Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Eileen Socher"'
Autor:
Manfred Marschall, Martin Schütz, Markus Wild, Eileen Socher, Christina Wangen, Kishore Dhotre, William D. Rawlinson, Heinrich Sticht
Publikováno v:
Cells, Vol 13, Iss 16, p 1338 (2024)
Herpesviral protein kinases, such as the therapy-relevant pUL97 of human cytomegalovirus (HCMV), are important for viral replication efficiency as well as pathogenesis, and represent key antiviral drug targets. HCMV pUL97 is a viral cyclin-dependent
Externí odkaz:
https://doaj.org/article/701343dc21c342d0b556c8f8649ac032
Autor:
Sophie Gleixner, Ingrid Zahn, Jana Dietrich, Swati Singh, Alice Drobny, Yanni Schneider, Raphael Schwendner, Eileen Socher, Nicolas Blavet, Lars Bräuer, Antoniu-Oreste Gostian, Matthias Balk, Gundula Schulze-Tanzil, Claudia Günther, Friedrich Paulsen, Philipp Arnold
Publikováno v:
Cells, Vol 13, Iss 7, p 622 (2024)
The lacrimal gland is crucial for maintaining ocular health by producing the aqueous component of the tear film, which hydrates and nourishes the ocular surface. Decreased production of this component results in dry eye disease, a condition affecting
Externí odkaz:
https://doaj.org/article/88b7efdb51874476983b6c072ca1a25a
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1168-1176 (2022)
SARS-CoV-2, the virus causing the COVID-19 pandemic, changes frequently through the appearance of mutations constantly leading to new variants. However, only few variants evolve as dominating and will be considered as “Variants of Concern” (VOCs)
Externí odkaz:
https://doaj.org/article/71865dce21bf46b0a3a2487c4b61ff33
Autor:
Julia Tillmanns, Sigrun Häge, Eva Maria Borst, Julia Wardin, Jan Eickhoff, Bert Klebl, Sabrina Wagner, Christina Wangen, Friedrich Hahn, Eileen Socher, Manfred Marschall
Publikováno v:
Cells, Vol 12, Iss 8, p 1162 (2023)
Herpesviral nuclear egress is a regulated process of viral capsid nucleocytoplasmic release. Due to the large capsid size, a regular transport via the nuclear pores is unfeasible, so that a multistage-regulated export pathway through the nuclear lami
Externí odkaz:
https://doaj.org/article/b8e09ac0be3d4d7183c73416683f4922
Autor:
Martin Schütz, Regina Müller, Eileen Socher, Christina Wangen, Florian Full, Emanuel Wyler, Diana Wong, Myriam Scherer, Thomas Stamminger, Sunwen Chou, William D. Rawlinson, Stuart T. Hamilton, Heinrich Sticht, Manfred Marschall
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11814 (2022)
The complex host interaction network of human cytomegalovirus (HCMV) involves the regulatory protein kinase pUL97, which represents a viral cyclin-dependent kinase (CDK) ortholog. pUL97 interacts with the three human cyclin types T1, H, and B1, where
Externí odkaz:
https://doaj.org/article/1e8fe2e70fcc4f7a8d7709274b08ee92
Autor:
Antonia Sophia Peter, Eva Grüner, Eileen Socher, Kirsten Fraedrich, Elie Richel, Sandra Mueller-Schmucker, Arne Cordsmeier, Armin Ensser, Heinrich Sticht, Klaus Überla
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8177 (2022)
Mutations in the spike protein of SARS-CoV-2 can lead to evasion from neutralizing antibodies and affect the efficacy of passive and active immunization strategies. Immunization of mice harboring an entire set of human immunoglobulin variable region
Externí odkaz:
https://doaj.org/article/0c4fde1440b1458d8f56a95fed06420b
Autor:
Jessica Feldt, Martin Schicht, Jessica Welss, Kolja Gelse, Stefan Sesselmann, Michael Tsokos, Eileen Socher, Fabian Garreis, Thomas Müller, Friedrich Paulsen
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 723 (2022)
Gelsolin (GSN) is an actin-binding protein involved in cell formation, metabolism and wound closure processes. Since this protein is known to play a role in arthritis, here we investigate how the synovial membrane with its specific synoviocytes contr
Externí odkaz:
https://doaj.org/article/d92a7dffee5a4ba1b2ff2c1c63c6a5ee
Autor:
Norbert Donhauser, Eileen Socher, Sebastian Millen, Stefanie Heym, Heinrich Sticht, Andrea K Thoma-Kress
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008879 (2020)
The Human T-cell leukemia virus type 1 (HTLV-1) orf I-encoded accessory protein p8 is cleaved from its precursor p12, and both proteins contribute to viral persistence. p8 induces cellular protrusions, which are thought to facilitate transfer of p8 t
Externí odkaz:
https://doaj.org/article/3d3893a7d7e44d7bafa0f4210b4b94f4
Autor:
Martin Schütz, Mirjam Steingruber, Eileen Socher, Regina Müller, Sabrina Wagner, Merle Kögel, Heinrich Sticht, Manfred Marschall
Publikováno v:
Viruses, Vol 13, Iss 7, p 1248 (2021)
The replication of human cytomegalovirus (HCMV) is characterized by a complex network of virus–host interaction. This involves the regulatory viral protein kinase pUL97, which represents a viral cyclin-dependent kinase ortholog (vCDK) combining typ
Externí odkaz:
https://doaj.org/article/06c295cbe2084011ab3a5964db0c3a45
Autor:
Eileen Socher, Marcus Conrad, Lukas Heger, Friedrich Paulsen, Heinrich Sticht, Friederike Zunke, Philipp Arnold
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 525 (2021)
The B.1.1.7 variant of the SARS-CoV-2 virus shows enhanced infectiousness over the wild type virus, leading to increasing patient numbers in affected areas. Amino acid exchanges within the SARS-CoV-2 spike protein variant of B.1.1.7 affect inter-mono
Externí odkaz:
https://doaj.org/article/fbeeb2024bee443f9c13cc3d4a72b75c