Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Eiki Tanabe"'
Autor:
Osamu Tani, Tatsuya Niimi, Yukihiro Tateishi, Kazuhiko Yamasaki, Koji Furukawa, Hitoshi Sakashita, Ichiji Namatame, Eiki Tanabe
Publikováno v:
Journal of Medicinal Chemistry. 59:2261-2266
Although NMR in fragment-based drug discovery is utilized almost exclusively to evaluate physical binding between molecules, it should be also a powerful tool for biochemical assay, evaluating inhibitory effect of compounds on enzymatic activity. Tim
Autor:
Hitoshi Sakashita, Yukihiro Tateishi, Tatsuya Niimi, Yasushi Amano, Ichiji Namatame, Kazuya Honboh, Eiki Tanabe
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 71:1879-1889
Trypanosoma cruzicauses Chagas disease, a severe disease affecting 8–10 million people in Latin America. While nifurtimox and benznidazole are used to treat this disease, their efficacy is limited and adverse effects are observed. New therapeutic t
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:2427-2434
Soluble epoxide hydrolase (sEH) is a component of the arachidonic acid cascade and is a candidate target for therapies for hypertension or inflammation. Although many sEH inhibitors are available, their scaffolds are not structurally diverse, and kno
Publikováno v:
Bioorganicmedicinal chemistry. 23(10)
Soluble epoxide hydrolase (sEH) is a potential target for the treatment of inflammation and hypertension. X-ray crystallographic fragment screening was used to identify fragment hits and their binding modes. Eight fragment hits were identified via so
Autor:
Kouhei Tsumoto, Izumi Kumagai, Yoshiaki Yasutake, Min Yao, Yoshikazu Tanaka, Isao Tanaka, Eiki Tanabe, Naoki Sakai
Publikováno v:
Proteins. 61(4)
Introduction. ST2072 is a hypothetical function unknown protein from the thermophilic archaeon Sulfolobus tokodaii and is categorized into the protein family named “protein of unknown function UPF0047.” The presence of UPF0047 among diverse bacte
Autor:
Kazuhiko Yamasaki, Osamu Tani, Yukihiro Tateishi, Eiki Tanabe, Ichiji Namatame, Tatsuya Niimi, Koji Furukawa, Hitoshi Sakashita
Publikováno v:
Journal of Medicinal Chemistry; Mar2016, Vol. 59 Issue 5, p2261-2266, 6p