Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Eiko Hayase"'
Autor:
Eiko Hayase, Robert R. Jenq
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block immune inhibitory pathways. Administration of ICIs augments T cell-mediated immune responses against tumor, resulting in improved overall survival in cancer patients. I
Externí odkaz:
https://doaj.org/article/ea8edb5674854cc283a7161dad05859c
Autor:
Satomi Matsuoka, Daigo Hashimoto, Masanori Kadowaki, Hiroyuki Ohigashi, Eiko Hayase, Emi Yokoyama, Yuta Hasegawa, Takahiro Tateno, Xuanzhong Chen, Kazutoshi Aoyama, Hideyo Oka, Masahiro Onozawa, Kiyoshi Takeda, Koichi Akashi, Takanori Teshima
Publikováno v:
Haematologica, Vol 105, Iss 1 (2020)
Myeloid differentiation factor 88 (MyD88) signaling has a crucial role in activation of both innate and adoptive immunity. MyD88 transduces signals via Toll-like receptor and interleukin-1 receptor superfamily to the NFκB pathway and inflammasome by
Externí odkaz:
https://doaj.org/article/ccd944044c6c4e4db443ee24cd88437a
Autor:
Reiki Ogasawara, Daigo Hashimoto, Shunsuke Kimura, Eiko Hayase, Takahide Ara, Shuichiro Takahashi, Hiroyuki Ohigashi, Kosuke Yoshioka, Takahiro Tateno, Emi Yokoyama, Ko Ebata, Takeshi Kondo, Junichi Sugita, Masahiro Onozawa, Toshihiko Iwanaga, Takanori Teshima
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract The R-Spondin (R-Spo) family regulates WNT signaling and stimulates the proliferation and differentiation of intestinal stem cells (ISCs). R-Spo plays a critical role in maintaining intestinal homeostasis, but endogenous producers of R-Spo i
Externí odkaz:
https://doaj.org/article/21d1a0abb22b4c0eb8207b01cd6ddb8b
Autor:
Christoph K. Stein-Thoeringer, Neeraj Y. Saini, Eli Zamir, Viktoria Blumenberg, Maria-Luisa Schubert, Uria Mor, Matthias A. Fante, Sabine Schmidt, Eiko Hayase, Tomo Hayase, Roman Rohrbach, Chia-Chi Chang, Lauren McDaniel, Ivonne Flores, Rogier Gaiser, Matthias Edinger, Daniel Wolff, Martin Heidenreich, Paolo Strati, Ranjit Nair, Dai Chihara, Luis E. Fayad, Sairah Ahmed, Swaminathan P. Iyer, Raphael E. Steiner, Preetesh Jain, Loretta J. Nastoupil, Jason Westin, Reetakshi Arora, Michael L. Wang, Joel Turner, Meghan Menges, Melanie Hidalgo-Vargas, Kayla Reid, Peter Dreger, Anita Schmitt, Carsten Müller-Tidow, Frederick L. Locke, Marco L. Davila, Richard E. Champlin, Christopher R. Flowers, Elizabeth J. Shpall, Hendrik Poeck, Sattva S. Neelapu, Michael Schmitt, Marion Subklewe, Michael D. Jain, Robert R. Jenq, Eran Elinav
Publikováno v:
Nat Med
Increasing evidence suggests that the gut microbiome may modulate the efficacy of cancer immunotherapy. In a B cell-lymphoma patient cohort from five centers in Germany and the United States (Germany, N=66; US, N=106, Total, N=172), we demonstrate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b678db32d5c1d49ee86ffd70077e4ff
https://europepmc.org/articles/PMC10121864/
https://europepmc.org/articles/PMC10121864/
Autor:
Robert Jenq, Eiko Hayase, Tomo Hayase, Akash Mukherjee, Stuart Stinson, Mohamed Jamal, Miriam Ortega, Christopher Sanchez, Saira Ahmed, Jennifer Karmouch, Chia-Chi Chang, Ivonne Flores, Lauren McDaniel, Alexandria Brown, Rawan El-Himri, Valerie Chapa, Lin Tan, Bao Tran, Dung Pham, Taylor Halsey, Yimei Jin, Wen-Bin Tsai, Rishika Prasad, Israel Glover, Nadim Ajami, Jennifer Wargo, Samuel Shelburne, Pablo Okhuysen, Chen Liu, Stephanie Fowler, Margaret Conner, Christine Peterson, Gabriela Rondon, Jeffrey J Molldrem, Richard Champlin, Elizabeth Shpall, Philip Lorenzi, Rohtesh Mehta, Eric Martens, Amin Alousi
Acute gastrointestinal intestinal GVHD (aGI-GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation, and the intestinal microbiota is known to impact on its severity. However, an association between treatment response of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df4c8357b3a9282378e4c16512e977a0
