Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Eiki Shitara"'
Autor:
Takehiro Fukami, Yui Mazaki, Kenichi Washizuka, Hideaki Niwa, Takeshi Tsumura, Hiroo Koyama, Yuko Kano, Yasuko Koda, Fumiyuki Shirai, Kouichi Kitamura, Yoko Yashiroda, Anna Mizutani, Hitomi Yuki, Eiki Shitara, Hiroyuki Seimiya, Teruki Honma, Shin Sato, Tsubasa Chikada, Minoru Yoshida, Masayuki Okue, Takashi Watanabe, Takashi Umehara, Yukiko Muramatsu, Akiko Nagamori, Myung-Kyu Jang, Haruka Yoshida, Mikako Shirouzu
Publikováno v:
Journal of medicinal chemistry. 63(8)
Tankyrases (TNKS/TNKS2) belong to the poly(ADP-ribose) polymerase family. Inhibition of their enzymatic activities attenuates the Wnt/β-catenin signaling, which plays an important role in cancer pathogenesis. We previously reported the discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30c01958ef416b8aff1cab18d74f999
https://pubmed.ncbi.nlm.nih.gov/32202790
https://pubmed.ncbi.nlm.nih.gov/32202790
Autor:
Eijiro Umemura, Yoshinari Wakiyama, Ko Kumura, Kazutaka Ueda, Hideki Fushimi, Takashi Watanabe, Keiichi Ajito, Eiki Shitara, Takuji Yoshida
Publikováno v:
The Journal of Antibiotics. 69:440-445
The synthesis and antibacterial activity of (7S)-7-sulfur-azetidin-3-yl lincomycin derivatives are described. Modification was achieved by a simple reaction of (7R)-7-O-methanesulfonyllincomycin and the corresponding substituted azetidine-2-thiol. Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d30e339fef0c158e12c0979528c074
https://doi.org/10.1038/ja.2015.134
https://doi.org/10.1038/ja.2015.134
Autor:
Tomoaki Miura, Kenichi Kanemoto, Hideki Fushimi, Keiichi Ajito, Takuji Yoshida, Eiki Shitara, Satomi Natsume
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:2735-2747
The design and synthesis of 16-membered azalides modified at the C-15 and 4'' positions are described. The compounds we report here are characterized by an arylpropenyl group attached to the C-15 position of macrolactone and a carbamoyl group at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40701d9e952ff05593e530a223e48241
https://doi.org/10.1016/j.bmc.2010.02.017
https://doi.org/10.1016/j.bmc.2010.02.017
Autor:
Takahisa Maruyama, Eiji Matsuhisa, Hiromi Meiji Seika Kaisha Ltd. Takata, Eiki Shitara, Katsuyoshi Iwamatsu, Yuko Kano, Toshihiko Takata, Yasuo Yamamoto, Mizuyo Kurazono, Kunio Atsumi
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:6379-6387
A new series of 1β-methyl carbapenems possessing a 6,7-disubstituted imidazo[5,1- b ]thiazol-2-yl group directly attached to the C-2 position of the carbapenem nucleus was prepared, and the activities of these compounds against methicillin-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cce067b89fc783d0406088dd28b68de
https://doi.org/10.1016/j.bmc.2007.06.057
https://doi.org/10.1016/j.bmc.2007.06.057
Synthesis and SAR study of novel 7-(pyridinium-3-yl)-carbonyl imidazo[5,1-b]thiazol-2-yl carbapenems
Autor:
Katsuyoshi Iwamatsu, Yasuo Yamamoto, Takahisa Maruyama, Kunio Atsumi, Eiki Shitara, Mizuyo Kurazono, Yuko Kano
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:392-402
A new series of 1β-methyl carbapenems, possessing a 7-substituted imidazo[5,1- b ]thiazol-2-yl group directly attached to the C-2 position of the carbapenem nucleus, was synthesized and evaluated for antibacterial activity. These compounds showed po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41986aaa132f2be4097a5ea2a744dc15
https://doi.org/10.1016/j.bmc.2006.09.049
https://doi.org/10.1016/j.bmc.2006.09.049
Autor:
Eiki Shitara, Minoru Yonezawa, Yoko Hirai, Takahisa Maruyama, Mizuyo Kurazono, Takashi Ida, Keiko Yamada
Publikováno v:
Antimicrobial Agents and Chemotherapy. 48:2831-2837
ME1036, formerly CP5609, is a novel parenteral carbapenem with a 7-acylated imidazo[5,1- b ]thiazole-2-yl group directly attached to the carbapenem moiety of the C-2 position. The present study evaluated the in vitro activities of ME1036 against clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b62c29843e2495c62af4e6bbb22aaad
https://doi.org/10.1128/aac.48.8.2831-2837.2004
https://doi.org/10.1128/aac.48.8.2831-2837.2004
Publikováno v:
Organic Letters. 2:3837-3840
[reaction: see text] 6-Acetamido-5-amino- and -5-guanidino-3, 4-dehydro-N-(2-ethylbutyryl)-3-piperidinecarboxylic acids (8 and 9) have been synthesized starting from natural siastatin B, a bacterial neuraminidase inhibitor isolated from Streptomyces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c60a40814e5205d02ba549dc7e807fd
https://doi.org/10.1021/ol000261d
https://doi.org/10.1021/ol000261d
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:343-352
An efficient route from D-ribono-gamma-lactone to gem-diamine 1-N-iminosugars of L-fucose-type, a new family of glycosidase inhibitor, has been developed in a formation of a gem-diamine 1-N-iminopyranose ring by the Mitsunobu reaction of an aminal as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0c8a5ec10c97c18a389ef2857bebb6
https://doi.org/10.1016/s0968-0896(99)00289-8
https://doi.org/10.1016/s0968-0896(99)00289-8
Publikováno v:
Bioorganic & Medicinal Chemistry. 7:1241-1246
gem-Diamine 1-N iminosugars of d -glucose-type, a new type of glycosidase inhibitors, have been synthesized from siastatin B, isolated from Streptomyces culture. 2-Trifluoroacetamido-1-N-iminosugar, (2S,3R,4R,5R)-2-trifluoroacetamido-5-hydroxymethylp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c95f10bfe8dbc3291ba3de60930458
https://doi.org/10.1016/s0968-0896(99)00048-6
https://doi.org/10.1016/s0968-0896(99)00048-6
Publikováno v:
Tetrahedron Letters. 40:2351-2354
Gem-diamine 1-N-iminosugars of l-fucose-type, a new type of glycosidase inhibitor, have been synthesized from d-ribono-γ-lactone, involving the formation of a gem-diamine 1-N-iminopyranose ring by the Mitsunobu reaction of an aminal as a key step. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51ae6e7081b3706973278682c53715db
https://doi.org/10.1016/s0040-4039(99)00184-7
https://doi.org/10.1016/s0040-4039(99)00184-7