Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Eiki, Takimoto"'
Autor:
Satoshi Bujo, Haruhiro Toko, Kaoru Ito, Satoshi Koyama, Masato Ishizuka, Masahiko Umei, Haruka Yanagisawa-Murakami, Jiaxi Guo, Bowen Zhai, Chunxia Zhao, Risa Kishikawa, Norifumi Takeda, Kensuke Tsushima, Yuichi Ikeda, Eiki Takimoto, Hiroyuki Morita, Mutsuo Harada, Issei Komuro
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Cardiovascular disease (CVD) is a global health burden in the world. Although low-carbohydrate diets (LCDs) have beneficial effects on CVD risk, their preventive effects remain elusive. We investigated whether LCDs ameliorate heart failure (
Externí odkaz:
https://doaj.org/article/48ca2affdf77439ca88ffad8353c678a
Autor:
Takayuki Fujiwara, Norifumi Takeda, Hironori Hara, Satoshi Ishii, Genri Numata, Hiroyuki Tokiwa, Manami Katoh, Sonoko Maemura, Takaaki Suzuki, Hiroshi Takiguchi, Tomonobu Yanase, Yoshiaki Kubota, Seitaro Nomura, Masaru Hatano, Kazutaka Ueda, Mutsuo Harada, Haruhiro Toko, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Satoshi Nishimura, Issei Komuro
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Pulmonary hypertension (PH) is a life-threatening disease characterized by a progressive narrowing of pulmonary arterioles. Although VEGF is highly expressed in lung of patients with PH and in animal PH models, the involvement of angiogenesis remains
Externí odkaz:
https://doaj.org/article/ce45defeeabf440ab551c4e01201796d
Autor:
Yusuke Adachi, Kazutaka Ueda, Seitaro Nomura, Kaoru Ito, Manami Katoh, Mikako Katagiri, Shintaro Yamada, Masaki Hashimoto, Bowen Zhai, Genri Numata, Akira Otani, Munetoshi Hinata, Yuta Hiraike, Hironori Waki, Norifumi Takeda, Hiroyuki Morita, Tetsuo Ushiku, Toshimasa Yamauchi, Eiki Takimoto, Issei Komuro
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Perivascular adipose tissue (PVAT) has been reported to undergo inflammatory changes in response to vascular injury. Here, the authors show that vascular injury induces the beiging (brown adipose tissue-like phenotype change) of PVAT, which fine-tune
Externí odkaz:
https://doaj.org/article/cb7e802d38434896b4bb279da62c5f38
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Most blood vessels are surrounded by adipose tissues known as perivascular adipose tissue (PVAT). Emerging experimental data have implicated the potential involvement of PVAT in the pathogenesis of cardiovascular disease: PVAT might be a source of in
Externí odkaz:
https://doaj.org/article/8b30a8f35b7943d5b8b4d409503496d4
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Sexual dimorphism exists in the epidemiology of cardiovascular disease (CVD), which indicates the involvement of sexual hormones in the pathophysiology of CVD. In particular, ample evidence has demonstrated estrogen's protective effect on the cardiov
Externí odkaz:
https://doaj.org/article/22c278a37dce4141811ca12a652540d3
Autor:
Ryo Matsuura, Tetsushi Yamashita, Naoki Hayase, Yoshifumi Hamasaki, Eisei Noiri, Genri Numata, Eiki Takimoto, Masaomi Nangaku, Kent Doi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Although chronic heart failure is clinically associated with acute kidney injury (AKI), the precise mechanism that connects kidney and heart remains unknown. Here, we elucidate the effect of pre-existing heart failure with reduced ejection f
Externí odkaz:
https://doaj.org/article/c4c2ada1e8b048e78937f72e4290ce63
Autor:
Pang-Yen Liu, Kun-Zhe Tsai, Yen-Po Lin, Chin-Sheng Lin, Huan-Chang Zeng, Eiki Takimoto, Gen-Min Lin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The prevalence of mitral valve prolapse (MVP) among middle- and older-aged individuals is estimated to be 2–4% in Western countries. However, few studies have been conducted among Asian individuals and young adults. This study included a s
Externí odkaz:
https://doaj.org/article/487fcf4de89f454eacb3dfc3abbb0e67
Autor:
Yusuke Adachi, Arihiro Kiyosue, Jiro Ando, Takuya Kawahara, Satoshi Kodera, Shun Minatsuki, Hironobu Kikuchi, Toshiro Inaba, Hiroyuki Kiriyama, Kazutoshi Hirose, Hiroki Shinohara, Akihito Saito, Takayuki Fujiwara, Hironori Hara, Kazutaka Ueda, Kenichi Sakakura, Masaru Hatano, Mutsuo Harada, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Shin-ichi Momomura, Hideo Fujita, Issei Komuro
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Percutaneous coronary intervention (PCI) is sometimes considered as an alternative therapeutic strategy to surgical revascularization in patients with coronary artery disease (CAD) and reduced left ventricular ejection fraction (LVEF). Howev
Externí odkaz:
https://doaj.org/article/35f42b33a23b42768f39111d54f23fde
Autor:
Genri Numata, Eiki Takimoto
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Cyclic guanosine monophosphate (cGMP), produced by guanylate cyclase (GC), activates protein kinase G (PKG) and regulates cardiac remodeling. cGMP/PKG signal is activated by two intrinsic pathways: nitric oxide (NO)-soluble GC and natriuretic peptide
Externí odkaz:
https://doaj.org/article/34f94b4ab7534f8daa39fc0235fb700a
Autor:
Haruhiro Toko, Hiroyuki Morita, Masanori Katakura, Michio Hashimoto, Toshiyuki Ko, Satoshi Bujo, Yusuke Adachi, Kazutaka Ueda, Haruka Murakami, Masato Ishizuka, Jiaxi Guo, Chunxia Zhao, Takayuki Fujiwara, Hironori Hara, Norifumi Takeda, Eiki Takimoto, Osamu Shido, Mutsuo Harada, Issei Komuro
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Some clinical trials showed that omega-3 fatty acid (FA) reduced cardiovascular events, but it remains unknown whether omega-3 FA supplementation changes the composition of FAs and their metabolites in the heart and how the changes, if any,
Externí odkaz:
https://doaj.org/article/b3a55341d22e4566988785eb3ba384b2