Humphries, Tracie Plant, Moira K. B. Whyte, Andrew J. Finch
Publikováno v:
Watts, E R, Howden, A J M, Morrison, T, Sadiku, P, Hukelmann, J L, Von Kriegsheim, A, Ghesquière, B, Murphy, F, Mirchandani, A S, Humphries, D C, Grecian, R, Ryan, E M, Coelho, P, Rodriguez-blanco, G, Plant, T M, Dickinson, R S, Finch, A J, Vermaelen, W, Cantrell, D A, Whyte, M K B & Walmsley, S R 2021, ' Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism ', Journal of Clinical Investigation . https://doi.org/10.1172/JCI134073
Limiting dysfunctional neutrophilic inflammation while preserving effective immunity requires a better understanding of the processes that dictate neutrophil function in the tissues. Quantitative mass-spectrometry identified how inflammatory murine n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a5393e0379a24b90ce692f5f16f351
https://hdl.handle.net/20.500.11820/6ee67df8-79e3-477f-a412-02d6f22765b7
https://hdl.handle.net/20.500.11820/6ee67df8-79e3-477f-a412-02d6f22765b7
Autor:
Patrícia Coelho, Pranvera Sadiku, Alex von Kriegsheim, Leila Reyes, David H. Dockrell, Robert Grecian, Jordi Duran, Christopher J Graham, Simone Arienti, Abel Acosta-Sanchez, Veronica M. Dardé, Privjyot Jheeta, Ananda S. Mirchandani, Gordon G. Paterson, A. A. Roger Thompson, David Sammut, Tyler Morrison, Martin A. Bewley, Ailing Zhang, Joseph A Willson, Massimiliano Mazzone, Kenneth Baillie, Moira K. B. Whyte, Tobias Griessler, Sarah R. Walmsley, Emily R. Watts, Peter Carmeliet, Jessie-May Morgan, Eilise M. Ryan, John P. Thomson, Manuel A. Sanchez Garcia, Bart Ghesquière, Joan J. Guinovart, Richard R. Meehan, Gio Rodriguez-Blanco, Jason M. Young
Publikováno v:
Sadiku, P, Willson, J A, Ryan, E M, Sammut, D, Coelho, P, Watts, E R, Grecian, R, Young, J M, Bewley, M, Arienti, S, Mirchandani, A S, Sanchez Garcia, M A, Morrison, T, Zhang, A, Reyes, L, Griessler, T, Jheeta, P, Paterson, G G, Graham, C J, Thompson, J P, Baillie, K, Thompson, A A R, Morgan, J-M, Acosta-Sanchez, A, Dardé, V M, Duran, J, Guinovart, J J, Rodriguez-Blanco, G, Von Kriegsheim, A, Meehan, R R, Mazzone, M, Dockrell, D H, Ghesquiere, B, Carmeliet, P, Whyte, M K B & Walmsley, S R 2021, ' Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis ', Cell Metabolism, vol. 33, no. 2, pp. 411-423.e4 . https://doi.org/10.1016/j.cmet.2020.11.016
Cell Metabolism
Cell Metabolism
Summary Neutrophils can function and survive in injured and infected tissues, where oxygen and metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U-13C glucose, glutamine, and pyruvate, we observe that neutrophils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cad74cc910e5a97db33fae4b7012689
https://eprints.whiterose.ac.uk/169130/1/1-s2.0-S1550413120306513-main.pdf
https://eprints.whiterose.ac.uk/169130/1/1-s2.0-S1550413120306513-main.pdf
Autor:
David H. Dockrell, J Callahan, Joby Cole, Patrícia Coelho, JB McCafferty, Dave Singh, Richard C. Budd, Martin A. Bewley, MK Whyte, Sarah R. Walmsley, Eilise M. Ryan
Publikováno v:
BTS/BALR/BLF Early Career Investigator Awards.
COPD is set to become the third leading cause of death globally by 2023. To date, we have no significant disease modifying therapies. COPD patients experience chronic inflammation and defective innate immunity, largely driven by macrophage dysfunctio
Autor:
Ajm Howden, Ananda S. Mirchandani, Patrícia Coelho, Rebecca S. Dickinson, Tracie Plant, A von Kriegsheim, Wesley Vermaelen, Fiona Murphy, Doreen A. Cantrell, Emily R. Watts, Andrew J. Finch, Pranvera Sadiku, Jens L. Hukelmann, Robert Grecian, Duncan Humphries, MK Whyte, Eilise M. Ryan, Sarah R. Walmsley, Bart Ghesquière
Publikováno v:
Fuelling the fire: inflammation and infection in lung disease.
