Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Eileen Snowden"'
Autor:
Noora Nykänen, Rami Mäkelä, Antti Arjonen, Ville Härmä, Laura Lewandowski, Eileen Snowden, Rainer Blaesius, Ismo Jantunen, Teijo Kuopio, Juha Kononen, Juha K. Rantala
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The purpose of ex vivo drug screening in the context of precision oncology is to serve as a functional diagnostic method for therapy efficacy modeling directly on patient-derived tumor cells. Here, we report a case study using integrated multiomics e
Externí odkaz:
https://doaj.org/article/64c466555b9440d99ca2297d9bc90351
Autor:
Warren Porter, Eileen Snowden, Friedrich Hahn, Mitchell Ferguson, Frances Tong, W Shannon Dillmore, Rainer Blaesius
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238594 (2020)
Intratumor Heterogeneity (ITH) is a functionally important property of tumor tissue and may be involved in drug resistance mechanisms. Although descriptions of ITH can be traced back to very early reports about cancer tissue, mechanistic investigatio
Externí odkaz:
https://doaj.org/article/6998209b486841de813224e372d306c5
Autor:
Rainer Blaesius, W. Shannon Dillmore, Smita Ghanekar, Aaron Middlebrook, Joel S. Parker, Frances Tong, Mitchell Ferguson, Friedrich Hahn, Warren Porter, Eileen Snowden
Cell sorting strategy, Pathway maps for differentially expressed genes, Differentially expressed surface markers, AXL gene set used in analysis. Figure S1: Staining and gating strategy of flow cytometry analysis. Figure S2: Sorting strategy to isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fff04ae572ab78513879ec85def43a9
https://doi.org/10.1158/1541-7786.22511208
https://doi.org/10.1158/1541-7786.22511208
Autor:
Mitchell Ferguson, Friedrich Hahn, Hiroshi Nakagawa, Erica L. Carpenter, Michael L. Kochman, Gary W. Falk, Anil K. Rustgi, Stephanie S. Yee, Moen Sen, Emylee N. Fleshman, Maureen DeMarshall, Taylor A. Black, Frances Tong, Warren Porter, Gregory G. Ginsberg, Rainer Blaesius, Eileen Snowden
Publikováno v:
Oncotarget
Barrett's esophagus (BE) is metaplasia of the squamous epithelium to a specialized columnar epithelium. BE progresses through low- and high-grade dysplasia before developing into esophageal adenocarcinoma. The BE microenvironment is not well defined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97ab077a2599ff593d03277a5504e26
http://europepmc.org/articles/PMC6557213
http://europepmc.org/articles/PMC6557213
Autor:
Hye-Won Song, Elham Hatami, Samatha Vadrevu, Jody Martin, Eileen Snowden, Timothy Zheng Zhu, Adam Wright, Margaret Nakamoto, Shannon Dillmore, Aruna Ayer
Publikováno v:
The Journal of Immunology. 208:173.04-173.04
DNA-barcoded antibodies enable single-cell multiomics approaches that examine protein alongside mRNA in a single cell. Although it is a powerful approach, leading methods are currently limited to surface proteins, which limits understanding of signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e5cfb9009c003705d32b58a40b4c535
https://doi.org/10.4049/jimmunol.208.supp.173.04
https://doi.org/10.4049/jimmunol.208.supp.173.04
Autor:
Friedrich Hahn, Frances Tong, W Shannon Dillmore, Mitchell Ferguson, Warren Porter, Eileen Snowden, Rainer Blaesius
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238594 (2020)
PLoS ONE, Vol 15, Iss 9, p e0238594 (2020)
Intratumor Heterogeneity (ITH) is a functionally important property of tumor tissue and may be involved in drug resistance mechanisms. Although descriptions of ITH can be traced back to very early reports about cancer tissue, mechanistic investigatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66eaa7354e667edc2b59407342193230
https://doi.org/10.1371/journal.pone.0238594
https://doi.org/10.1371/journal.pone.0238594
Autor:
Eileen Snowden, Friedrich Hahn, Frances Tong, Mitchell Ferguson, Warren Porter, Smita Ghanekar, Aaron Middlebrook, Rainer Blaesius, Joel S. Parker, W Shannon Dillmore
Cancer tissue functions as an ecosystem of a diverse set of cells that interact in a complex tumor microenvironment. Genomic tools applied to biopsies in bulk fail to account for this tumor heterogeneity, whereas single-cell imaging methods limit the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5caccb64f80ceef9ad0ef24c3be2b784
Autor:
William S. Dillmore, Rainer Blaesius, Frances Tong, Mitchell Ferguson, Hong Zhang, Warren Porter, Friedrich Hahn, Eileen Snowden, Anderson Clark
Publikováno v:
Cancer Research. 79:4710-4710
Small Cell Lung Cancer (SCLC) is characterized by rapid tumor growth and currently, there are few therapeutic options or predictive biomarkers. Patient derived xenograft (PDX) models are capable of recapitulating solid tumor growth including the intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4297bdf8016ec1c3e716137ceeaa16b1
https://doi.org/10.1158/1538-7445.am2019-4710
https://doi.org/10.1158/1538-7445.am2019-4710
Autor:
Daniel Ditzel Santos, Aaron Middlebrook, Friedrich Hahn, Mitchell Ferguson, Warren Porter, Caitlin Austin, Eileen Snowden, Rainer Blaesius, Smita Ghanekar
Publikováno v:
Cancer Research. 78:2113-2113
The heterogeneous nature of solid tumors, coupled with the relatively small sample size of available biopsies, has led to an emerging need to glean as much information as possible from these valuable specimens. Current approaches to solid tumor analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc02484759f1bcf212ba9c56db8340fa
https://doi.org/10.1158/1538-7445.am2018-2113
https://doi.org/10.1158/1538-7445.am2018-2113
Autor:
William S. Dillmore, Rainer Blaesius, Hong Zhang, Mitchell Ferguson, Eileen Snowden, Warren Porter, Anderson Clark, Frances Tong, Friedrich Hahn
Publikováno v:
Cancer Research. 78:2197-2197
Small Cell Lung Cancer (SCLC) is characterized by rapid tumor growth and currently, there are few therapeutic options. As part of the development of M2698, a potent, selective inhibitor of p70S6K and AKT 1/3, the compound was tested in a preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fda37cf5dfb15652c59be3480969d34
https://doi.org/10.1158/1538-7445.am2018-2197
https://doi.org/10.1158/1538-7445.am2018-2197