Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Eiko Ohta"'
Autor:
Shinji Asada, Eiko Ohta, Yoriko Akimoto, Nona Abolhassani, Daisuke Tsuchimoto, Yusaku Nakabeppu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract 2-Oxoadenosine (2-oxo-Ado), an oxidized form of adenosine, is cytotoxic and induces growth arrest and cell death, which has potential as an anti-cancer drug. However, it is not well understood how 2-oxo-Ado exerts its cytotoxicity. We examin
Externí odkaz:
https://doaj.org/article/8f2b2ee957cb4c88b21e8bfbbc8767d9
Autor:
Yusaku Nakabeppu, Daisuke Tsuchimoto, Eiko Ohta, Nona Abolhassani, Yoriko Akimoto, Shinji Asada
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports
2-Oxoadenosine (2-oxo-Ado), an oxidized form of adenosine, is cytotoxic and induces growth arrest and cell death, which has potential as an anti-cancer drug. However, it is not well understood how 2-oxo-Ado exerts its cytotoxicity. We examined the ef
Publikováno v:
Free radical biologymedicine. 107
8-Oxo-7,8-dihydroguanine (GO) can originate as 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP), an oxidized form of dGTP in the nucleotide pool, or by direct oxidation of guanine base in DNA. Accumulation of GO in cellular genomes ca
Autor:
Eiko Ohta, Kijiro Hashimoto, Makoto Hirano, Toshihide Kuroki, H. Yamada, Tatsuo Nakahara, T. Kajihata, M. Yamanaka, Tetsuyuki Tsutsumi, Hideyuki Uchimura
Publikováno v:
Parkinsonism & Related Disorders. 9:213-219
We previously reported that haloperidol, a dopamine-D 2 receptor antagonist, induced striatal expression of parkin gene, which mutations cause autosomal recessive juvenile parkinsonism. Because of an involvement of the parkin gene defect in selective
Autor:
Makoto Hirano, Hideyuki Uchimura, Leo Gotoh, Tatsuo Nakahara, Hisao Hondo, Toshihide Kuroki, Noriko Kawanami, Keisuke Motomura, Eiko Ohta, Izumi Kanchiku
Publikováno v:
Molecular Brain Research. 100:1-12
Because of the possible interaction between adenosine receptors and dopaminergic functions, the compound acting on the specific adenosine receptor subtype may be a candidate for novel antipsychotic drugs. To elucidate the antipsychotic potential of t
Autor:
Makoto Hirano, Tatsuo Nakahara, Leo Gotoh, Eiko Ohta, Noriko Kawanami, Keisuke Motomura, Hideyuki Uchimura
Publikováno v:
Neuroscience Letters. 306:93-96
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. We examined the effects of acute and chronic treatment with haloperidol on parkin mRNA expression in the rat brain by reverse transcription-polymerase chain reaction. Acute
Autor:
Daisuke Tsuchimoto, Nona Abolhassani, Kunihiko Sakumi, Yusaku Nakabeppu, Eiko Ohta, Mari Nonaka, Teruaki Iyama
Publikováno v:
Mutation research. 703(1)
To identify novel nucleotide pool sanitizing enzymes, we have established a comprehensive screening system for damaged nucleotide-binding proteins based on proteomics technology. In the screening system, affinity chromatography with resins carrying v