https://doi.org/10.21203/rs.3.rs-2460097/v1
https://doi.org/10.21203/rs.3.rs-2460097/v1
Autor:
Xuanzhong Chen, Daigo Hashimoto, Ko Ebata, Shuichiro Takahashi, Yu Shimizu, Ryuga Shinozaki, Yuta Hasegawa, Ryo Kikuchi, Hajime Senjo, Kazuki Yoneda, Zixuan Zhang, Shinpei Harada, Eiko Hayase, Takahide Ara, Hiroyuki Ohigashi, Yoichiro Iwakura, Kiminori Nakamura, Tokiyoshi Ayabe, Takanori Teshima
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(48)
Granulopoiesis in the bone marrow adjusts cellular output as demand for neutrophils changes. Reactive granulopoiesis is induced by profound neutropenia, but its mechanism remains to be clarified. We herein explored its mechanisms using mouse models o
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment
Autor:
Zaker I. Schwabkey, Diana H. Wiesnoski, Chia-Chi Chang, Wen-Bin Tsai, Dung Pham, Saira S. Ahmed, Tomo Hayase, Miriam R. Ortega Turrubiates, Rawan K. El-Himri, Christopher A. Sanchez, Eiko Hayase, Annette C. Frenk Oquendo, Takahiko Miyama, Taylor M. Halsey, Brooke E. Heckel, Alexandria N. Brown, Yimei Jin, Mathilde Raybaud, Rishika Prasad, Ivonne Flores, Lauren McDaniel, Valerie Chapa, Philip L. Lorenzi, Marc O. Warmoes, Lin Tan, Alton G. Swennes, Stephanie Fowler, Margaret Conner, Kevin McHugh, Tyler Graf, Vanessa B. Jensen, Christine B. Peterson, Kim-Anh Do, Liangliang Zhang, Yushu Shi, Yinghong Wang, Jessica R. Galloway-Pena, Pablo C. Okhuysen, Carrie R. Daniel-MacDougall, Yusuke Shono, Marina Burgos da Silva, Jonathan U. Peled, Marcel R.M. van den Brink, Nadim Ajami, Jennifer A. Wargo, Pavan Reddy, Raphael H. Valdivia, Lauren Davey, Gabriela Rondon, Samer A. Srour, Rohtesh S. Mehta, Amin M. Alousi, Elizabeth J. Shpall, Richard E. Champlin, Samuel A. Shelburne, Jeffrey J. Molldrem, Mohamed A. Jamal, Jennifer L. Karmouch, Robert R. Jenq
Publikováno v:
Sci Transl Med
Not all patients with cancer and severe neutropenia develop fever, and the fecal microbiome may play a role. In a single-center study of patients undergoing hematopoietic cell transplant ( n = 119), the fecal microbiome was characterized at onset of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f7e0812f8761b8d4fbf1944a540f64
https://europepmc.org/articles/PMC10028729/
https://europepmc.org/articles/PMC10028729/
Autor:
Feiyan Mo, Norihiro Watanabe, Kayleigh I. Omdahl, Phillip M. Burkhardt, Xiaoyun Ding, Eiko Hayase, Angela Panoskaltsis-Mortari, Robert R. Jenq, Helen E. Heslop, Leslie S. Kean, Malcolm K. Brenner, Victor Tkachev, Maksim Mamonkin
Publikováno v:
Blood.
Acute graft-versus-host disease (aGVHD) limits the therapeutic benefit of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and requires immunosuppressive prophylaxis that compromises antitumor and antipathogen immunity. OX40 is a costim
Publikováno v:
Expert Opin Biol Ther
INTRODUCTION: Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is commonly performed to treat a variety of benign and malignant hematological diseases. Acute graft-versus-host disease (GVHD) is a major life-threatening complication that
Autor:
Eiko Hayase, Tomo Hayase, Mohamad A. Jamal, Takahiko Miyama, Chia-Chi Chang, Miriam R. Ortega, Saira S. Ahmed, Jennifer L. Karmouch, Christopher A. Sanchez, Alexandria N. Brown, Rawan K. El.-Himri, Ivonne I. Flores, Lauren K. McDaniel, Dung Pham, Taylor Halsey, Annette C. Frank, Valerie A. Chapa, Brooke E. Heckel, Wen-Bin Tsai, Rishika Prasad, Lin Tan, Lucas Veillon, Nadim Adjami, Jennifer Wargo, Jessica Galloway-Pena, Samuel Shelburne, Roy F. Chemaly, Lauren Davey, Robert WP Glowacki, Chen Liu, Gabriela Rondon, Amin M. Alousi, Jeffrey Molldrem, Richard Champlin, Elizabeth Shpall, Richard H. Valdivia, Eric C. Martens, Philip L. Lorenzi, Robert R. Jenq
Publikováno v:
Leading Edge of Cancer Research Symposium: Poster Session.