Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Eileen S. Chow"'
Publikováno v:
Neurobiology of Disease, Vol 192, Iss , Pp 106429- (2024)
The most prominent symptom of Alzheimer's disease (AD) is cognitive decline; however, sleep and other circadian disruptions are also common in AD patients. Sleep disruptions have been connected with memory problems and therefore the changes in sleep
Externí odkaz:
https://doaj.org/article/fdc3fa36063345fea0e5bb800225068b
Autor:
Alexander D. Law, Marlène Cassar, Dani M. Long, Eileen S. Chow, Jadwiga M. Giebultowicz, Anjana Venkataramanan, Roland Strauss, Doris Kretzschmar
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105770- (2022)
Although mutations in the microtubules-associated protein Tau have long been connected with several neurodegenerative diseases, the underlying molecular mechanisms causing these tauopathies are still not fully understood. Studies in various models su
Externí odkaz:
https://doaj.org/article/5662c98be9934fca882e7065b3adf1e7
Autor:
Trevor R. Nash, Eileen S. Chow, Alexander D. Law, Samuel D. Fu, Elzbieta Fuszara, Aleksandra Bilska, Piotr Bebas, Doris Kretzschmar, Jadwiga M. Giebultowicz
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 5, Iss 1, Pp 1-8 (2019)
Abstract Light is necessary for life, but prolonged exposure to artificial light is a matter of increasing health concern. Humans are exposed to increased amounts of light in the blue spectrum produced by light-emitting diodes (LEDs), which can inter
Externí odkaz:
https://doaj.org/article/b5a13df9da704333ac49a61936553663
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
A hallmark feature of Alzheimer’s disease (AD) and other Tauopathies, like Frontotemporal Dementia with Parkinsonism linked to chromosome 17 (FTDP-17), is the accumulation of neurofibrillary tangles composed of the microtubule-associated protein Ta
Externí odkaz:
https://doaj.org/article/6b32aeac766e4116acc3e5210b2b4f86
Autor:
Rachael C. Kuintzle, Eileen S. Chow, Tara N. Westby, Barbara O. Gvakharia, Jadwiga M. Giebultowicz, David A Hendrix
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Disruption of circadian rhythms leads to reduced healthspan, but the mechanisms by which the normal clock protects aging organisms are not known. Here, the authors show that a subset of genes becomes more rhythmically expressed in older flies, and th
Externí odkaz:
https://doaj.org/article/72d2f017cdf647a7826f0fc41de1759f
Autor:
Matthew R. Blake, Scott D. Holbrook, Joanna Kotwica-Rolinska, Eileen S. Chow, Doris Kretzschmar, Jadwiga M. Giebultowicz
Publikováno v:
Neurobiology of Disease, Vol 77, Iss , Pp 117-126 (2015)
Alzheimer's disease (AD) is a neurodegenerative disease characterized by severe cognitive deterioration. While causes of AD pathology are debated, a large body of evidence suggests that increased cleavage of Amyloid Precursor Protein (APP) producing
Externí odkaz:
https://doaj.org/article/a6290416fee14b209f00b2a63e95b552
Autor:
Natraj Krishnan, Kuntol Rakshit, Eileen S. Chow, Jill S. Wentzell, Doris Kretzschmar, Jadwiga M. Giebultowicz
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 1129-1135 (2012)
Circadian clocks generate rhythms in molecular, cellular, physiological, and behavioral processes. Recent studies suggest that disruption of the clock mechanism accelerates organismal senescence and age-related pathologies in mammals. Impaired circad
Externí odkaz:
https://doaj.org/article/0ac48a79343d4cfe83238c5b629d010f
Autor:
Vladimir I. Klichko, Eileen S. Chow, Joanna eKotwica-Rolinska, William C. Orr, Jadwiga Maria Giebultowicz, Svetlana N. Radyuk
Publikováno v:
Frontiers in Genetics, Vol 6 (2015)
Circadian coordination of metabolism, physiology and neural functions contributes to healthy aging and disease prevention. Clock genes govern the daily rhythmic expression of target genes whose activities underlie such broad physiological parameters
Externí odkaz:
https://doaj.org/article/83c6dcc9822742bba14b7e2092b70095
Autor:
Benjamin Sebastian, Rosalyn M. Fey, Patrick Morar, Brittany Lasher, Eileen S. Chow, Jadwiga M. Geibultowicz, David A. Hendrix
Many critical life processes are regulated by input from 24-hour external light/dark cycles, such as metabolism, cellular homeostasis, and detoxification. The circadian clock, which helps coordinate the response to these diurnal light/dark cycles, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af3696e7dbe18ecc95fe30eeb407dbf
https://doi.org/10.1101/2022.04.06.487011
https://doi.org/10.1101/2022.04.06.487011
Autor:
Rosalyn M. Fey, Eileen S. Chow, Barbara O. Gvakharia, Jadwiga M. Giebultowicz, David A. Hendrix
Publikováno v:
F1000Research. 11:1543
Background: MicroRNAs are a class of small (~22nt) endogenous RNAs that regulate target transcript expression post-transcriptionally. Previous studies characterized age-related changes in diurnal transcript expression but it is not understood how the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56c34958397b0abc29779226baa9f26f
https://doi.org/10.12688/f1000research.124724.1
https://doi.org/10.12688/f1000research.124724.1