Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Eileen McNeill"'
Publikováno v:
Cells, Vol 13, Iss 11, p 916 (2024)
Acute inflammation is a rapid and dynamic process involving the recruitment and activation of multiple cell types in a coordinated and precise manner. Here, we investigate the origin and transcriptional reprogramming of monocytes using a model of acu
Externí odkaz:
https://doaj.org/article/e62c6d9c98204d12b01a2a8f4ddda00c
Autor:
Sabrina Sailer, Stefan Coassin, Katharina Lackner, Caroline Fischer, Eileen McNeill, Gertraud Streiter, Christian Kremser, Manuel Maglione, Catherine M. Green, Daniela Moralli, Alexander R. Moschen, Markus A. Keller, Georg Golderer, Gabriele Werner-Felmayer, Irmgard Tegeder, Keith M. Channon, Benjamin Davies, Ernst R. Werner, Katrin Watschinger
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Background Genome editing in mice using either classical approaches like homologous recombination or CRISPR/Cas9 has been reported to harbor off target effects (insertion/deletion, frame shifts or gene segment duplications) that lead to muta
Externí odkaz:
https://doaj.org/article/8ea297638f64458d935a9b1e4923a4b5
Autor:
Eileen McNeill, Elena Stylianou, Mark J. Crabtree, Rachel Harrington-Kandt, Anna-Lena Kolb, Marina Diotallevi, Ashley B. Hale, Paulo Bettencourt, Rachel Tanner, Matthew K. O’Shea, Magali Matsumiya, Helen Lockstone, Julius Müller, Helen A. Fletcher, David R. Greaves, Helen McShane, Keith M. Channon
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Inducible nitric oxide (NO) synthase (iNOS) is essential in the response to mycobacterial infection, yet NOS signalling can occur through NO-dependent or NO-independent pathways. Here the authors show macrophage Gch1 and tetrahydrobiopterin mediate N
Externí odkaz:
https://doaj.org/article/6b10bf22d1cf44e59fc4465f802a33e8
Autor:
Jade D. Bailey, Marina Diotallevi, Thomas Nicol, Eileen McNeill, Andrew Shaw, Surawee Chuaiphichai, Ashley Hale, Anna Starr, Manasi Nandi, Elena Stylianou, Helen McShane, Simon Davis, Roman Fischer, Benedikt M. Kessler, James McCullagh, Keith M. Channon, Mark J. Crabtree
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 218-230.e7 (2019)
Summary: Classical activation of macrophages (M(LPS+IFNγ)) elicits the expression of inducible nitric oxide synthase (iNOS), generating large amounts of NO and inhibiting mitochondrial respiration. Upregulation of glycolysis and a disrupted tricarbo
Externí odkaz:
https://doaj.org/article/cc2fff285c5a45c9a7e1583fa7e6da7b
Autor:
Christakis Constantinides, Mahon Maguire, Eileen McNeill, Ricardo Carnicer, Edyta Swider, Mangala Srinivas, Carolyn A Carr, Jurgen E Schneider
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225786 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0190558.].
Externí odkaz:
https://doaj.org/article/2d55bff9fda94ee6b308151b567dd62f
Autor:
Christakis Constantinides, Mahon Maguire, Eileen McNeill, Ricardo Carnicer, Edyta Swider, Mangala Srinivas, Carolyn A Carr, Jurgen E Schneider
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190558 (2018)
PurposeTo a) achieve cardiac 19F-Magnetic Resonance Imaging (MRI) of perfluoro-crown-ether (PFCE) labeled cardiac progenitor stem cells (CPCs) and bone-derived bone marrow macrophages, b) determine label concentration and cellular load limits, and c)
Externí odkaz:
https://doaj.org/article/e5b276cbc9484c30a323c2f421bc712f
Autor:
Asif J Iqbal, Tessa J Barrett, Lewis Taylor, Eileen McNeill, Arun Manmadhan, Carlota Recio, Alfredo Carmineri, Maximillian H Brodermann, Gemma E White, Dianne Cooper, Joseph A DiDonato, Maryam Zamanian-Daryoush, Stanley L Hazen, Keith M Channon, David R Greaves, Edward A Fisher
Publikováno v:
eLife, Vol 5 (2016)
Apolipoprotein A1 (apoA1) is the major protein component of high-density lipoprotein (HDL) and has well documented anti-inflammatory properties. To better understand the cellular and molecular basis of the anti-inflammatory actions of apoA1, we explo
Externí odkaz:
https://doaj.org/article/4f6ab8947a3d4308a252fadfcd67c3a6
Autor:
Asif J Iqbal, Daniel Regan-Komito, Ivy Christou, Gemma E White, Eileen McNeill, Amy Kenyon, Lewis Taylor, Theodore S Kapellos, Edward A Fisher, Keith M Channon, David R Greaves
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58744 (2013)
Chemotaxis assays are an invaluable tool for studying the biological activity of inflammatory mediators such as CC chemokines, which have been implicated in a wide range of chronic inflammatory diseases. Conventional chemotaxis systems such as the mo
Externí odkaz:
https://doaj.org/article/fce6674479494768832c2d37a8acafe2
Publikováno v:
Mediators of Inflammation, Vol 2013 (2013)
Heterotrimeric G-protein-coupled receptors (GPCRs) are key mediators of intracellular signalling, control numerous physiological processes, and are one of the largest class of proteins to be pharmacologically targeted. Chemokine-induced macrophage re
Externí odkaz:
https://doaj.org/article/8f3e4c3c86f04f5eb6ea60ce69ebd394
Autor:
Mark J. Crabtree, Keith M. Channon, Ben Davies, Eileen McNeill, Andrew Shaw, Jade Bailey, Faseeha Ayaz, Thomas Nicol, Marina Diotallevi
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9583d92e9810b18bbd945b1a7044f8
https://doi.org/10.3791/62834
https://doi.org/10.3791/62834