Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Eileen F. Grady"'
Autor:
Eric Kubat, Shilpi Mahajan, Min Liao, Larry Ackerman, Peter T. Ohara, Eileen F. Grady, Aditi Bhargava
Publikováno v:
Molecular Medicine, Vol 19, Iss 1, Pp 212-222 (2013)
Abstract Although females suffer twice as much as males from stress-related disorders, sex-specific participating and pathogenic cellular stress mechanisms remain uncharacterized. Using corticotropin-releasing factor receptor 2-deficient (Crhr2−/
Externí odkaz:
https://doaj.org/article/fd163191ff1e4237ba989ab6c1e5ca92
Autor:
Maria Pini, Davina H Rhodes, Karla J Castellanos, Robert J Cabay, Eileen F Grady, Giamila Fantuzzi
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40944 (2012)
Obesity increases severity of acute pancreatitis (AP) by unclear mechanisms. We investigated the effect of the PPAR-gamma agonist rosiglitazone (RGZ, 0.01% in the diet) on severity of AP induced by administration of IL-12+ IL-18 in male C57BL6 mice f
Externí odkaz:
https://doaj.org/article/8259714e3a344adeaa5486fb122d12e0
Autor:
Susan E. Leeman, Matthew S. Clifton, Eileen F. Grady, Min Liao, Pallavi Mhaske, Charalabos Pothoulakis, Aditi Bhargava
Publikováno v:
Proceedings of the National Academy of Sciences. 110:731-736
Enteritis caused by Clostridium difficile toxin (Tx) is a nosocomial disease of increasing clinical concern, but the local mediators of C. difficile TxA inflammation are unknown. The potent vasodilator calcitonin gene-related peptide mediates neuroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf6f7aa5a29252e0309a76b924a2bec
https://doi.org/10.1073/pnas.1219733110
https://doi.org/10.1073/pnas.1219733110
Autor:
Rohini Chennuri, Giamila Fantuzzi, Karla J. Castellanos, Robert J. Cabay, Davina H. Rhodes, Maria Pini, Eileen F. Grady, Andrew R. Hall
Publikováno v:
Journal of Leukocyte Biology. 91:957-966
Obesity increases severity of acute pancreatitis and risk of pancreatic cancer. Pancreatitis and obesity are associated with elevated IL-6, a cytokine involved in inflammation and tumorigenesis. We studied the role of IL-6 in the response of lean and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9623e6fc326c99cb1ca554a30c43d94
https://doi.org/10.1189/jlb.1211627
https://doi.org/10.1189/jlb.1211627
Autor:
Wolfgang Liedtke, Eugene P. Ceppa, Fiore Cattaruzza, Kimberly S. Kirkwood, Victoria Lyo, Eileen F. Grady, Natalya Vaksman, Daniel P. Poole, Silvia Amadesi, Nigel W. Bunnett, Juan Carlos Pelayo, David M. Cohen
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 299:G556-G571
The mechanisms of pancreatic pain, a cardinal symptom of pancreatitis, are unknown. Proinflammatory agents that activate transient receptor potential (TRP) channels in nociceptive neurons can cause neurogenic inflammation and pain. We report a major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7d93281217b6b3d8e32a754fad4b11
https://doi.org/10.1152/ajpgi.00433.2009
https://doi.org/10.1152/ajpgi.00433.2009
Autor:
Gerald W. Zamponi, Nicolas Cenac, Christophe Altier, Pierangelo Geppetti, Eileen F. Grady, Nigel W. Bunnett, Wolfgang Liedtke, Serena Materazzi, Kevin Chapman, Fiore Cattaruzza, Laurie Cellars, Nathalie Vergnolle, Romina Nassini
Publikováno v:
British Journal of Pharmacology. 159:1161-1173
Background and purpose: Changes in extracellular fluid osmolarity, which occur after tissue damage and disease, cause inflammation and maintain chronic inflammatory states by unknown mechanisms. Here, we investigated whether the osmosensitive channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1ff9d792b7a8b5505526166fa1e9a56
https://doi.org/10.1111/j.1476-5381.2009.00590.x
https://doi.org/10.1111/j.1476-5381.2009.00590.x
Autor:
Ian Spreadbury, Nigel W. Bunnett, Marcela Miranda-Morales, Eileen F. Grady, Fiore Cattaruzza, Stephen Vanner
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 298:G81-G91
The excitatory ion channel transient receptor potential ankyrin-1 (TRPA1) is prominently expressed by primary afferent neurons and is a mediator of inflammatory pain. Inflammatory agents can directly activate [e.g., hydroxynonenal (HNE), prostaglandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da6cc638a38de3306ed61eee1dd49b0
https://doi.org/10.1152/ajpgi.00221.2009
https://doi.org/10.1152/ajpgi.00221.2009
Autor:
Orlando A. Pérez, Juan Carlos G. Marvizón, Nigel W. Bunnett, Bingbing Song, Eileen F. Grady, Andrew J. Todd, Wenling Chen
Publikováno v:
Neuroscience. 148:250-265
Calcitonin gene-related peptide (CGRP) is abundant in the central terminals of primary afferents. However, the function of CGRP receptors in the spinal cord remains unclear. CGRP receptors are heterodimers of calcitonin receptor-like receptor (CRLR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bee808c2061b5b476bb3bf1d488ed73
https://doi.org/10.1016/j.neuroscience.2007.05.036
https://doi.org/10.1016/j.neuroscience.2007.05.036
Autor:
Wolfgang Knecht, Paul J. Wolters, Brett R. Murphy, Stella Pikios, Eileen F. Grady, Charalabos Pothoulakis, Silvia Amadesi, Eric Camerer, George H. Caughey, Nigel W. Bunnett, J. Adam Willardsen, Graeme S. Cottrell, Shaun R. Coughlin, Anders Peterson
Publikováno v:
Gastroenterology. 132:2422-2437
Background & Aims: We studied the role of protease-activated receptor 2 (PAR2) and its activating enzymes, trypsins and tryptase, in Clostridium difficile toxin A (TxA)-induced enteritis. Methods: We injected TxA into ileal loops in PAR2 or dipeptidy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce7faaa60b1005cbb4afe479ee7ed7f0
https://doi.org/10.1053/j.gastro.2007.03.101
https://doi.org/10.1053/j.gastro.2007.03.101
Publikováno v:
Neuroscience. 144:1393-1408
Neurokinin-3 (NK 3 ) receptors are prevalent within the substantia nigra (SN) and ventral tegmental area (VTA), where their activation can affect motor and motivational behaviors as well as cardiovascular function and stress responses. These actions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8b8ad7f95550e295aa93c685e86551
https://doi.org/10.1016/j.neuroscience.2006.10.058
https://doi.org/10.1016/j.neuroscience.2006.10.058