Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Eike Roscher"'
Publikováno v:
Mutagenesis. 5(4)
The metabolic pathways leading to genotoxicity of nitropropanes in mammalian cells were investigated by measuring the effects of 2-nitropropane (2-NP) and 1-nitropropane (1-NP) on various cell lines characterized for their expression of cytochrome P4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0afe123d72ecd6d38f721146d29aec
https://pubmed.ncbi.nlm.nih.gov/2398819
https://pubmed.ncbi.nlm.nih.gov/2398819
Publikováno v:
Nitroarenes ISBN: 9781461366942
We have assessed the cytotoxicity and genotoxicity of 1, 3-dinitropyrene (1, 3-DNP) and 1, 6-dinitropyrene (1, 6-DNP) in a panel of cell lines derived from various tissues of mouse, rat, hamster or man. The cell lines used were defined for their expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dad02d205e328dc8cea59e6b76de95da
https://doi.org/10.1007/978-1-4615-3800-4_35
https://doi.org/10.1007/978-1-4615-3800-4_35
Autor:
Friedrich J. Wiebel, Eike Roscher
Publikováno v:
Mutagenesis. 3:269-276
The present studies were aimed at evaluating the suitability of the differentiated Reuber hepatoma cells H4IIEC3/G- for monitoring permanent damage to the DNA caused by hepatotrophic chemicals. First we determined the profile of xenobiotic metabolizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d88ebb5ea94e564752fb2edbbf1f5d1
https://doi.org/10.1093/mutage/3.3.269
https://doi.org/10.1093/mutage/3.3.269
Autor:
Friedrich J. Wiebel, Eike Roscher
Publikováno v:
Mutagenesis. 4:292-296
Exposure of the differentiated rat hepatoma cells H4IIEC3 (H4) or several of their subclones to 20 mM N-nitrosodimethylamine (NDMA) did not significantly increase the number of 6-thioguanine (TG)-resistant cells or of micronuclei. Similar results wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0924c24035f1a56e2679bc411752d6a7
https://doi.org/10.1093/mutage/4.4.292
https://doi.org/10.1093/mutage/4.4.292
Autor:
Friedrich J., Wiebel, Eike, Roscher
Publikováno v:
ALTEX. 5(2)
Cells in continuous culture contain a large number of enzymes which are involved in the metabolism of potentially toxic chemicals. As a rule, the activities of these enzymes represent functions of low tussle specificity. In contrast, those functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f759cca0ebdcc4812cc8b5e57f25d17c
https://pubmed.ncbi.nlm.nih.gov/11227057
https://pubmed.ncbi.nlm.nih.gov/11227057