Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Eileanoir B, Johnson"'
Autor:
Zhen-Yi Andy Ou, Lauren M. Byrne, Filipe B. Rodrigues, Rosanna Tortelli, Eileanoir B. Johnson, Martha S. Foiani, Marzena Arridge, Enrico De Vita, Rachael I. Scahill, Amanda Heslegrave, Henrik Zetterberg, Edward J. Wild
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Brain-derived neurotrophic factor (BDNF) is implicated in the survival of striatal neurons. BDNF function is reduced in Huntington’s disease (HD), possibly because mutant huntingtin impairs its cortico-striatal transport, contributing to s
Externí odkaz:
https://doaj.org/article/87c1ce7916eb411a90ed61e22ac22bba
Autor:
Paul Zeun, Peter McColgan, Thijs Dhollander, Sarah Gregory, Eileanoir B. Johnson, Marina Papoutsi, Akshay Nair, Rachael I. Scahill, Geraint Rees, Sarah J. Tabrizi
Publikováno v:
NeuroImage: Clinical, Vol 33, Iss , Pp 102927- (2022)
Objectives: To investigate the timeframe prior to symptom onset when cortico-basal ganglia white matter (white matter) loss begins in premanifest Huntington’s disease (preHD), and which striatal and thalamic sub-region white matter tracts are most
Externí odkaz:
https://doaj.org/article/fd0c448432f7454cb40720aa895efbbd
Autor:
Peter A. Wijeratne, Eileanoir B. Johnson, Sarah Gregory, Nellie Georgiou-Karistianis, Jane S. Paulsen, Rachael I. Scahill, Sarah J. Tabrizi, Daniel C. Alexander
Publikováno v:
Frontiers in Big Data, Vol 4 (2021)
Understanding the order and progression of change in biomarkers of neurodegeneration is essential to detect the effects of pharmacological interventions on these biomarkers. In Huntington’s disease (HD), motor, cognitive and MRI biomarkers are curr
Externí odkaz:
https://doaj.org/article/478832a5997e44388211a35b3a889871
Validating Automated Segmentation Tools in the Assessment of Caudate Atrophy in Huntington’s Disease
Autor:
Nina M. Mansoor, Tishok Vanniyasingam, Ian Malone, Nicola Z. Hobbs, Elin Rees, Alexandra Durr, Raymund A. C. Roos, Bernhard Landwehrmeyer, Sarah J. Tabrizi, Eileanoir B. Johnson, Rachael I. Scahill
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Background: Neuroimaging shows considerable promise in generating sensitive and objective outcome measures for therapeutic trials across a range of neurodegenerative conditions. For volumetric measures the current gold standard is manual delineation,
Externí odkaz:
https://doaj.org/article/026f447a265141ffb249f5f1aaf36811
Autor:
Eileanoir B. Johnson, Christopher S. Parker, Rachael I. Scahill, Sarah Gregory, Marina Papoutsi, Paul Zeun, Katherine Osborne-Crowley, Jessica Lowe, Akshay Nair, Carlos Estevez-Fraga, Kate Fayer, Geraint Rees, Hui Zhang, Sarah J. Tabrizi
Publikováno v:
EBioMedicine, Vol 65, Iss , Pp 103266- (2021)
Background: Pathological processes in Huntington's disease (HD) begin many years prior to symptom onset. Recently we demonstrated that in a premanifest cohort approximately 24 years from predicted disease onset, despite intact function, there was evi
Externí odkaz:
https://doaj.org/article/a5b119aef0874e58add8c97f8d4a0310
Autor:
Marina, Papoutsi, Michael, Flower, Davina J, Hensman Moss, Peter, Holmans, Carlos, Estevez-Fraga, Eileanoir B, Johnson, Rachael I, Scahill, Geraint, Rees, Douglas, Langbehn, Sarah J, Tabrizi, Bernhard, Landwehrmeyer
Publikováno v:
Brain Communications. 4
An important step towards the development of treatments for cognitive impairment in ageing and neurodegenerative diseases is to identify genetic and environmental modifiers of cognitive function and understand the mechanism by which they exert an eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b231440f44a9e5a993d6f99abda2189e
https://doi.org/10.1093/braincomms/fcac279
https://doi.org/10.1093/braincomms/fcac279
Autor:
Robb B. Rutledge, Sarah J. Tabrizi, Marina Papoutsi, Jessica Lowe, Paul Zeun, Sarah Gregory, Geraint Rees, Akshay Nair, Stefano Palminteri, Eileanoir B. Johnson, Katherine Osborne-Crowley, Rachael I. Scahill
Publikováno v:
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Background In this study, we asked whether differences in striatal activity during a reinforcement learning (RL) task with gain and loss domains could be one of the earliest functional imaging features associated with carrying the Huntington's diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca9d1a6f51ee087cf822f192a612507
https://doi.org/10.1016/j.bpsc.2020.12.015
https://doi.org/10.1016/j.bpsc.2020.12.015
Autor:
Eileanoir B. Johnson, Sarah Gregory, Hans J. Johnson, Alexandra Durr, Blair R. Leavitt, Raymund A. Roos, Geraint Rees, Sarah J. Tabrizi, Rachael I. Scahill
Publikováno v:
Frontiers in Neurology, Vol 8 (2017)
The selection of an appropriate segmentation tool is a challenge facing any researcher aiming to measure gray matter (GM) volume. Many tools have been compared, yet there is currently no method that can be recommended above all others; in particular,
Externí odkaz:
https://doaj.org/article/8dae0efc8f2d41bba4ec7177b690208f
Autor:
Fiona C Kinsella, Lauren M Byrne, Filipe B Rodrigues, Eileanoir B Johnson, Enrico De Vita, Daniel C Alexander, Giuseppe Palermo, Rachael I Scahill, Amanda Heslegrave, Henrik Zetterberg, Edward J Wild
Publikováno v:
D: Wet biomarkers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41303829328c9b2774fcb2d39b2b92bd
https://doi.org/10.1136/jnnp-2022-ehdn.64
https://doi.org/10.1136/jnnp-2022-ehdn.64
Autor:
Alexander J Lowe, Filipe B Rodrigues, Marzena Arridge, Enrico De Vita, Eileanoir B Johnson, Rachael I Scahill, Lauren M Byrne, Rosanna Tortelli, Amanda Heslegrave, Henrik Zetterberg, Edward J Wild
Publikováno v:
E: Imaging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22f7ff490fe52bf022f69c142bb2dbc1
https://doi.org/10.1136/jnnp-2022-ehdn.82
https://doi.org/10.1136/jnnp-2022-ehdn.82