Introduction and objectives Acute Respiratory Distress Syndrome (ARDS) is characterised by neutrophil driven alveolar and vascular injury. Alveolar damage is associated with worsening hypoxia and increased mortality. Specific therapies targeting neut
Publikováno v:
Ryan, E M, Whyte, M K & Walmsley, S R 2018, ' Hypoxia and reprogramming of host pathogen interactions ', Current opinion in physiology, vol. 7, pp. 15-20 . https://doi.org/10.1016/j.cophys.2018.11.004
Upregulation of key transcriptional pathways in response to hypoxia enables host responses to readily adapt to hypoxic environments, with preservation of key immune functions. Recent discoveries have highlighted the ability of hypoxia and its master
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893a2ef5285567f9fb22b43892949b70
https://hdl.handle.net/20.500.11820/71f72bfd-b8e8-4bda-9ef5-660cf819a740
https://hdl.handle.net/20.500.11820/71f72bfd-b8e8-4bda-9ef5-660cf819a740
Autor:
Iain Kilty, Dave Singh, Eilise M. Ryan, Ppeter J. Barnes, Gussie Beech, Richard D. Emes, Irina Tcherniaeva, Louise E. Donnelly, Sarah R. Walmsley, Moira K. B. Whyte, Jadwiga A. Wedzicha, Martin A. Bewley, Umme Kolsum, Joby Cole, Jennifer L. Marshall, William L. Rumsey, Richard C. Budd, Yolanda Sanchez, Christopher E. Brightling, Gavin C. Donaldson, Gguy A.M. Berbers, David H. Dockrell, Paul Collini
Publikováno v:
Bewley, M A, Budd, R C, Ryan, E, Cole, J, Collini, P, Marshall, J, Kolsum, U, Beech, G, Emes, R D, Tcherniaeva, I, Berbers, G A M, Walmsley, S R, Donaldson, G, Wedzicha, J A, Kilty, I, Rumsey, W, Sanchez, Y, Brightling, C E, Donnelly, L E, Barnes, P J, Singh, D & Whyte, M K B & Dockrell, D H 2018, ' Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists ', American Journal of Respiratory and Critical Care Medicine, vol. 198, no. 6, pp. 739-750 . https://doi.org/10.1164/rccm.201705-0903OC
Bewley, M A, Budd, R C, Ryan, E, Cole, J, Collini, P, Marshall, J, Kolsum, U, Beech, G, Emes, R D, Tcherniaeva, I, Berbers, G A M, Walmsley, S R, Donaldson, G, Wedzicha, J A, Kilty, I, Rumsey, W, Sanchez, Y, Brightling, C, Donnelly, L E, Barnes, P J, Singh, D, Whyte, M K B & Dockrell, D H 2018, ' Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.201705-0903OC
Bewley, M A, Budd, R C, Ryan, E, Cole, J, Collini, P, Marshall, J, Kolsum, U, Beech, G, Emes, R D, Tcherniaeva, I, Berbers, G A M, Walmsley, S R, Donaldson, G, Wedzicha, J A, Kilty, I, Rumsey, W, Sanchez, Y, Brightling, C, Donnelly, L E, Barnes, P J, Singh, D, Whyte, M K B & Dockrell, D H 2018, ' Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.201705-0903OC
Rationale: Previous studies have identified defects in bacterial phagocytosis by alveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD), but the mechanisms and clinical consequences remain incompletely defined.Object
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ede7f3b1e46ae120abd9a1e44f2fc73
https://www.pure.ed.ac.uk/ws/files/67945656/AJRCCM_Online_Sup_TEXT_SUB.docx
https://www.pure.ed.ac.uk/ws/files/67945656/AJRCCM_Online_Sup_TEXT_SUB.docx
Autor:
David H. Dockrell, Richard C. Budd, PA Reid, G Choudhury, Eilise M. Ryan, William L. Rumsey, Yolanda Sanchez, Patrícia Coelho, Sarah R. Walmsley, Martin A. Bewley, MK Whyte
Publikováno v:
Mechanistic insights into COPD.
COPD patients have defective innate immunity, characterised in part by macrophage dysfunction. In established disease, both monocyte derived macrophages (MDM) and alveolar macrophages (AM), have impaired phagocytosis of bacteria and apoptotic cells (
Publikováno v:
Inflammation-From Molecular and Cellular Mechanisms to the Clinic ISBN: 9783527692156
Inflammation
Inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c82856499c13611a8d349eae2333f0f7
https://doi.org/10.1002/9783527692156.ch36
https://doi.org/10.1002/9783527692156.ch36
Autor:
Cormac T. Taylor, Bart Ghesquière, Massimilliano Mazzone, Helen M. Marriott, Veronica Moral, Patrick H. Maxwell, Eilise M. Ryan, Peter Carmeliet, Fiona Murphy, Joseph A Willson, David H. Dockrell, Amy Lewis, Rebecca S. Dickinson, Sarah R. Walmsley, Emily R. Watts, Martin Schneider, A. A. Roger Thompson, Pranvera Sadiku, Christopher W. Pugh, Ananda S. Mirchandani, Christopher J. Schofield, Peter J. Ratcliffe, Edwin R. Chilvers, Alison Harris, Moira K. B. Whyte, David Sammut
Publikováno v:
Sadiku, P, Willson, J A, Dickinson, R, Murphy, F, Harris, A, Lewis, A, Sammut, D, Mirchandani, A S, Ryan, E, Watts, E R, Thompson, A A R, Marriott, H M, Dockrell, D H, Taylor, C T, Schneider, M, Maxwell, P H, Chilvers, E R, Mazzone, M, Moral, V, Pugh, C W, Ratcliffe, P J, Schofield, C J, Ghesquiere, B, Carmeliet, P, Whyte, M K B & Walmsley, S R 2017, ' Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses ', Journal of Clinical Investigation, vol. 127, no. 9, pp. 3407-3420 . https://doi.org/10.1172/JCI90848
The Journal of Clinical Investigation
The Journal of Clinical Investigation
Fully activated innate immune cells are required for effective responses to infection, but their prompt deactivation and removal are essential for limiting tissue damage. Here, we have identified a critical role for the prolyl hydroxylase enzyme Phd2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba6dd30a163120cecfccb56afb32bb9
https://lirias.kuleuven.be/handle/123456789/668098
https://lirias.kuleuven.be/handle/123456789/668098