Výsledky vyhledávání - "Eileen M Mcmillan"

Analysis of procoagulant phosphatidylserine‐exposing platelets by imaging flow cytometry

Autor: Hilary Christensen, Emily C. Reddy, Hong Wang, Eileen M. McMillan-Ward, Sara J. Israels, Margaret L. Rand, K. W. Annie Bang

Publikováno v: Research and Practice in Thrombosis and Haemostasis

Background Upon platelet activation, a subpopulation of procoagulant platelets is formed, characterized by the exposure of the anionic aminophospholipid phosphatidylserine (PS) on the surface membrane. Objective To evaluate procoagulant PS-exposing p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f39682b8f5a685990671540f7e0e4ab
http://europepmc.org/articles/PMC6178738

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IL-4 Mediated Upregulation of AMPK/SIRT1/PGC-1α Signalling Pathway Is Bypassed By Mitochondrial Complex I Downregulation By NAMPT Inhibition in Venetoclax and Ibrutinib Treated CLL Cells

Autor: James A. Thliveris, Sara J. Israels, Spencer B. Gibson, Tricia R. Choquette, Versha Banerji, James B. Johnston, Amandeep Singh, Edwin Nguyen, Eileen M. McMillan-Ward, Eric D.J. Bouchard, Cheryl Peltier, Ryan Saleh, Subir K. Roy Chowdhury, Kira Peters, Maxim Skorodinsky, Aaron J. Marshall

Publikováno v: Blood. 138:2616-2616

Introduction: Chronic lymphocytic leukemia (CLL) is one of the most common types of leukemia in adults. Despite significant improvement in the treatment of CLL, drug resistance is emerging when using the single agents ibrutinib or venetoclax. To achi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b019a745e0fb326e8ccb64524d31b63d
https://doi.org/10.1182/blood-2021-146947

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Tyrosine kinase receptor EGFR regulates the switch in cancer cells between cell survival and cell death induced by autophagy in hypoxia

Autor: Sara J. Israels, Daniel Huang, Spencer B. Gibson, Yongqiang Chen, Wenyan Xiao, Elizabeth S. Henson, Eileen M. McMillan-Ward

Publikováno v: Autophagy. 12:1029-1046

Autophagy is an intracellular lysosomal degradation pathway where its primary function is to allow cells to survive under stressful conditions. Autophagy is, however, a double-edge sword that can either promote cell survival or cell death. In cancer,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9c150fa9ac9e0746a9d024719d1f4d
https://doi.org/10.1080/15548627.2016.1164357

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Comparison of light transmission aggregometry and multiple electrode aggregometry for the evaluation of patients with mucocutaneous bleeding

Autor: Ping Sun, Rajibul Mian, Eileen M. McMillan-Ward, Sara J. Israels

Publikováno v: International journal of laboratory hematology. 41(1)

Introduction The "gold standard" diagnostic test for assessing in vitro platelet function, light transmission aggregometry (LTA), has limitations to application because of sample requirements. Whole blood or multiple electrode aggregometry (MEA) usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea88ca23804fbe594f048e6558779b8
https://pubmed.ncbi.nlm.nih.gov/30358923

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Abstract 3515: Down the rabbit hole with structural effects of FK866 in primary CLL B cells

Autor: Iris Gehrke, Spencer B. Gibson, Sara J. Israels, Eileen M. McMillan-Ward, Nabanita Chatterje, Cheryl Peltier, Versha Banerji, Shantanu Banerji, Cornelia N. Mutz, Eric D. J. Bouchard, Elizabeth S. Henson, Heinrich Kovar, Donna Hewitt, Matthieu Bourrier, Danielle Desautels

Publikováno v: Cancer Research. 78:3515-3515

FK866 (Daporinad or APO866) is a specific inhibitor of NAMPT (nicotinamide phosphoribosyltransferase), a rate limiting enzyme involved in NAD generation. It is a prospective cancer treatment utilized in several clinical trials and has generated much

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b364d63849054c21ed38ef2f29c330ee
https://doi.org/10.1158/1538-7445.am2018-3515

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Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species

Autor: Yongqiang Chen, Spencer B. Gibson, Jiming Kong, Eileen M. McMillan-Ward, Sara J. Israels

Publikováno v: Journal of Cell Science. 120:4155-4166

Autophagy is a self-digestion process important for cell survival during starvation. It has also been described as a form of programmed cell death. Mitochondria are important regulators of autophagy-induced cell death and damaged mitochondria are oft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b637ab718de6a03ec51922a5002cad65
https://doi.org/10.1242/jcs.011163

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Platelet tetraspanin complexes and their association with lipid rafts

Autor: Eileen M. McMillan-Ward, Sara J. Israels

Publikováno v: Thrombosis and Haemostasis. 98:1081-1087

SummaryTetraspanins are a superfamily of integral membrane proteins that facilitate the organization of membrane and intracellular signaling molecules into dynamic signaling microdomains, tetraspaninenriched microdomains (TEMs). Four tetraspanin fami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1665e94d1cf10761859641ab030dfe6d
https://doi.org/10.1160/th06-08-0455

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BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF

Autor: Spencer B. Gibson, Eileen M. McMillan-Ward, Michelle Bailes, Shilpa Kothari, Karen Ens, Lorrie A. Kirshenbaum, Sara J. Israels, Jeannick Cizeau

Publikováno v: Oncogene. 22:4734-4744

Hypoxic regions within solid tumors are often resistant to chemotherapy and radiation. BNIP3 (Bcl-2/E1B 19 kDa interacting protein) is a proapoptotic member of the Bcl-2 family that is expressed in hypoxic regions of tumors. During hypoxia, BNIP3 exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10f95bca00b8021cf7c6800ba31d799
https://doi.org/10.1038/sj.onc.1206666

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The ribonucleotide reductase R2 gene is a non-transcribed target of c-Myc-induced genomic instability

Autor: Sara J. Israels, Sabine Mai, Cheryl Taylor, Eileen M. McMillan-Ward, J. Frederic Mushinski, Darren W. Henderson, Theodore I. Kuschak, Jim A. Wright

Publikováno v: Gene. 238:351-365

The c-Myc oncoprotein is highly expressed in malignant cells of many cell types, but the mechanism by which it contributes to the transformation process is not fully understood. Here, we show for the first time that constitutive or activated overexpr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af42ebe25111eb084b23d64febbe53ce
https://doi.org/10.1016/s0378-1119(99)00341-8

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Deficient Thromboxane Synthesis and Response in Platelets from Premature Infants

Autor: Archibald McNicol, Felix S Odaibo, Catherine Robertson, Eileen M Mcmillan, Sara J. Israels

Publikováno v: Pediatric Research. 41:218-223

In vitro function of cord blood platelets from 35 premature infants (gestational age 32 +/- 3.2 wk) was compared with that of 12 full-term infants and 14 adult control subjects. In comparison with adult platelets, preterm platelets showed impaired ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e832dda893a6b7d22a8a063587cb0172
https://doi.org/10.1203/00006450-199702000-00011

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