Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Eiki, Takahashi"'
Autor:
Mai Horiuchi, Seiji Watanabe, Okiru Komine, Eiki Takahashi, Kumi Kaneko, Shigeyoshi Itohara, Mayuko Shimada, Tomoo Ogi, Koji Yamanaka
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract Nuclear clearance and cytoplasmic aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) are pathological hallmarks of amyotrophic lateral sclerosis (ALS) and its pathogenic mechanism is mediated by both loss-of-function and gain-of-toxic
Externí odkaz:
https://doaj.org/article/de7cca76fa07411da4519af7bfb11bdf
Autor:
Xu Zhang, Ying Zhou, Lei Chen, Qian Zhao, Yuting Li, Shuai Wang, Weidong Li, Minggang Liu, Zhaohui Lan, Xiujuan Yang, Longyong Xu, Yifang Kuang, Tatsuo Suzuki, Katsuhiko Tabuchi, Eiki Takahashi, Miou Zhou, Charlie Degui Chen, Tianle Xu
Publikováno v:
General Psychiatry, Vol 37, Iss 5 (2024)
Background Kabuki syndrome (KS) is a rare developmental disorder characterised by multiple congenital anomalies and intellectual disability. UTX (ubiquitously transcribed tetratricopeptide repeat, X chromosome), which encodes a histone demethylase, i
Externí odkaz:
https://doaj.org/article/a919775b7fd947ab9441d13a413119b5
Autor:
Xiangyu Yang, Zhitang Chen, Ziying Wang, Guang He, Zhiqiang Li, Yongyong Shi, Neng Gong, Binglei Zhao, Yifang Kuang, Eiki Takahashi, Weidong Li
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-4 (2022)
Abstract Epilepsy has been extensively studied as a common neurological disease. Efforts have been made on rodent and other animal models to reveal the pathogenic mechanisms of epilepsy and develop new drugs for treatment. However, the features of cu
Externí odkaz:
https://doaj.org/article/b9e40c75d51440d094505c689c59cf42
Autor:
Kazuki Kodama, Hiroaki Takahashi, Nobuyasu Oiji, Kenta Nakano, Tadashi Okamura, Kimie Niimi, Eiki Takahashi, Long Guo, Shiro Ikegawa, Tatsuya Furuichi
Publikováno v:
FEBS Open Bio, Vol 10, Iss 6, Pp 1096-1103 (2020)
Desbuquois dysplasia (DD) type 1 is a rare skeletal dysplasia characterized by a short stature, round face, progressive scoliosis, and joint laxity. The causative gene has been identified as calcium‐activated nucleotidase 1 (CANT1), which encodes a
Externí odkaz:
https://doaj.org/article/fc5c8ae823b246b7aa3e657464d34bda
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101152- (2021)
Diet is a key modifiable factor influencing the composition of gut microbiota. There are two types of commercially available diets for experimental animals: non-purified and semi-purified diets. Non-purified diets are composed of complex ingredients
Externí odkaz:
https://doaj.org/article/093a3234248f4544b3d4bee9b6e89589
Autor:
Zhitang Chen, Zheng Dou, Hui Xu, Zhenghua Wang, Suhua Zeng, Xiangyu Yang, Eiki Takahashi, Milos R. Popovic, Lihui Wang, Weidong Li
Publikováno v:
Brain Sciences, Vol 13, Iss 1, p 38 (2022)
It is generally believed that working memory (WM) is dysfunctional in depression. However, whether this impaired performance originates from impaired encoding, maintenance or both stages is still unclear. Here, we aimed to decompose the abnormal char
Externí odkaz:
https://doaj.org/article/ac35b3bb3de643509f17487f9c52a324
Autor:
Seiji Watanabe, Kotaro Oiwa, Yuri Murata, Okiru Komine, Akira Sobue, Fumito Endo, Eiki Takahashi, Koji Yamanaka
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-4 (2020)
Abstract Abnormal accumulation of TAR DNA-binding protein 43 (TDP-43), a DNA/RNA binding protein, is a pathological signature of amyotrophic lateral sclerosis (ALS). Missense mutations in the TARDBP gene are also found in inherited and sporadic ALS,
Externí odkaz:
https://doaj.org/article/80056028ba3c4d8fa0b6fa0a5b472e83
Publikováno v:
Heliyon, Vol 6, Iss 3, Pp e03524- (2020)
The most widely used animal models to develop sleep-disorder drugs are rodents, particularly rats and mice. However, unlike humans, these rodents are nocturnal. Thus, diurnal non-human primates represent a valuable and more translational animal model
Externí odkaz:
https://doaj.org/article/f3ef003b167f454595777c07557985bf
Autor:
Xuemei Chen, Shuai Wang, Ying Zhou, Yanfei Han, Shengtian Li, Qing Xu, Longyong Xu, Ziqi Zhu, Youming Deng, Lu Yu, Lulu Song, Adele Pin Chen, Juan Song, Eiki Takahashi, Guang He, Lin He, Weidong Li, Charlie Degui Chen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Mutations in PHF8 gene are genetically associated with X-linked mental retardation. Here, Chen et al. show that Phf8 KO mouse have cognitive and synaptic plasticity impairment, and pharmacological inhibition of mTOR signaling can partially alleviate
Externí odkaz:
https://doaj.org/article/2ef75b4f01b048c09a3f547f5a48ff9a
Autor:
Natsuko Saito, Shunsuke Kimura, Tomomi Miyamoto, Sanae Fukushima, Misato Amagasa, Yoshinori Shimamoto, Chieko Nishioka, Shiki Okamoto, Chitoku Toda, Kohei Washio, Atsushi Asano, Ichiro Miyoshi, Eiki Takahashi, Hiroshi Kitamura
Publikováno v:
Biochemistry and Biophysics Reports, Vol 9, Iss C, Pp 322-329 (2017)
We previously reported that ubiquitin-specific protease (USP) 2 in macrophages down-regulates genes associated with metabolic diseases, suggesting a putative anti-diabetic role for USP2 in macrophages. In this study, we evaluate this role at both cel
Externí odkaz:
https://doaj.org/article/f2bf2c95144646929de023d6521dbddb