Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Eileen Remold‐O′Donnell"'
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3444 (2008)
Population level evolutionary processes can occur within a single organism when the germ line contains a mutation that confers a cost at the level of the cell. Here we describe how multiple compensatory mutations arose through a within-individual evo
Externí odkaz:
https://doaj.org/article/b16e598cf7d441f989dfd1f017262af1
Autor:
Jessica Cooley, Dion Kaiserman, Lifei Hou, Phillip I. Bird, Koichi Yuki, Peter A. Nigrovic, Lauren A. Henderson, Burkhard Becher, Mark P. Gorman, A. Helena Jonsson, Deepak A. Rao, Eileen Remold-O'Donnell
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(41)
Significance The study addresses a basic immunology topic with considerable clinical relevance, namely the nature of the pathogenic T helper cells that drive autoimmune disorders like multiple sclerosis (MS) and inflammatory arthritis. Using mouse MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e2bab9b23f9aa7365c6e8d18193364
https://pubmed.ncbi.nlm.nih.gov/31548399
https://pubmed.ncbi.nlm.nih.gov/31548399
Autor:
Maureen Gallant, Kimberly Martinod, Thilo Witsch, Kalamo Farley, Eileen Remold-O'Donnell, Denisa D. Wagner
Publikováno v:
Journal of Thrombosis and Haemostasis. 14:551-558
UNLABELLED ESSENTIALS: Neutrophil elastase (NE) plays a role in extracellular trap formation (NETosis) triggered by microbes. The contribution of NE was evaluated in mouse NETosis models of sterile inflammation and thrombosis. NE is not required for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c611467d0132438875dd5e7490147c35
https://doi.org/10.1111/jth.13239
https://doi.org/10.1111/jth.13239
Autor:
Mathias Baumann, Paola Basilico, Ivo P. Touw, Charaf Benarafa, Sabrina Sofia Burgener, Eileen Remold-O'Donnell
Publikováno v:
Burgener, Sabrina; Baumann, Mathias; Basilico, Paola; Remold-O'Donnell, Eileen; Touw, Ivo P; Benarafa, Charaf (2016). Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1. Biological chemistry, 397(9), pp. 897-905. De Gruyter 10.1515/hsz-2016-0132
Biological Chemistry, 397(9), 897-905. De Gruyter
Biological Chemistry, 397(9), 897-905. De Gruyter
Serpinb1 is an inhibitor of neutrophil granule serine proteases cathepsin G, proteinase-3 and elastase. One of its core physiological functions is to protect neutrophils from granule protease-mediated cell death. Mice lacking Serpinb1a (Sb1a -/-), it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0444da18b278b25a481767390141e2b1
https://doi.org/10.1515/hsz-2016-0132
https://doi.org/10.1515/hsz-2016-0132
Autor:
Jiaxi Zhou, Peng Liu, Shannan Cao, Anongnard Kasorn, Haiyan Gong, Yuanfu Xu, Dieter E. Jenne, Keqiang Ye, Hongbo R. Luo, Fabien Loison, Eileen Remold-O'Donnell, Kutay Karatepe, Haiyan Zhu
Publikováno v:
Journal of Clinical Investigation. 124:4445-4458
Caspase-3–mediated spontaneous death in neutrophils is a prototype of programmed cell death and is critical for modulating physiopathological inflammatory responses; however, the underlying regulatory pathways remain ill defined. Here we determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0f461b457071409e8daa3178d9a131
https://doi.org/10.1172/jci76246
https://doi.org/10.1172/jci76246
Publikováno v:
Journal of Leukocyte Biology. 95:521-530
SerpinB1 is an endogenous inhibitor of serine proteases recognized for its anti-inflammatory and host-protective properties. Although loss of serpinB1 in mice does not result in gross immune deregulation, serpinb1a−/− mice display increased morta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67823a72a91f73dd749b24628444344
https://doi.org/10.1189/jlb.0613331
https://doi.org/10.1189/jlb.0613331
Autor:
Charaf Benarafa, Mitchell R. White, Dapeng Gong, Eileen Remold-O'Donnell, Kevan L. Hartshorn, Kalamo Farley
Publikováno v:
The Journal of infectious diseases
The serine proteases elastase, cathepsin G, and proteinase-3 are increasingly recognized as modulators of inflammation (reviewed in [1]). These enzymes, commonly called neutrophil serine proteases (NSPs), enter the lungs of infected mice as component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb00bb0465b1109200632d9c4154db5a
http://www.atsjournals.org/doi/full/10.1165/rcmb.2012-0145OC
http://www.atsjournals.org/doi/full/10.1165/rcmb.2012-0145OC
Autor:
Katherine Larabee, Jonathan S. Coblyn, Elena Massarotti, Gerald F. Watts, Peter A. Nigrovic, Richard W. Farndale, Eric Boilard, David M. Lee, Jerry Ware, Eileen Remold-O'Donnell, Michael E. Weinblatt
Publikováno v:
Science. 327:580-583
Platelet Microparticles Drive Inflammatory Arthritis Platelets are best known for their critical role in blood clot formation during wound repair, but an appreciation for their role in inflammatory processes is growing. Platelet-derived cellular micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470f99fdfa79dca37fbc55b4a878e1e7
https://doi.org/10.1126/science.1181928
https://doi.org/10.1126/science.1181928
Publikováno v:
Journal of Leukocyte Biology. 83:946-955
The manuscript presents definitive studies of surfactant protein D (SP-D) in the con- text of inflammatory lung fluids. The extent of SP-D depletion in bronchoalveolar lavage fluid (BALF) of children affected with cystic fibrosis (CF) is demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e1bc06c4fd1613383215ead0a4befe
https://doi.org/10.1189/jlb.1007684
https://doi.org/10.1189/jlb.1007684
Publikováno v:
The Journal of Experimental Medicine
Neutrophil serine proteases (NSPs; elastase, cathepsin G, and proteinase-3) directly kill invading microbes. However, excess NSPs in the lungs play a central role in the pathology of inflammatory pulmonary disease. We show that serpinb1, an efficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bbeb1dd79b37fb51cdeebe66977899
http://europepmc.org/articles/PMC2118684
http://europepmc.org/articles/PMC2118684