Zobrazeno 1 - 10
of 388
pro vyhledávání: '"Eiko Ohtsuka"'
Autor:
Yoshinori Satow, Hideshi Yokoyama, Yasuo Komatsu, Ryuta Mizutani, Osamu Nikaido, Eiko Ohtsuka, Kousuke Sato
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 68:232-238
Pyrimidine (6–4) pyrimidone DNA photoproducts produced by ultraviolet light are highly mutagenic and carcinogenic. The crystal structure of the dTT(6–4)TT photoproduct in complex with the Fab fragment of the antibody 64M-2 that is specific for (6
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2144-2147
Solid-support conjugation at the 5'-terminal primary amine of oligonucleotides is a convenient and powerful method for introducing various functional groups. However, conventional aliphatic amines do not necessarily provide conjugates with sufficient
Autor:
Eiko Ohtsuka, Yutaka Tamura, Takami Sato, Michael J. Mastrangelo, David Berd, Mizue Terai, Vitali Alexeev
Publikováno v:
Cancer Immunology, Immunotherapy. 58:1307-1317
Interleukin 10 (IL-10) is produced by various types of human cancer, including malignant melanoma, and plays an important role in negative regulation of cell-mediated immune responses against tumors. We have developed chimeric molecules (immunoadhesi
Autor:
Naoki Fukuda, Chiemi Kimura, Hongyan Diao, Yutaka Matsui, Shigeyuki Kon, Daisuke Kurotaki, Yosuke Nakayama, Toshimitsu Uede, Eiko Ohtsuka, Yukio Fujiwara, Koyu Ito, Yasuo Komatsu, Masashi Kanayama, Yoshinari Saito
Publikováno v:
Human Gene Therapy. 18:1205-1214
Osteopontin (OPN) has been implicated in various helper T cell type 1 immunity-mediated diseases including rheumatoid arthritis (RA), multiple sclerosis (MS), Crohn's disease, and fulminant hepatitis. Increased expression of OPN has been detected in
Autor:
Maiko Sugino, Yumi Fujinawa, Naoshi Kojima, Muto Isamu, Matsubara Kenichi, Ken Nonaka, Yasuo Komatsu, Akiko Mikami, Eiko Ohtsuka
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5118-5121
We developed novel amino-modifying reagents, of which an amino group was connected with an aromatic residue by aliphatic linker. It was proved that the insertion of the aromatic residue could increase the reactivity of the amino group on oligonucleot
Autor:
Ichio Shimada, Eiko Ohtsuka, Hiroyuki Kobayashi, Koichi Kato, Tsukasa Matsunaga, Yasuo Komatsu, Osamu Nikaido, Kousuke Satou, Mikiko Kurihara, Takuya Torizawa, Makiyo Uchida, Hiroshi Morioka
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 25:667-679
A monoclonal antibody (DEM-1) specific for the Dewar photoproduct is used for detection and quantification of photolesions in DNA. To help understand the molecular recognition of damaged DNA by the antibody protein, we have cloned and sequenced the v
Autor:
Wakana Furushima, Eiko Ohtsuka, Satoko Kumada, Masaharu Hayashi, Akira Uchiyama, Yasuo Hachiya, Kiyoko Kurata, Yasushi Ito, Hidee Arai
Publikováno v:
Brain and Development. 27:574-578
In Japan, quite a few patients with spinal muscular atrophy type 1 (SMA type 1) survive with mechanical ventilation. Since a patient with SMA type 1 and continuous artificial ventilation exhibited excessive perspiration and tachycardia, we examined t
Autor:
Eiko Ohtsuka
Publikováno v:
Proceedings of the Japan Academy, Series B. 81:393-402
Non-Watson-Crick-type hydrogen bonds involving minor nucleosides such as inosine in anticodon loops of transfer RNA are found in nucleic acids. Inosine contains hypoxanthine as a nucleobase and can form base pairs with various bases in the genetic de
Autor:
Shigeru Sakurai, Toshio Hakoshima, Hiroto Yamaguchi, Kengo Okada, Makiyo Uchida, Hiroshi Morioka, Kotaro Fukuda, Ken Kitano, Eiko Ohtsuka, Keisuke Hamada
Publikováno v:
The EMBO Journal. 24:683-693
Flap endonuclease-1 (FEN1) is a key enzyme for maintaining genomic stability and replication. Proliferating cell nuclear antigen (PCNA) binds FEN1 and stimulates its endonuclease activity. The structural basis of the FEN1-PCNA interaction was reveale
Autor:
Yutaka Tamura, Satoshi Shuto, Tetsuya Kodama, Yoshihito Ueno, Yasuo Komatsu, Akira Matsuda, Eiko Ohtsuka, Shuichi Hoshika, Yuji Yamamoto, Satoshi Ichikawa
Publikováno v:
Biochemistry. 43:8690-8699
Components that form stable hairpin loops are highly useful for the development of functional DNA and RNA molecules. We have designed and synthesized a sugar-modified thymidine analogue, 3'-deoxy-4'-C-(2-hydroxyethyl)thymidine (X), as a nucleosidic l