Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Eiki Koyama"'
Autor:
Christina Mundy, Lutian Yao, Kelly A. Shaughnessy, Cheri Saunders, Eileen M. Shore, Eiki Koyama, Maurizio Pacifici
Publikováno v:
JBMR Plus, Vol 7, Iss 12, Pp n/a-n/a (2023)
ABSTRACT Heterotopic ossification (HO) consists of extraskeletal bone formation. One form of HO is acquired and instigated by traumas or surgery, and another form is genetic and characterizes fibrodysplasia ossificans progressiva (FOP). Recently, we
Externí odkaz:
https://doaj.org/article/f17c27e7c498471f95ec93e2a5fac5b4
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 461-475 (2021)
Inactivation mutations in the Indian hedgehog (Ihh) gene in humans cause numerous skeletal chondrodysplasias, including acrocapitofemoral dysplasia, brachydactyly type A1, and human short stature. The lack of an appropriate human-relevant model to ac
Externí odkaz:
https://doaj.org/article/91e93e5844814980b3ca6a198b49e200
Autor:
Minwook Kim, Eiki Koyama, Cheri M. Saunders, William Querido, Nancy Pleshko, Maurizio Pacifici
Publikováno v:
Biology Open, Vol 11, Iss 6 (2022)
The synovial cavity and its fluid are essential for joint function and lubrication, but their developmental biology remains largely obscure. Here, we analyzed E12.5 to E18.5 mouse embryo hindlimbs and discovered that cavitation initiates around E15.0
Externí odkaz:
https://doaj.org/article/5c2382a6f84441d485bfe33f37c932cd
Autor:
Yulong Wei, Hao Sun, Tao Gui, Lutian Yao, Leilei Zhong, Wei Yu, Su-Jin Heo, Lin Han, Nathaniel A Dyment, Xiaowei Sherry Liu, Yejia Zhang, Eiki Koyama, Fanxin Long, Miltiadis H Zgonis, Robert L Mauck, Jaimo Ahn, Ling Qin
Publikováno v:
eLife, Vol 10 (2021)
Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-modifying therapies. Using a Gli1 reporter line, we found that Gli1+ cells contribute to the development of meniscus horns from 2 weeks of age. In adult mi
Externí odkaz:
https://doaj.org/article/f623562d2d094d8fa2bb24d452a21fa8
Autor:
Sayantani Sinha, Christina Mundy, Till Bechtold, Federica Sgariglia, Mazen M Ibrahim, Paul C Billings, Kristen Carroll, Eiki Koyama, Kevin B Jones, Maurizio Pacifici
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006742 (2017)
Hereditary Multiple Exostoses (HME) is a rare pediatric disorder caused by loss-of-function mutations in the genes encoding the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2. HME is characterized by formation of cartilaginous outgrowths-call
Externí odkaz:
https://doaj.org/article/159fca4cf78b4771b52c75012998f62f
Autor:
Danielle Rux, Kimberly Helbig, Biao Han, Courtney Cortese, Eiki Koyama, Lin Han, Maurizio Pacifici
Publikováno v:
J Bone Miner Res
Articular cartilage (AC) is essential for body movement but is highly susceptible to degenerative diseases and has poor self-repair capacity. To improve current subpar regenerative treatments, developmental mechanisms of AC should be clarified and, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215c89b6fed1342c899f5410c6cab986
https://europepmc.org/articles/PMC9177786/
https://europepmc.org/articles/PMC9177786/
Autor:
Christina Mundy, Juliet Chung, Eiki Koyama, Stuart Bunting, Rajeev Mahimkar, Maurizio Pacifici
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 40(10)
Hereditary multiple exostoses (HME) is a rare, pediatric disorder characterized by osteochondromas that form along growth plates and provoke significant musculoskeletal problems. HME is caused by mutations in heparan sulfate (HS)-synthesizing enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc60bb27ef4f7efe347689fded17036
https://pubmed.ncbi.nlm.nih.gov/34996123
https://pubmed.ncbi.nlm.nih.gov/34996123
Publikováno v:
FASEB J
The incredible mechanical strength and durability of mature fibrous tissues and their extremely limited turnover and regenerative capacity underscores the importance of proper matrix assembly during early postnatal growth. In tissues with composite e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d175dca3aa8abd7a57c7889a4f7d8d
https://doi.org/10.1096/fj.202100499r
https://doi.org/10.1096/fj.202100499r
Autor:
Chao Wang, Daphney R. Chery, David B. Frank, David E. Birk, Robert L. Mauck, Prashant Chandrasekaran, Nathaniel A. Dyment, Eiki Koyama, Bryan Kwok, Biao Han, X. Lucas Lu, Sheila M. Adams, Lin Han
Publikováno v:
Matrix Biol
This study queried the role of type V collagen in the post-natal growth of temporomandibular joint (TMJ) condylar cartilage, a hybrid tissue with a fibrocartilage layer covering a secondary hyaline cartilage layer. Integrating outcomes from histology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b90f5b7562db364a5b87eeb6d5527a4
https://europepmc.org/articles/PMC8549065/
https://europepmc.org/articles/PMC8549065/
Autor:
Courtney Cortese, Danielle Rux, Biao Han, Maurizio Pacifici, Lin Han, Eiki Koyama, Kimberly Helbig
Articular cartilage (AC) is essential for body movement, but is highly susceptible to degenerative diseases and has poor self-repair capacity. To improve current subpar regenerative treatment, developmental mechanisms of AC should be clarified and, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63a02008b2613fc813d5da27672b2723
https://doi.org/10.1101/2021.07.04.451018
https://doi.org/10.1101/2021.07.04.451018